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Risk factors analysis of mirror aneurysms: A multi-center retrospective study based on clinical and demographic profile of patients.

Abstract：

:As a special subgroup of multiple intracranial aneurysms, mirror aneurysms are located bilaterally on the corresponding intracranial arteries. The current study sought to compare the clinical and demographic features of patients harboring mirror aneurysm, and to elucidate the corresponding risk factors. We performed a retrospective cohort study of 2641 intracranial aneurysms patients, who were admitted to our hospitals between January 2005 and June 2014. Patients were subdivided into three groups based on the inclusion criteria: (i) single (n=2250); (ii) non-mirror multiple (n=285); and (iii) mirror aneurysms (n=106). Clinical and demographic files of the three groups were collected and compared, and medical histories including stroke, hyperlipemia, hypertension, hyperglycemia, valvular heart disease were considered as potential risk factors. Potential morphological reasons for mirror cerebral aneurysms rupture, including aneurysms size, irregular walls and cerebral hemispheric dominance, were also compared. Our data showed that the male to female ratio of mirror aneurysms patients was 1:3.61, which was significantly different from that of single aneurysm (1:1.27) and multiple aneurysms (1:2.00). The prevalence of mirror aneurysms in women is higher than that in men (P<0.001). Older patients (especially 60-69 years old) also appear to be more vulnerable to mirror aneurysm than single aneurysm (P<0.001). In 84 mirror aneurysm patients the aneurysms were located on the internal carotid arteries (79.2%), most typically at the PComA or in the Cavernous ICA. Patients with medical history of hyperlipemia appear to have an increased risk of harboring mirror aneurysms. Larger aneurysm size and presence of an irregular aneurysm wall appear to be the morphological factors that predispose for mirror aneurysms rupture.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Huang ZQ,Zhou XW,Hou ZJ,Huang SQ,Meng ZH,Wang XL,Yu H,Feng LJ,Wang QJ,Li PA,Wen ZB

doi

10.1016/j.ejrad.2017.09.015

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

80-84

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(17)30373-X

journal_volume

pub_type

杂志文章,多中心研究

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Risk factors analysis of mirror aneurysms: A multi-center retrospective study based on clinical and demographic profile of patients.