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Intra- and inter-observer variability in dependence of T1-time correction for common dynamic contrast enhanced MRI parameters in prostate cancer patients.

Abstract：

BACKGROUND:Dynamic contrast enhanced (DCE) MRI parameters are potential biomarkers to characterise tumour vasculature and distinguish it from the non-cancerous blood vessel system within the prostate. However, the inevitable presence of intra- and inter-observer variabilities is challenging in this context. Additionally, pre-contrast T1-time correction is a prerequisite to gain quantitative DCE parameters in the first place. The current study investigated the effect of individualized T1-time correction on intra- and inter-reader variability for quantitative DCE-parameters in prostatic lesions. METHODS:In this IRB-approved retrospective study, two experienced radiologists assessed DCE parameters using individually measured (A) and fixed (B) T1-times twice with a time difference of three weeks. The dataset consisted of 35 MRI-guided biopsy-proven prostate cancer lesions. Limits of agreement (LoA) and coefficients of variability (CoV) were calculated to assess intra- and inter-reader variabilities of the parameters. RESULTS:With exception of kep, for all DCE parameters both intra- and inter-reader CoV were smaller in B compared to A. Absolute kep values were largely insensitive to T1-time correction induced bias. The mean intra-reader CoVs [5%, 95% percentile] (over all four DCE parameters and both readers) were 6.7% [0.5%, 15.1%] in A and 3.9% [0.2%, 11.0%] in B. The inter-reader CoVs were 9.0% [0.6%, 25.8%] (A) and 7.0% [0.3%, 25.4%] (B). CONCLUSIONS:T1-time correction has a significant influence on the intra- and inter-reader variability. By applying individually measured T1-time correction, both intra- and inter-observer variability were found to increase. Out of all investigated DCE parameters, kep is the most robust to this investigated bias.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Daniel M,Polanec SH,Wengert G,Clauser P,Pinker K,Helbich TH,Georg D,Baltzer PAT

doi

10.1016/j.ejrad.2019.04.015

subject

Has Abstract

pub_date

2019-07-01 00:00:00

pages

27-33

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(19)30149-4

journal_volume

116

pub_type

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Intra- and inter-observer variability in dependence of T1-time correction for common dynamic contrast enhanced MRI parameters in prostate cancer patients.