当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.

Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation.

Abstract：

:IL-27-induced type 1 regulatory T (Tr1) cells suppress autoimmunity by producing IL-10. Signal transducer and activator of transcription (STAT) 1 and STAT3 have been described as key transcription factors that promote IL-10 secretion from Tr1 cells induced by IL-27. However, the molecular pathways for negatively regulating Tr1 cell differentiation remain elusive. Here, we show that IL-27 induces metallothioneins (MTs) that in turn prevent Tr1 cell development. MT expression leads to the reduction of STAT1 and STAT3 phosphorylation under Tr1 differentiation condition, resulting in impaired IL-10 production. Accordingly, Tr1 cells derived from MT-deficient mice showed an increased ability to produce IL-10 and potently suppress experimental autoimmune encephalomyelitis upon adoptive transfer. Moreover, activation of STAT1 and/or STAT3 can overcome the suppression of IL-10 by MTs, indicating a dynamic balance between STATs and MTs in regulating IL-10 during Tr1 cell differentiation.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Wu C,Pot C,Apetoh L,Thalhamer T,Zhu B,Murugaiyan G,Xiao S,Lee Y,Rangachari M,Yosef N,Kuchroo VK

doi

10.1073/pnas.1211776110

subject

Has Abstract

pub_date

2013-05-07 00:00:00

pages

7802-7

issue

19

eissn

0027-8424

issn

1091-6490

pii

1211776110

journal_volume

110

pub_type

杂志文章

相关文献

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA文献大全
  • Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: suggestion that the J segments are involved in the structural correlate of the idiotype.

    abstract：:The complete amino acid sequences of the variable regions of two human IgM anti-gamma globulins are reported. The two proteins, Sie and Wol, share idiotypic determinants that are distinct from those shared by the two previously sequenced IgM anti-gamma globulins, Lay and Pom [Capra, J. D. & Kehoe, J. M. (1974) Proc. N...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.78.6.3799

    authors： Andrews DW,Capra JD

    更新日期：1981-06-01 00:00:00

  • Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig.

    abstract：:Intracellular recordings were obtained from vagal neurons and their response to oxytocin was investigated in slices from the rat and the guinea pig brainstem. After recording, Lucifer yellow was injected into the cells to verify their localization within the dorsal motor nucleus of the vagus nerve (dmnX). In the rat, ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.84.11.3926

    authors： Raggenbass M,Dubois-Dauphin M,Charpak S,Dreifuss JJ

    更新日期：1987-06-01 00:00:00

  • A common allosteric site and mechanism in caspases.

    abstract：:We present a common allosteric mechanism for control of inflammatory and apoptotic caspases. Highly specific thiol-containing inhibitors of the human inflammatory caspase-1 were identified by using disulfide trapping, a method for site-directed small-molecule discovery. These compounds became trapped by forming a disu...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0602571103

    authors： Scheer JM,Romanowski MJ,Wells JA

    更新日期：2006-05-16 00:00:00

  • Phase locking between human primary and secondary somatosensory cortices.

    abstract：:Unilateral stimulation of human peripheral nerves activates the primary somatosensory cortex (SI) contralaterally and the secondary somatosensory cortex (SII) bilaterally. We aimed at characterizing phase locking between SI and SII in response to electric stimuli applied once every 3 s to the right median nerve at the...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0437944100

    authors： Simões C,Jensen O,Parkkonen L,Hari R

    更新日期：2003-03-04 00:00:00

  • The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4.

    abstract：:Chemokines play a key role in inflammation. They are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types, including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. Here, we investigated a possible neuroendocrine role of the ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0602620103

    authors： Callewaere C,Banisadr G,Desarménien MG,Mechighel P,Kitabgi P,Rostène WH,Mélik Parsadaniantz S

    更新日期：2006-05-23 00:00:00

  • A catalytic antibody against cocaine prevents cocaine's reinforcing and toxic effects in rats.

    abstract：:Cocaine addiction and overdose have long defied specific treatment. To provide a new approach, the high-activity catalytic antibody mAb 15A10 was elicited using a transition-state analog for the hydrolysis of cocaine to nontoxic, nonaddictive products. In a model of cocaine overdose, mAb 15A10 protected rats from coca...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.95.17.10176

    authors： Mets B,Winger G,Cabrera C,Seo S,Jamdar S,Yang G,Zhao K,Briscoe RJ,Almonte R,Woods JH,Landry DW

    更新日期：1998-08-18 00:00:00

  • WNT/RYK signaling restricts goblet cell differentiation during lung development and repair.

    abstract：:Goblet cell metaplasia and mucus hypersecretion are observed in many pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. However, the regulation of goblet cell differentiation remains unclear. Here, we identify a regulator of this process in an N-ethyl-N-nitrosourea...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1911071116

    authors： Kim HT,Yin W,Nakamichi Y,Panza P,Grohmann B,Buettner C,Guenther S,Ruppert C,Kobayashi Y,Guenther A,Stainier DYR

    更新日期：2019-12-17 00:00:00

  • Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly.

    abstract：:The 26S proteasome, a molecular machine responsible for regulated protein degradation, consists of a proteolytic core particle (20S CP) associated with 19S regulatory particles (19S RPs) subdivided into base and lid subcomplexes. The assembly of 19S RP base subcomplex is mediated by multiple dedicated chaperones. Amon...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1116538109

    authors： Barrault MB,Richet N,Godard C,Murciano B,Le Tallec B,Rousseau E,Legrand P,Charbonnier JB,Le Du MH,Guérois R,Ochsenbein F,Peyroche A

    更新日期：2012-04-24 00:00:00

  • Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells.

    abstract：:Stem cells have been identified as essential for maintaining multiple organ systems, including the hematopoietic system. The distinct cell fates of self-renewal and differentiation of hematopoietic stem cells (HSCs) depend on cell division. Recently, several negative regulators of the cell cycle, such as the cyclin-de...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0603389103

    authors： Walkley CR,Orkin SH

    更新日期：2006-06-13 00:00:00

  • Diversity of Holocene life forms in fossil glacier ice.

    abstract：:Studies of biotic remains of polar ice caps have been limited to morphological identification of plant pollen and spores. By using sensitive molecular techniques, we now demonstrate a much greater range of detectable organisms; from 2000- and 4000-year-old ice-core samples, we obtained and characterized 120 clones tha...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.14.8017

    authors： Willerslev E,Hansen AJ,Christensen B,Steffensen JP,Arctander P

    更新日期：1999-07-06 00:00:00

  • Kinetic diversity of amyloid oligomers.

    abstract：:The spontaneous assembly of proteins into amyloid fibrils is a phenomenon central to many increasingly common and currently incurable human disorders, including Alzheimer's and Parkinson's diseases. Oligomeric species form transiently during this process and not only act as essential intermediates in the assembly of n...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1922267117

    authors： Dear AJ,Michaels TCT,Meisl G,Klenerman D,Wu S,Perrett S,Linse S,Dobson CM,Knowles TPJ

    更新日期：2020-06-02 00:00:00

  • Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.

    abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.14.8247

    authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

    更新日期：1999-07-06 00:00:00

  • Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease.

    abstract：:We have identified a murine gene, metaxin, that spans the 6-kb interval separating the glucocerebrosidase gene (GC) from the thrombospondin 3 gene on chromosome 3E3-F1. Metaxin and GC are transcribed convergently; their major polyadenylylation sites are only 431 bp apart. On the other hand, metaxin and the thrombospon...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.92.10.4547

    authors： Bornstein P,McKinney CE,LaMarca ME,Winfield S,Shingu T,Devarayalu S,Vos HL,Ginns EI

    更新日期：1995-05-09 00:00:00

  • Changing resonator geometry to boost sound power decouples size and song frequency in a small insect.

    abstract：:Despite their small size, some insects, such as crickets, can produce high amplitude mating songs by rubbing their wings together. By exploiting structural resonance for sound radiation, crickets broadcast species-specific songs at a sharply tuned frequency. Such songs enhance the range of signal transmission, contain...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1200192109

    authors： Mhatre N,Montealegre-Z F,Balakrishnan R,Robert D

    更新日期：2012-05-29 00:00:00

  • The 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY NMR experiment with diagonal peak suppression.

    abstract：:In our 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY experiment, the TROSY principle (transverse relaxation-optimized spectroscopy) is used in three-dimensional (3D) (15)N-resolved nuclear Overhauser enhancement spectroscopy (NOESY), which enables resonance assignments by sequential nuclear Overhauser effects and the collection...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.96.17.9607

    authors： Pervushin KV,Wider G,Riek R,Wüthrich K

    更新日期：1999-08-17 00:00:00

  • Efficient replacement of plasma membrane outer leaflet phospholipids and sphingolipids in cells with exogenous lipids.

    abstract：:Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid exchange can be used to maximally...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1610705113

    authors： Li G,Kim J,Huang Z,St Clair JR,Brown DA,London E

    更新日期：2016-12-06 00:00:00

  • Entpd5 is essential for skeletal mineralization and regulates phosphate homeostasis in zebrafish.

    abstract：:Bone mineralization is an essential step during the embryonic development of vertebrates, and bone serves vital functions in human physiology. To systematically identify unique gene functions essential for osteogenesis, we performed a forward genetic screen in zebrafish and isolated a mutant, no bone (nob), that does ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1214231110

    authors： Huitema LF,Apschner A,Logister I,Spoorendonk KM,Bussmann J,Hammond CL,Schulte-Merker S

    更新日期：2012-12-26 00:00:00

  • Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans.

    abstract：:Fungi produce numerous low molecular weight molecules endowed with a multitude of biological activities. However, mining the full-genome sequences of fungi indicates that their potential to produce secondary metabolites is greatly underestimated. Because most of the biosynthesis gene clusters are silent under laborato...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0901870106

    authors： Schroeckh V,Scherlach K,Nützmann HW,Shelest E,Schmidt-Heck W,Schuemann J,Martin K,Hertweck C,Brakhage AA

    更新日期：2009-08-25 00:00:00

  • Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes.

    abstract：:Carbohydrate-based vaccines have shown therapeutic efficacy for infectious disease and cancer. The mushroom Ganoderma lucidum (Reishi) containing complex polysaccharides has been used as antitumor supplement, but the mechanism of immune response has rarely been studied. Here, we show that the mice immunized with a l-f...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1312457110

    authors： Liao SF,Liang CH,Ho MY,Hsu TL,Tsai TI,Hsieh YS,Tsai CM,Li ST,Cheng YY,Tsao SM,Lin TY,Lin ZY,Yang WB,Ren CT,Lin KI,Khoo KH,Lin CH,Hsu HY,Wu CY,Wong CH

    更新日期：2013-08-20 00:00:00

  • A single-stranded DNA-binding protein from Crithidia fasciculata recognizes the nucleotide sequence at the origin of replication of kinetoplast DNA minicircles.

    abstract：:A sequence-specific single-stranded DNA-binding protein from the trypanosomatid protozoan Crithidia fasciculata binds to a sequence of 12 nucleotides located at the origin of replication of kinetoplast DNA minicircles. This sequence, termed the universal minicircle sequence (UMS), is conserved in the kinetoplast DNA m...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.89.15.6891

    authors： Tzfati Y,Abeliovich H,Kapeller I,Shlomai J

    更新日期：1992-08-01 00:00:00

  • Adaptive integration of habits into depth-limited planning defines a habitual-goal-directed spectrum.

    abstract：:Behavioral and neural evidence reveal a prospective goal-directed decision process that relies on mental simulation of the environment, and a retrospective habitual process that caches returns previously garnered from available choices. Artificial systems combine the two by simulating the environment up to some depth ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1609094113

    authors： Keramati M,Smittenaar P,Dolan RJ,Dayan P

    更新日期：2016-11-08 00:00:00

  • A genome-wide analysis of CpG dinucleotides in the human genome distinguishes two distinct classes of promoters.

    abstract：:A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs) interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the dinucleotide. CGIs are generally associated with promoters; genes, whose promoters are especially rich in CpG sequences, tend to be expressed in m...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0510310103

    authors： Saxonov S,Berg P,Brutlag DL

    更新日期：2006-01-31 00:00:00

  • A brain-specific SGK1 splice isoform regulates expression of ASIC1 in neurons.

    abstract：:Neurodegenerative diseases and noxious stimuli to the brain enhance transcription of serum- and glucocorticoid-induced kinase-1 (SGK1). Here, we report that the SGK1 gene encodes a brain-specific additional isoform, SGK1.1, which exhibits distinct regulation, properties, and functional effects. SGK1.1 decreases expres...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0800958105

    authors： Arteaga MF,Coric T,Straub C,Canessa CM

    更新日期：2008-03-18 00:00:00

  • Inhibition of hormone-sensitive adenyl cyclase by phenothiazines.

    abstract：:Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyr...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.65.2.454

    authors： Wolff J,Jones AB

    更新日期：1970-02-01 00:00:00

  • Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes.

    abstract：:Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.1313185110

    authors： Liu T,Laidlaw TM,Katz HR,Boyce JA

    更新日期：2013-10-15 00:00:00

  • In vivo modulation of morphogenetic movements in Drosophila embryos with femtosecond laser pulses.

    abstract：:The complex biomechanical events associated with embryo development are investigated in vivo, by using femtosecond laser pulse-induced ablation combined with multimodal nonlinear microscopy. We demonstrate controlled intravital ablations preserving local cytoskeleton dynamics and resulting in the modulation of specifi...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0405316102

    authors： Supatto W,Débarre D,Moulia B,Brouzés E,Martin JL,Farge E,Beaurepaire E

    更新日期：2005-01-25 00:00:00

  • Collection, focusing, and metering of DNA in microchannels using addressable electrode arrays for portable low-power bioanalysis.

    abstract：:Although advances in microfluidic technology have enabled increasingly sophisticated biosensing and bioassay operations to be performed at the microscale, many of these applications employ such small amounts of charged biomolecules (DNA, proteins, and peptides) that they must first be preconcentrated to a detectable l...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.0506848103

    authors： Shaikh FA,Ugaz VM

    更新日期：2006-03-28 00:00:00

  • Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy.

    abstract：:We have identified a subset of CD56(+)CD3(-) human natural killer (NK) cells that express CD4 and the HIV coreceptors CCR5 and CXCR4. These cells can be productively infected in vitro by both CCR5- and CXCR4-using molecular clones of HIV-1 in a CD4-dependent manner. Analysis of HIV-infected persons showed that viral D...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.102672999

    authors： Valentin A,Rosati M,Patenaude DJ,Hatzakis A,Kostrikis LG,Lazanas M,Wyvill KM,Yarchoan R,Pavlakis GN

    更新日期：2002-05-14 00:00:00

  • Large electrical currents traverse developing Ceropia follicles.

    abstract：:An intense (up to 20 muA/cm(2)) steady electrical current enters the anterior or nurse cell end of the growing follicle (or oocyte-nurse cell complex) of the Cecropia moth and is balanced by a more diffuse current leaving elsewhere. In late growth stages, the total transfollicular current is about 100 nA. Moreover, a ...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.76.3.1328

    authors： Jaffe LF,Woodruff RI

    更新日期：1979-03-01 00:00:00

  • External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.

    abstract：:The present work shows that arachidonic acid and some other long chain polyunsaturated fatty acids such as docosahexaenoic acid, which is abundant in fish oil, produce a direct open channel block of the major voltage-dependent K+ channel (Kv1.5) cloned in cardiac cells. The inhibitory action of these selected fatty ac...

    journal_title：Proceedings of the National Academy of Sciences of the United States of America

    pub_type： 杂志文章

    doi：10.1073/pnas.91.5.1937

    authors： Honoré E,Barhanin J,Attali B,Lesage F,Lazdunski M

    更新日期：1994-03-01 00:00:00