Abstract：
PURPOSE:To evaluate a strategy that used thermal-ablation of vertebral metastases (VM) to prevent vertebral related events (VRE) in patients with differentiated thyroid cancer (DTC). METHODS:This single center study retrospectively reviewed records and post-operative imaging of all DTC patients treated with thermal-ablation for asymptomatic VMs. Rate of local tumor control at first post-operative imaging, 12 and 24 months after thermal-ablation and rate of VREs at 12 and 24 months among the treated VMs were reported. New VMs that occurred during the follow-up and were not considered for additional thermal-ablation were moniroted and VREs were reported. RESULTS:Thermal-ablation was used to achieve local control of 41 VMs in 28 patients. Median post-treatment follow-up was 22 months [range: 12-80] and the mean delay for first post-operative imaging was 2 months [range: 0.6-7.5]. Local control at first post-operative imaging, 12 and 24 months was achieved in 87.8%, 82.9% and 75.6%, respectively. Among the treated VMs the rates of VRE was 7.3% at 2 years, significantly lower if local control was achieved at first post-operative imaging than if it was not (0% vs 30%, p = 0.011, OR = 0.184 [95%CI = 0.094-0.360]). After thermal-ablation procedures, 19 news VMs occurred in 11 patients (39.2%) with a median interval of 8 months [range 1-26] and remained untreated. Among these untreated VMs, the rate of VREs at 2 years was significantly higher compared to the treated VMs: (36.8% vs. 7.3%, p = 0.008, OR = 0.135, [95%CI = 0.030-0.607]). CONCLUSION:local tumor control of VMs using thermal-ablation decreases the risk of VREs in DTC patients.
journal_name
Eur J Radioljournal_title
European journal of radiologyauthors
Barat M,Tselikas L,de Baère T,Gravel G,Yevich S,Delpla A,Magand N,Louvel G,Hadoux J,Berdelou A,Terroir M,Baudin E,Schlumberger M,Leboulleux S,Deschamps Fdoi
10.1016/j.ejrad.2019.108650subject
Has Abstractpub_date
2019-10-01 00:00:00pages
108650eissn
0720-048Xissn
1872-7727pii
S0720-048X(19)30300-6journal_volume
119pub_type
杂志文章abstract：:The purpose of this study is to clarify the prevalence, spectrum of associated tumors and the diagnostic value of the linear meningeal thickening and enhancement adjacent to a peripherally located cranial mass "dural tail sign"(DTS) in contrast enhanced magnetic resonance imaging (MRI). In this prospective descriptive...
journal_title：European journal of radiology
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journal_title：European journal of radiology
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pub_type： 杂志文章,评审
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