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Preliminary European intravenous clinical experience with a new, low osmolar, nonionic contrast medium: ioversol (Optiray).

Abstract：

:The intravenous clinical trial program of ioversol (Optiray), a low osmolar, nonionic, monomeric contrast agent characterized by high hydrophilicity, is evaluated on the basis of results from the first clinical trials conducted in Europe as part of the development of the 300 and 350 mgI/ml formulations: 7 double-blind, comparative trials and 5 single trials were performed in a total of 743 patients, of whom 472 received ioversol and 271 a monomeric nonionic reference product. The diagnostic efficacy of ioversol was equivalent or superior to that of the reference products and tolerance was comparable to that of nonionic agents in terms of pain and heat sensations. No significant difference in adverse reactions was found and all the contrast agents studied were well tolerated by the patients.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Le Mignon MM,Azau C,Arthaud A,Bonnemain B

doi

10.1016/0720-048x(91)90094-c

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

126-33

issue

2

eissn

0720-048X

issn

1872-7727

pii

0720-048X(91)90094-C

journal_volume

13

pub_type

临床试验,杂志文章,随机对照试验

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