当前位置： SCI文献检索 > EUROPEAN JOURNAL OF RADIOLOGY期刊下所有文献 > Histogram analysis parameters derived from DCE-MRI in head and neck squamous cell cancer - Associations with microvessel density.

Histogram analysis parameters derived from DCE-MRI in head and neck squamous cell cancer - Associations with microvessel density.

Abstract：

PURPOSE:DCE MRI is a functional imaging modality, which is widely acknowledged to be linked to microvessel density in tissues. Therefore, it might be able to predict vessels in tumors. The present study sought to elucidate possible associations between microvessel density and histogram parameters in head and neck squamous cell carcinomas (HNSCC). METHOD:30 patients with histologically proven HNSCC were included in the study. DCE MRI was performed with a 3 T MRI and histogram analysis was calculated with a whole lesion measurement. In every case microvessel density was estimated with CD105 stained specimens. RESULTS:Median derived from Ktrans correlated with vessel area (ρ = 0.39, P = 0.034). No other Ktrans or Ve parameter reached statistically significance. Several Kep derived parameters correlated with vessel area as well as with vessel count. MinKep had the highest correlation coefficient with vessel area (ρ = 0.45, P = 0.01). ModeKep had the highest coefficient with vessel count (ρ = 0.41, P = 0.03). CONCLUSIONS:Histogram parameters derived from Kep might be used as surrogate imaging biomarkers for microvessel density parameters in HNSCC. MinimumKep showed the highest correlation with vessel area and Mode Kep with vessel count.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Meyer HJ,Hamerla G,Leifels L,Höhn AK,Surov A

doi

10.1016/j.ejrad.2019.108669

subject

Has Abstract

pub_date

2019-11-01 00:00:00

pages

108669

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(19)30319-5

journal_volume

120

pub_type

杂志文章

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