当前位置： SCI文献检索 > EUROPEAN JOURNAL OF RADIOLOGY期刊下所有文献 > Improved correlation between CT emphysema quantification and pulmonary function test by density correction of volumetric CT data based on air and aortic density.

Improved correlation between CT emphysema quantification and pulmonary function test by density correction of volumetric CT data based on air and aortic density.

Abstract：

OBJECTIVES:To determine the improvement of emphysema quantification with density correction and to determine the optimal site to use for air density correction on volumetric computed tomography (CT). METHODS:Seventy-eight CT scans of COPD patients (GOLD II-IV, smoking history 39.2±25.3 pack-years) were obtained from several single-vendor 16-MDCT scanners. After density measurement of aorta, tracheal- and external air, volumetric CT density correction was conducted (two reference values: air, -1,000 HU/blood, +50 HU). Using in-house software, emphysema index (EI) and mean lung density (MLD) were calculated. Differences in air densities, MLD and EI prior to and after density correction were evaluated (paired t-test). Correlation between those parameters and FEV1 and FEV1/FVC were compared (age- and sex adjusted partial correlation analysis). RESULTS:Measured densities (HU) of tracheal- and external air differed significantly (-990 ± 14, -1016 ± 9, P<0.001). MLD and EI on original CT data, after density correction using tracheal- and external air also differed significantly (MLD: -874.9 ± 27.6 vs. -882.3 ± 24.9 vs. -860.5 ± 26.6; EI: 16.8 ± 13.4 vs. 21.1 ± 14.5 vs. 9.7 ± 10.5, respectively, P<0.001). The correlation coefficients between CT quantification indices and FEV1, and FEV1/FVC increased after density correction. The tracheal air correction showed better results than the external air correction. CONCLUSION:Density correction of volumetric CT data can improve correlations of emphysema quantification and PFT.

journal_name

Eur J Radiol

journal_title

European journal of radiology

authors

Kim SS,Seo JB,Kim N,Chae EJ,Lee YK,Oh YM,Lee SD

doi

10.1016/j.ejrad.2012.02.021

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

57-63

issue

1

eissn

0720-048X

issn

1872-7727

pii

S0720-048X(12)00156-8

journal_volume

83

pub_type

杂志文章

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