Neurons in the dorsal motor nucleus of the vagus nerve are excited by oxytocin in the rat but not in the guinea pig.

abstract：:Adenovirus (Ad) vectors have been extensively used to deliver recombinant genes to a great variety of cell types in vitro and in vivo. Ad-based vectors are available that replace the Ad early region 1 (E1) with recombinant foreign genes. The resultant E1-deleted vectors can then be propagated on 293 cells, a human emb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amalfitano A,Begy CR,Chamberlain JS

更新日期：1996-04-16 00:00:00

abstract：:Significantly above-chance detection of stimuli presented within the field defect of patients with postgeniculate lesions is termed "blindsight." It has been proposed that those with blindsight are more likely to benefit from visual rehabilitation by repeated stimulation, leading to increased visual sensitivity within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahraie A,Trevethan CT,MacLeod MJ,Urquhart J,Weiskrantz L

更新日期：2013-11-05 00:00:00

abstract：:The lamB protein, the receptor for phage lambda, was purified from the outer membrane of Escherichia coli K-12 by extraction with Triton X-100 and EDTA, chromatography on DEAE-Sephacel in Triton X-100, exchange of Triton for cholate by gel filtration, and chromatography on Sephacryl S-200 in cholate, NaCl, and EDTA. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luckey M,Nikaido H

更新日期：1980-01-01 00:00:00

abstract：:Understanding the mechanisms of Salmonella virulence is an important challenge. The capacity of this intracellular bacterial pathogen to cause diseases depends on the expression of virulence factors including the second type III secretion system (TTSS-2), which is used to translocate into the eukaryotic cytosol a set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henry T,Couillault C,Rockenfeller P,Boucrot E,Dumont A,Schroeder N,Hermant A,Knodler LA,Lecine P,Steele-Mortimer O,Borg JP,Gorvel JP,Méresse S

更新日期：2006-09-05 00:00:00

abstract：:Adenosine 3':5'-cyclic monophosphate (cAMP) and guanosine 3':5'-cyclic monophosphate (cGMP) were localized in cells of rat kidney cortex by an immunocytochemical technique before and after perfusion with parathyroid hormone (PTH). In control tissues the cAMP antiserum detected approximately the same intensity of fluor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dousa TP,Barnes LD,Ong SH,Steiner AL

更新日期：1977-08-01 00:00:00

abstract：:The expression of interleukin 2 receptors (IL-2R) is a critical step leading to normal lymphocyte proliferation. Since thymosin fraction 5 (TF5), a thymic hormone preparation, enhances lymphoproliferative responses of human cells, we examined the effects of TF5 on the expression of IL-2R on mitogen-stimulated human ly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sztein MB,Serrate SA,Goldstein AL

更新日期：1986-08-01 00:00:00

abstract：:Decision-making accuracy typically increases through collective integration of people's judgments into group decisions, a phenomenon known as the wisdom of crowds. For simple perceptual laboratory tasks, classic signal detection theory specifies the upper limit for collective integration benefits obtained by weighted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juni MZ,Eckstein MP

更新日期：2017-05-23 00:00:00

abstract：:Column chromatography on (dT)(12-18)-cellulose was used to detect and isolate a novel DNA polymerase activity from human breast tumor cell line HBT-3. The new enzyme is similar to those of mammalian RNA tumor viruses in its molecular size, preference for poly(A).(dT)(12-18) as compared to either poly(dA).(dT)(12-18) o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerwin BI,Bassin RH

更新日期：1973-08-01 00:00:00

abstract：:Surface Ig (sIg) of follicular lymphoma (FL) is vital for tumor cell survival. We found previously that the Ig in FL is unusual, because the variable region genes carry sequence motifs for N-glycan addition. These are introduced by somatic mutation and are tumor specific. Unexpectedly, added glycans terminate at high ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coelho V,Krysov S,Ghaemmaghami AM,Emara M,Potter KN,Johnson P,Packham G,Martinez-Pomares L,Stevenson FK

更新日期：2010-10-26 00:00:00

abstract：:In epithelia, a primary damage of tight junctions (TJ) always leads to a secondary disruption of adherens junction (AJ), and vice versa. This response, if occurring in the testis, would disrupt spermatogenesis because the blood-testis barrier (BTB) must remain intact during the transit of spermatids in the seminiferou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lie PP,Chan AY,Mruk DD,Lee WM,Cheng CY

更新日期：2010-06-22 00:00:00

abstract：:Oncogenic mutations in the small GTPase KRAS are frequently found in human cancers, and, currently, there are no effective targeted therapies for these tumors. Using a combinatorial siRNA approach, we analyzed a panel of KRAS mutant colorectal and pancreatic cancer cell lines for their dependency on 28 gene nodes that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee CS,Lee LC,Yuan TL,Chakka S,Fellmann C,Lowe SW,Caplen NJ,McCormick F,Luo J

更新日期：2019-03-05 00:00:00

abstract：:Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of changes in the highly heterogeneous mixtures of lipids found in eukaryotic cells is central to understanding the complex functions in which lipids participate. P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova PT,Cerda BA,Horn DM,Cohen JS,McLafferty FW,Brown HA

更新日期：2001-06-19 00:00:00

abstract：:Nucleotide excision repair proteins have been implicated in genetic recombination by experiments in Saccharomyces cerevisiae and Drosophila melanogaster, but their role, if any, in mammalian cells is undefined. To investigate the role of the nucleotide excision repair gene ERCC1, the hamster homologue to the S. cerevi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sargent RG,Rolig RL,Kilburn AE,Adair GM,Wilson JH,Nairn RS

更新日期：1997-11-25 00:00:00

abstract：:Little is known about how genetic variation and epigenetic marks interact to shape differences in behavior. The foraging (for) gene regulates behavioral differences between the rover and sitter Drosophila melanogaster strains, but the molecular mechanisms through which it does so have remained elusive. We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anreiter I,Kramer JM,Sokolowski MB

更新日期：2017-11-21 00:00:00

abstract：:The ubiquitous gasotransmitter hydrogen sulfide (H2S) has been recognized to play a crucial role in human health. Using cystathionine γ-lyase (CSE)-deficient mice, we demonstrate an unexpected role of H2S in Mycobacterium tuberculosis (Mtb) pathogenesis. We showed that Mtb-infected CSE-/- mice survive longer than WT m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahman MA,Cumming BM,Addicott KW,Pacl HT,Russell SL,Nargan K,Naidoo T,Ramdial PK,Adamson JH,Wang R,Steyn AJC

更新日期：2020-03-24 00:00:00

abstract：:E12 and E47 are two non-tissue-specific helix-loop-helix (HLH) transcription factors encoded by the E2A gene. Previous studies suggested that they are involved in regulation of differentiation in many tissue types including muscle, blood, and nerve through direct heterodimer interactions with tissue-specific HLH prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhuang Y,Kim CG,Bartelmez S,Cheng P,Groudine M,Weintraub H

更新日期：1992-12-15 00:00:00

abstract：:Most transmissible spongiform encephalopathies arise either spontaneously or by infection. Mutations of PRNP, which encodes the prion protein, PrP, segregate with phenotypically similar diseases. Here we report that moderate overexpression in transgenic mice of mPrP(170N,174T), a mouse PrP with two point mutations tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sigurdson CJ,Nilsson KP,Hornemann S,Heikenwalder M,Manco G,Schwarz P,Ott D,Rülicke T,Liberski PP,Julius C,Falsig J,Stitz L,Wüthrich K,Aguzzi A

更新日期：2009-01-06 00:00:00

abstract：:We have isolated lentivirus strains that are related to the human immunodeficiency virus (HIV) from African green monkeys (Cercopithecus aethiops; AGM). Although immunologically related, these SIVagm are clearly distinct from other simian immunodeficiency virus (SIV) isolates, including isolates from Macaca mulatta (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus G,Werner A,Baier M,Binniger D,Ferdinand FJ,Norley S,Kurth R

更新日期：1989-04-01 00:00:00

abstract：:Exposure of adipocytes to antibodies to the insulin receptor results in a blockade of (125)I-labeled insulin binding, stimulation of glucose oxidation, and many more insulin-like effects. Allowing for differences in purity, antireceptor antibody is equipotent with insulin on a molar basis. Both the bivalent F(ab')(2) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn CR,Baird KL,Jarrett DB,Flier JS

更新日期：1978-09-01 00:00:00

abstract：:Recent archaeological discoveries have revealed that pigment use, beads, engravings, and sophisticated stone and bone tools were already present in southern Africa 75,000 y ago. Many of these artifacts disappeared by 60,000 y ago, suggesting that modern behavior appeared in the past and was subsequently lost before be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： d'Errico F,Backwell L,Villa P,Degano I,Lucejko JJ,Bamford MK,Higham TF,Colombini MP,Beaumont PB

更新日期：2012-08-14 00:00:00

abstract：:How can collective action evolve when individuals benefit from cooperation regardless of whether they pay its participation costs? According to one influential perspective, collective action problems are common, especially when groups are large, but may be solved when individuals who have more to gain from the collect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Langergraber KE,Watts DP,Vigilant L,Mitani JC

更新日期：2017-07-11 00:00:00

abstract：:In most human follicular B cell lymphomas the bcl-2 gene is up-regulated as a result of the t(14;18) chromosomal translocation generating a hybrid bcl-2-IgH mRNA. Recently, we have identified in t(14;18)-positive cells a bcl-2-IgH mRNA in the antisense orientation, putatively responsible for the overexpression of bcl-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morelli S,Delia D,Capaccioli S,Quattrone A,Schiavone N,Bevilacqua A,Tomasini S,Nicolin A

更新日期：1997-07-22 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:The use of molecular methods is altering our understanding of the microbial biosphere and the complexity of the tree of life. Here, we report a newly discovered uncultured plastid-bearing eukaryotic lineage named the rappemonads. Phylogenies using near-complete plastid ribosomal DNA (rDNA) operons demonstrate that thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim E,Harrison JW,Sudek S,Jones MD,Wilcox HM,Richards TA,Worden AZ,Archibald JM

更新日期：2011-01-25 00:00:00

abstract：:The paradigmatic example of a continuous quantum phase transition is the transverse field Ising ferromagnet. In contrast to classical critical systems, whose properties depend only on symmetry and the dimension of space, the nature of a quantum phase transition also depends on the dynamics. In the transverse field Isi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maharaj AV,Rosenberg EW,Hristov AT,Berg E,Fernandes RM,Fisher IR,Kivelson SA

更新日期：2017-12-19 00:00:00

abstract：:The ras oncogene products require membrane localization for their function, and this is thought to be accomplished by the addition of a palmitoyl group to a cysteine residue near the carboxyl terminus of the nascent chain. A lipidated carboxyl-terminal cysteine residue is also found in sequence-related yeast sex facto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clarke S,Vogel JP,Deschenes RJ,Stock J

更新日期：1988-07-01 00:00:00

abstract：:One of the most basic predictions of almost any model of crime is that individual time preferences matter. However, empirical evidence on this fundamental property is essentially nonexistent. To our knowledge, this paper provides the first pieces of evidence on the link between time discounting and crime. We use a uni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Åkerlund D,Golsteyn BH,Grönqvist H,Lindahl L

更新日期：2016-05-31 00:00:00

abstract：:Object recognition is challenging because the same object can produce vastly different images, mixing signals related to its identity with signals due to its image attributes, such as size, position, rotation, etc. Previous studies have shown that both signals are present in high-level visual areas, but precisely how ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratan Murty NA,Arun SP

更新日期：2018-04-03 00:00:00

abstract：:The molecular basis for the absence of anthocyanins and proanthocyanidins in four independent sodium azide-induced ant18 mutants of barley was examined by sequencing the gene encoding dihydroflavonol 4-reductase in these mutants. Sodium azide generated 21 base substitutions, which corresponds to 0.17% of the 12,704 nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olsen O,Wang X,von Wettstein D

更新日期：1993-09-01 00:00:00

abstract：:Exposure of murine hepatoma (Hepa 1c1c7) cells to a variety of chemical agents known to protect animals against the neoplastic, mutagenic, and other toxic effects of chemical carcinogens results in dose- and time-dependent inductions of NAD(P)H:quinone reductase (EC 1.6.99.2). This enzyme protects against quinone toxi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Long MJ,Prochaska HJ,Talalay P

更新日期：1986-02-01 00:00:00