Abstract:
PURPOSE:Objective quantification of brain structure can aid diagnosis and therapeutic monitoring in several neuropsychiatric disorders. In this study, we aimed to compare direct and indirect quantification approaches for hippocampal formation changes in patients with mild cognitive impairment and Alzheimer's disease (AD). METHODS AND MATERIALS:Twenty-one healthy volunteers (mean age: 66.2), 21 patients with mild cognitive impairment (mean age: 66.6), and 10 patients with AD (mean age: 65.1) were enrolled. All subjects underwent extensive neuropsychological testing and were imaged at 1.5T (Vision, Siemens, Germany; T1w coronal TR=4 ms, Flip=13 degrees , FOV=250 mm, Matrix=256 x 256, 128 contiguous slices, 1.8mm). Direct measurement of the hippocampal formation was performed on coronal slices using a standardized protocol, while indirect temporal horn volume (THV) was calculated using a watershed algorithm-based software package (MeVis, Germany). Manual tracing took about 30 min, semi-automated measurement less than 3 min time. RESULTS:Successful direct and indirect quantification was performed in all subjects. A significant volume difference was found between controls and AD patients (p<0.001) with both the manual and the semi-automated approach. Group analysis showed a slight but not significant decrease of hippocampal volume and increase in temporal horn volume (THV) for subjects with mild cognitive impairment compared to volunteers (p<0.07). A significant correlation (p<0.001) of direct and indirect measurement was found. CONCLUSION:The presented indirect approach for hippocampus volumetry is equivalent to the direct approach and offers the advantages of observer independency, time reduction and thus usefulness for clinical routine.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Giesel FL,Thomann PA,Hahn HK,Politi M,Stieltjes B,Weber MA,Pantel J,Wilkinson ID,Griffiths PD,Schröder J,Essig Mdoi
10.1016/j.ejrad.2007.06.009subject
Has Abstractpub_date
2008-05-01 00:00:00pages
268-73issue
2eissn
0720-048Xissn
1872-7727pii
S0720-048X(07)00307-5journal_volume
66pub_type
杂志文章abstract::A survey of present opinions on the safety of diagnostic ultrasound applications is presented together with some data on output levels. Physical mechanisms involved in potential adverse effects are described. Labelling requirements of the equipment are defined and specified. These requirements are contained in a recen...
journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:
更新日期:1989-02-01 00:00:00
abstract::Diabetic mastopathy is a recently described collection of radiographical and histological features found in dense fibrous masses of the breast in long standing Type I diabetes. We describe the first case of bilateral disease with the alternate progression and regression of the disease over a 5 year period. A 45-year-o...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(97)00029-6
更新日期:1998-02-01 00:00:00
abstract:BACKGROUND:To investigate the diagnostic value of shear wave elastography (SWE) in identifying cervical small lymph node metastases in nasopharyngeal carcinoma (NPC) patients. MATERIALS AND METHODS:This prospective study was approved by the local institutional review board. From July 2014 to March 2016, 114 sLNs from ...
journal_title:European journal of radiology
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doi:10.1016/j.ejrad.2018.03.006
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abstract::The relative contrast enhancement of normal myometrium and small or medium size uterine fibroids and clinical stage I endometrial carcinomas were correlated to their microangiographically demonstrable vascularity. In four cases small uterine fibroids showed contrast enhancement equal to normal myometrium, independent ...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract::Radiation exposure from conventional fluoroscopy and from video disc recording was estimated during routine nailing of hip fractures. Mean fluoroscopic time with conventional fluoroscopy was 385 +/- 168 s. and with video disc recording 24 +/- 9 s. The time required for the X-ray system to form one television image, as...
journal_title:European journal of radiology
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更新日期:1981-05-01 00:00:00
abstract:PURPOSE:DCE MRI is a functional imaging modality, which is widely acknowledged to be linked to microvessel density in tissues. Therefore, it might be able to predict vessels in tumors. The present study sought to elucidate possible associations between microvessel density and histogram parameters in head and neck squam...
journal_title:European journal of radiology
pub_type: 杂志文章
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.02.036
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.ejrad.2016.10.006
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2011.01.108
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
doi:10.1016/S0720-048X(03)00173-6
更新日期:2004-03-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2014.07.009
更新日期:2014-10-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2016.11.025
更新日期:2017-01-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2019.108708
更新日期:2019-12-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/s0720-048x(01)00436-3
更新日期:2002-10-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1988-05-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2005.03.016
更新日期:2005-11-01 00:00:00
abstract::The relevance of sonography compared with conventional methods is demonstrated by means of 103 patients investigated with obstruction of the ureter. The knowledge of the exact topographic anatomy of the ureter in all sections enables the experienced investigator to demonstrate cause and position of ureteral obstructio...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:
更新日期:1987-02-01 00:00:00
abstract:PURPOSE:A new macromolecular MR contrast agent, Gd-DTPA-24-cascade-polymer, was assessed for MR angiography of peritumoral vessels in rats. MATERIAL AND METHODS:High resolution 3D-SPGR (TR/TE 100/5ms, alpha = 90 degrees) angiograms were acquired in 10 Fischer rats bearing subcutaneous R3230 mammary adenocarcinomas. MR...
journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(95)00645-7
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/0720-048x(90)90092-p
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journal_title:European journal of radiology
pub_type: 杂志文章
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doi:10.1016/j.ejrad.2013.06.008
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2012.11.023
更新日期:2013-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/s0720-048x(02)00332-7
更新日期:2003-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/j.ejrad.2017.05.006
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journal_title:European journal of radiology
pub_type: 杂志文章,随机对照试验
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2009.04.023
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journal_title:European journal of radiology
pub_type: 杂志文章
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journal_title:European journal of radiology
pub_type: 杂志文章,评审
doi:10.1016/s0720-048x(02)00019-0
更新日期:2002-04-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:10.1016/j.ejrad.2018.08.020
更新日期:2018-10-01 00:00:00
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journal_title:European journal of radiology
pub_type: 杂志文章
doi:
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