Abstract:
PURPOSE:This study aimed at evaluating the computed tomography (CT) characteristics of resolving localized ground-glass opacities (GGOs) in a screening programme for lung cancer. MATERIAL AND METHODS:280 patients at high-risk for lung cancer (221 men, 59 women; mean age, 58.6 years), divided into four groups (lung cancer history (n = 83), head and neck cancer history (n = 63), symptomatic (n = 88) and asymptomatic (n = 46) cigarette smokers), were included in a prospective trial with annual low-dose CT for lung cancer screening. We retrospectively reviewed all localized GGOs, analyzed the CT characteristics on initial CT scans and changes during follow-up (median 29.1 months). Variables associated with resolution of GGOs were tested using chi-square or Mann-Whitney tests. RESULTS:A total of 75 GGOs were detected in 37 patients; 54.7% were present at baseline and 45.3% appeared on annual CT. During follow-up, 56.2% persisted and 43.8% disappeared. The resolving localized GGOs were significantly more often lobular GGOs (p = 0.006), polygonal in shape (p = 0.02), mixed (p = 0.003) and larger (p < 0.0001) than non-resolving localized GGOs. CONCLUSION:Localized GGOs are frequent and many disappeared on follow-up. CT characteristics of resolving GGOs show significant differences compared to persistent ones. This study emphasizes the importance of short-term CT follow-up in subjects with localized GGOs.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Felix L,Serra-Tosio G,Lantuejoul S,Timsit JF,Moro-Sibilot D,Brambilla C,Ferretti GRdoi
10.1016/j.ejrad.2009.09.008subject
Has Abstractpub_date
2011-03-01 00:00:00pages
410-6issue
3eissn
0720-048Xissn
1872-7727pii
S0720-048X(09)00527-0journal_volume
77pub_type
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journal_title:European journal of radiology
pub_type: 杂志文章
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journal_title:European journal of radiology
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journal_title:European journal of radiology
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章
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