Abstract：
INTRODUCTION:Computed tomography (CT) is a widespread and highly precise technique working in the energy range around 50-100 keV. For radiotherapy, however, the MeV energy range enables a better dose distribution. This gap between diagnosis and therapy can be overcome by the use of a modified CT machine in combination with heavy elements targeted to the tumour and used as photoelectric radiation enhancer. MATERIALS AND METHODS:The experimental setup consists of an X-ray optical module mounted at the exit of the X-ray tube of a clinical CT. The module converts the standard fan-shaped beam into a high intensity, monochromatized and focused beam. The radiation was characterized using an energy-dispersive detection system calibrated by synchrotron radiation and gel dosimetry. The photoelectric radiation enhancement for different elements was calculated and experimentally verified. RESULTS:The X-ray optical module filters selectively the energy of the tungsten K alpha-emission line (59.3 keV) with a full width at half maximum (FWHM) of 5 keV and focused the radiation onto a focal spot which coincides with the isocentre of the gantry. This results in a steep dose gradient at the centre of rotation qualified for locoregional radiation therapy. The photon energy of the quasi-monochromatic radiation agrees with the energy range of maximal photoelectric dose enhancement for gadolinium and iodine. CONCLUSION:An additional X-ray optical module optimized for targeted therapy and photoelectric dose enhancement allows the combination of diagnosis and radiotherapy on a clinical CT.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Jost G,Golfier S,Lawaczeck R,Weinmann HJ,Gerlach M,Cibik L,Krumrey M,Fratzscher D,Rabe J,Arkadiev V,Haschke M,Langhoff N,Wedell R,Luedemann L,Wust P,Pietsch Hdoi
10.1016/j.ejrad.2008.04.040subject
Has Abstractpub_date
2008-12-01 00:00:00pages
S63-8issue
3 Suppleissn
0720-048Xissn
1872-7727pii
S0720-048X(08)00281-7journal_volume
68pub_type
杂志文章abstract：OBJECTIVE:Our aim was to determine whether inward or outward movement of the secretions in the paranasal sinuses due to nose blowing after nasal decongestion has any effect on the paranasal sinus computed tomography (CT) images in patients with sinusitis and to asses whether nose blowing may result in misdiagnosis or o...
journal_title：European journal of radiology
pub_type： 杂志文章
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journal_title：European journal of radiology
pub_type： 杂志文章
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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journal_title：European journal of radiology
pub_type： 杂志文章,评审
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abstract：PURPOSE:To evaluate the feasibility and sensitivity of the 3D-reading of fecal-tagging CT colonography (CTC) with a novel structure-analysis electronic cleansing (SAEC) in detecting colorectal flat lesions in comparison with a cleansed 3D reading with Viatronix V3D Colon system (V3D) and primary uncleansed 2D reading (...
journal_title：European journal of radiology
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abstract：PURPOSE:The purpose of this retrospective study was to determine what gives rise to the periportal free air, and ligamentum teres and falciform ligament signs on CT in patients with gastrointestinal (GI) tract perforation, and whether these specific air distributions can play a clinically meaningful role in the diagnos...
journal_title：European journal of radiology
pub_type： 杂志文章
doi：10.1016/j.ejrad.2009.07.033
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journal_title：European journal of radiology
pub_type： 杂志文章
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journal_title：European journal of radiology
pub_type： 杂志文章,评审
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journal_title：European journal of radiology
pub_type： 杂志文章
doi：10.1016/j.ejrad.2009.11.003
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pub_type： 临床试验,杂志文章
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journal_title：European journal of radiology
pub_type： 评论,信件
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pub_type： 杂志文章,评审
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journal_title：European journal of radiology
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pub_type： 杂志文章,评审
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journal_title：European journal of radiology
pub_type： 杂志文章,评审
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journal_title：European journal of radiology
pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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journal_title：European journal of radiology
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pub_type： 杂志文章,随机对照试验
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journal_title：European journal of radiology
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journal_title：European journal of radiology
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