Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy.

abstract：:Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Sun JP,Zhou B,Zhang ZY

更新日期：2006-04-04 00:00:00

abstract：:The anti-Tac monoclonal antibody is known to bind to the p55 chain of the human interleukin 2 receptor and to inhibit proliferation of T cells by blocking interleukin 2 binding. However, use of anti-Tac as an immunosuppressant drug would be impaired by the human immune response against this murine antibody. We have th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Queen C,Schneider WP,Selick HE,Payne PW,Landolfi NF,Duncan JF,Avdalovic NM,Levitt M,Junghans RP,Waldmann TA

更新日期：1989-12-01 00:00:00

abstract：:An artificial increase of cyclic diguanylate (c-di-GMP) levels in Sinorhizobium meliloti 8530, a bacterium that does not carry known cellulose synthesis genes, leads to overproduction of a substance that binds the dyes Congo red and calcofluor. Sugar composition and methylation analyses and NMR studies identified this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pérez-Mendoza D,Rodríguez-Carvajal MÁ,Romero-Jiménez L,Farias Gde A,Lloret J,Gallegos MT,Sanjuán J

更新日期：2015-02-17 00:00:00

abstract：:Certain models of spoken-language processing, like those for many other perceptual and cognitive processes, posit continuous uptake of sensory input and dynamic competition between simultaneously active representations. Here, we provide compelling evidence for this continuity assumption by using a continuous response,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spivey MJ,Grosjean M,Knoblich G

更新日期：2005-07-19 00:00:00

abstract：:The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a monoclonal antibody (mAb) and, to a lesser extent, OKT4 mAb to the CD4 cell receptor for human immunodeficiency virus type 1 (HIV-1). The effect was seen within 1 min at an ATA concentration ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schols D,Baba M,Pauwels R,Desmyter J,De Clercq E

更新日期：1989-05-01 00:00:00

abstract：:The sequences of large insert clones containing genomic DNA that is orthologous to the maize adh1 region were obtained for sorghum, rice, and the adh1-homoeologous region of maize, a remnant of the tetraploid history of the Zea lineage. By using all four genomes, it was possible to describe the nature, timing, and lin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ilic K,SanMiguel PJ,Bennetzen JL

更新日期：2003-10-14 00:00:00

abstract：:Positive lower bounds for pseudo-differential operators with nonnegative symbols are derived; the bounds in particular yield subelliptic estimates for operators arising as sums of squares of vector fields. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fefferman C,Phong DH

更新日期：1979-12-01 00:00:00

abstract：:To identify genes important for hair-cell function, we conducted a mutagenic screen in zebrafish. Larvae from one mutant line, ru848, were unresponsive to acoustic stimuli and unable to balance. The mutation results in a 90% reduction in hair-cell number and partial retinal degeneration by 5 days postfertilization. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starr CJ,Kappler JA,Chan DK,Kollmar R,Hudspeth AJ

更新日期：2004-02-24 00:00:00

abstract：:The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SY,Asano M

更新日期：2008-08-26 00:00:00

abstract：:The Q fever bacterium Coxiella burnetii replicates inside host cells within a large Coxiella-containing vacuole (CCV) whose biogenesis relies on the Dot/Icm-dependent secretion of bacterial effectors. Several membrane trafficking pathways contribute membranes, proteins, and lipids for CCV biogenesis. These include the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martinez E,Allombert J,Cantet F,Lakhani A,Yandrapalli N,Neyret A,Norville IH,Favard C,Muriaux D,Bonazzi M

更新日期：2016-06-07 00:00:00

abstract：:The primary structure of the precursor of urotensin I, a neuropeptide hormone from the caudal neurosecretory system of the carp Cyprinus carpio, has been determined by analyzing the nucleotide sequence of cloned DNA complementary to the mRNA encoding it. The precursor consists of 145 amino acid residues and the carbox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida I,Ichikawa T,Deguchi T

更新日期：1986-01-01 00:00:00

abstract：:Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walsh ST,Cheng H,Bryson JW,Roder H,DeGrado WF

更新日期：1999-05-11 00:00:00

abstract：:The Rhizobium common nod gene products NodABC are involved in the synthesis of the core lipochitooligosaccharide (Nod factor) structure, whereas the products of the host-specific nod genes are necessary for diverse structural modifications, which vary in different Rhizobium species. The sulfate group attached to the R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultze M,Staehelin C,Röhrig H,John M,Schmidt J,Kondorosi E,Schell J,Kondorosi A

更新日期：1995-03-28 00:00:00

abstract：:Inflammation and vascular injury triggered by ischemia/reperfusion (I/R) represent a leading cause of morbidity and mortality in a number of clinical settings. Wnt and its homolog partners R-spondins, in addition to regulating embryonic development have recently been demonstrated to serve as wound-healing agents in in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan L,Kis-Toth K,Yoshiya K,Thai TH,Sehrawat S,Mayadas TN,Dalle Lucca JJ,Tsokos GC

更新日期：2013-08-27 00:00:00

abstract：:Expression of luminescence in Escherichia coli was recently achieved by cloning genes from the marine bacterium Vibrio fischeri. One DNA fragment on a hybrid plasmid encoded regulatory functions and enzymatic activities necessary for light production. We report the results of a genetic analysis to identify the lumines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engebrecht J,Silverman M

更新日期：1984-07-01 00:00:00

abstract：:Sinorhizobium meliloti is an alpha-proteobacterium that forms agronomically important N(2)-fixing root nodules in legumes. We report here the complete sequence of the largest constituent of its genome, a 62.7% GC-rich 3,654,135-bp circular chromosome. Annotation allowed assignment of a function to 59% of the 3,341 pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capela D,Barloy-Hubler F,Gouzy J,Bothe G,Ampe F,Batut J,Boistard P,Becker A,Boutry M,Cadieu E,Dréano S,Gloux S,Godrie T,Goffeau A,Kahn D,Kiss E,Lelaure V,Masuy D,Pohl T,Portetelle D,Pühler A,Purnelle B,Ramsper

更新日期：2001-08-14 00:00:00

abstract：:To investigate the molecular basis for the tissue-specific expression of the human CD2 gene, its chromatin configuration was assessed by determining DNase I hypersensitivity and the degree of methylation during T-cell lineage commitment and development. Tissue-specific DNase I-hypersensitive sites were found within th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wotton D,Flanagan BF,Owen MJ

更新日期：1989-06-01 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00

abstract：:The E1A gene of adenovirus type 5 encodes two major proteins of 289 and 243 amino acid residues, which are identical except that the larger protein has an internal stretch of 46 amino acids required for efficient trans-activation of early viral promoters. This domain contains a consensus zinc finger motif (Cys-Xaa2-Cy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Culp JS,Webster LC,Friedman DJ,Smith CL,Huang WJ,Wu FY,Rosenberg M,Ricciardi RP

更新日期：1988-09-01 00:00:00

abstract：:Antibodies to DNA in the left-handed (Z) conformation bind to acid-fixed polytene chromosomes of both Chironomus thummi and Drosophila melanogaster, as shown by direct and indirect immunofluorescence. Comparison of the phase-contrast, immunofluorescence, and DNA staining patterns shows a predominant localization of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arndt-Jovin DJ,Robert-Nicoud M,Zarling DA,Greider C,Weimer E,Jovin TM

更新日期：1983-07-01 00:00:00

abstract：:Plant viruses are submitted to narrow population bottlenecks both during infection of their hosts and during horizontal transmission between host individuals. The size of bottlenecks exerted on virus populations during plant invasion has been estimated in a few pathosystems but is not addressed yet for horizontal tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moury B,Fabre F,Senoussi R

更新日期：2007-11-06 00:00:00

abstract：:Obesity is a major public health problem and is often associated with type 2 diabetes mellitus, cardiovascular disease, and metabolic syndrome. Leptin is the crucial adipostatic hormone that controls food intake and body weight through the activation of specific leptin receptors (OB-R) in the hypothalamic arcuate nucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Couturier C,Sarkis C,Séron K,Belouzard S,Chen P,Lenain A,Corset L,Dam J,Vauthier V,Dubart A,Mallet J,Froguel P,Rouillé Y,Jockers R

更新日期：2007-12-04 00:00:00

abstract：:Mobile ectothermic animals can control their body temperatures by selecting specific thermal conditions in the environment, but embryos--trapped within an immobile egg and lacking locomotor structures--have been assumed to lack that ability. Falsifying that assumption, our experimental studies show that even early sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du WG,Zhao B,Chen Y,Shine R

更新日期：2011-06-07 00:00:00

abstract：:Organic substances can adopt an amorphous solid or semisolid state, influencing the rate of heterogeneous reactions and multiphase processes in atmospheric aerosols. Here we demonstrate how molecular diffusion in the condensed phase affects the gas uptake and chemical transformation of semisolid organic particles. Flo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shiraiwa M,Ammann M,Koop T,Pöschl U

更新日期：2011-07-05 00:00:00

abstract：:Ca(2+) is essential for physiological depolarization-evoked synchronous neurotransmitter release. But, whether Ca(2+) influx or another factor controls release initiation is still under debate. The time course of ACh release is controlled by a presynaptic inhibitory G protein-coupled autoreceptor (GPCR), whose agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kupchik YM,Rashkovan G,Ohana L,Keren-Raifman T,Dascal N,Parnas H,Parnas I

更新日期：2008-03-18 00:00:00

abstract：:Eukaryotes engage in a multitude of beneficial and deleterious interactions with bacteria. Hamiltonella defensa, an endosymbiont of aphids and other sap-feeding insects, protects its aphid host from attack by parasitoid wasps. Thus H. defensa is only conditionally beneficial to hosts, unlike ancient nutritional symbio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Degnan PH,Yu Y,Sisneros N,Wing RA,Moran NA

更新日期：2009-06-02 00:00:00

abstract：:A 37-kDa glycoprotein has been described recently, whose synthesis is dramatically increased after injury of the rat sciatic and optic nerves. Cells in the nerve sheath, distal to the site of injury, produce and secrete large amounts of this protein, so that by 3 weeks after injury, it represents 2-5% of the total sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ignatius MJ,Gebicke-Härter PJ,Skene JH,Schilling JW,Weisgraber KH,Mahley RW,Shooter EM

更新日期：1986-02-01 00:00:00

abstract：:Efficient apoptotic cell clearance and induction of immunologic tolerance is a critical mechanism preventing autoimmunity and associated pathology. Our laboratory has reported that apoptotic cells induce tolerance by a mechanism dependent on the tryptophan catabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) in sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ravishankar B,Liu H,Shinde R,Chaudhary K,Xiao W,Bradley J,Koritzinsky M,Madaio MP,McGaha TL

更新日期：2015-08-25 00:00:00

abstract：:Mutations in the GABA(A) receptor gamma2 subunit are associated with childhood absence epilepsy and febrile seizures. To understand better the molecular basis of absence epilepsy in man, we developed a mouse model harboring a gamma2 subunit point mutation (R43Q) found in a large Australian family. Mice heterozygous fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan HO,Reid CA,Single FN,Davies PJ,Chiu C,Murphy S,Clarke AL,Dibbens L,Krestel H,Mulley JC,Jones MV,Seeburg PH,Sakmann B,Berkovic SF,Sprengel R,Petrou S

更新日期：2007-10-30 00:00:00

abstract：:Development of effective chemopreventive agents against prostate cancer (CaP) for humans requires conclusive evidence of their efficacy in animal models that closely emulates human disease. The autochthonous transgenic adenocarcinoma of the mouse prostate (TRAMP) model, which spontaneously develops metastatic CaP, is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta S,Hastak K,Ahmad N,Lewin JS,Mukhtar H

更新日期：2001-08-28 00:00:00