Abstract：
:For several years it has been debated whether the Ca-pump in smooth muscle is located in the plasma membrane or in the endoplasmic reticulum (alias sarcoplasmic reticulum). Experimental evidence using skinned smooth muscle cells and subcellular membrane fractions isolated from a number of smooth muscles is reviewed here to hopefully resolve this issue. The inescapable conclusion is that there are two modes of nonmitochondrial ATP-dependent Ca-transport. The first one, unaffected by oxalate, is localized in the plasma membranes and the second, potentiated by oxalate, is localized in the endoplasmic reticulum. Clear experiments to delineate the roles of the two pumps in the excitation-contraction cycle of the smooth muscle remain to be conducted.
journal_name
Cell Calciumjournal_title
Cell calciumauthors
Grover AKdoi
10.1016/0143-4160(85)90008-9subject
Has Abstractpub_date
1985-06-01 00:00:00pages
227-36issue
3eissn
0143-4160issn
1532-1991pii
0143-4160(85)90008-9journal_volume
6pub_type
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