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F-18 FDG PET-CT in patients with recurrent glioma: comparison with contrast enhanced MRI.

Abstract：

PURPOSE:The purpose of the study was to compare the efficacies of FDG PET-CT and contrast enhanced MRI in detection of recurrent gliomas. METHODS:Ninety histopathologically proven glioma patients with clinical suspicion of recurrence were evaluated. All patients underwent FDG PET-CT scan and contrast enhanced MRI. Combination of clinical follow up, repeat imaging and biopsy (when available) was taken as gold standard. RESULTS:Based on gold standard criteria, 59 patients were positive and 31 patients were negative for recurrence. Overall sensitivity and specificity of FDG PET-CT were 70% and 97% respectively whereas that for contrast enhanced MRI was 95% and 23%. FDG PET-CT also has higher accuracy (80%) as compared to MRI (70%). FGD PET-CT has lower sensitivity than MRI in all grades, except for Grade II gliomas where their sensitivities are comparable (95% and 90%). Very low specificity of MRI was observed in all grades of tumour (18-33%). In contrast the specificity of FDG PET-CT was high across all grades (83-100%). CONCLUSION:FDG PET-CT is a highly specific modality for detecting recurrence in patients with gliomas and can effectively exclude post therapy changes.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Santra A,Kumar R,Sharma P,Bal C,Kumar A,Julka PK,Malhotra A

doi

10.1016/j.ejrad.2011.01.080

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

508-13

issue

3

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(11)00120-3

journal_volume

81

pub_type

杂志文章

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