Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules.

abstract：:Immunological reactions are influenced by various factors including antigens, antibodies and other variables. We focused on two items: i) matrix effects, especially of detergents and ii) temperature effects: preheating sera, especially effects on rheumatoid factor (RF) measurement and false-positive reactions in ELISA...

journal_title：Clinical chemistry and laboratory medicine

authors： Yoshida H,Imafuku Y,Nagai T

更新日期：2004-01-01 00:00:00

abstract：:Background Aberrant kallikrein activity is observed in a number of inflammatory dermatoses. Up-regulation of kallikrein-5 (KLK5) activity leads to uncontrolled skin desquamation and cleavage of proteinase-activated receptor-2 (PAR2), causing the release of pro-inflammatory cytokines and disruption of epidermal barrier...

journal_title：Clinical chemistry and laboratory medicine

authors： Di Paolo CT,Filippou PS,Yu Y,Poda G,Diamandis EP,Prassas I

更新日期：2019-10-25 00:00:00

abstract：BACKGROUND:This paper describes the evolution, structure, operation and some outcomes of the Brazilian Laboratory Indicators Program created by the Brazilian Society of Clinical Pathology/Laboratory Medicine (Sociedade Brasileira de Patologia Clínica/Medicina Laboratorial, or SBPC/ML), in partnership with ControlLab, a...

journal_title：Clinical chemistry and laboratory medicine

authors： Shcolnik W,de Oliveira CA,de São José AS,de Oliveira Galoro CA,Plebani M,Burnett D

更新日期：2012-11-01 00:00:00

abstract：:Iron status in man is influenced by environmental and genetic factors. The molecular variation of haptoglobin is one of the genetic factors influencing iron status in Caucasians. Differences in iron metabolism between blacks and whites have been reported. We wanted to investigate the effect of haptoglobin polymorphism...

journal_title：Clinical chemistry and laboratory medicine

authors： Kasvosve I,Gordeuk VR,Delanghe JR,Gomo ZA,Gangaidzo IT,Khumalo H,Moyo VM,Saungweme T,Mvundura E,Boelaert JR

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:DNA strand breaks are believed to induce carcinogenesis. This study was conducted to analyze induction and repair of irradiation- and chemotherapy-related strand breaks in vitro. METHODS:Friend Leukemia cells were exposed to irradiation and various chemotherapeutic agents at different doses and concentrations....

journal_title：Clinical chemistry and laboratory medicine

authors： Froelich JJ,Schneller FR,Zahn RK

更新日期：1999-04-01 00:00:00

abstract：:Volatile biomarker analysis in exhaled breath is becoming one of the desirable strategies for cancer detection because it may offer a relatively inexpensive, rapid, and non-invasive screening method for early diagnosis. Breath analysis has attracted a considerable amount of scientific and clinical interest over the pa...

journal_title：Clinical chemistry and laboratory medicine

authors： Badjagbo K

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Reference laboratories providing reference services recognized by the Joint Committee for Traceability in Laboratory Medicine (JCTLM) must be accredited as calibration laboratories according to ISO 17025 and ISO 15195. These standards require laboratories to establish an uncertainty budget, in which the unce...

journal_title：Clinical chemistry and laboratory medicine

authors： Rami L,Canalias F

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The aim of this study was to provide inter-laboratory imprecision comparisons of different groups of diagnostic systems as well as a comparison of professional laboratories with medical offices performance on the basis of 88,429 glucose results obtained in external quality assessment (EQA) schemes organized ...

journal_title：Clinical chemistry and laboratory medicine

authors： Morandi PA,Deom A,Kesseler D,Cohen R

更新日期：2010-09-01 00:00:00

abstract：:Most studies of the relation between psychological performance in the elderly and deficiencies of cobalamin and folate have used methods that determine the blood concentrations of these vitamins, which might not reflect the vitamin status in the tissues. Recently, two new markers, plasma homocysteine and methylmalonic...

journal_title：Clinical chemistry and laboratory medicine

authors： Hultberg B,Jensen E,Dehlin O,Hagberg B,Samuelsson G,Svensson T

更新日期：1999-10-01 00:00:00

abstract：:The importance of proper consumption of dietary folate for human health has been highlighted by an extensive number of publications over several decades. Fortification of grain products with folic acid was initiated with the specific intent to prevent neural tube defects, and the scope of this endeavor is unique in th...

journal_title：Clinical chemistry and laboratory medicine

authors： Strickland KC,Krupenko NI,Krupenko SA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Fatty acid metabolites play a key role in numerous physiological and pathological processes. A rapid liquid chromatography-mass spectrometry assay for the simultaneous determination of prostanoids, isoprostane and lipoxygenase (LOX) derived fatty acid metabolites in a small biological sample of only 20 micro...

journal_title：Clinical chemistry and laboratory medicine

authors： Unterwurzacher I,Koal T,Bonn GK,Weinberger KM,Ramsay SL

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Recently published data identified bone-specific alkaline phosphatase (BALP) as a good marker of bone formation in different bone diseases and osteoporosis. Two methods are available for BALP determination: one measures enzyme activity, the other its mass concentration. We compared results for BALP activity ...

journal_title：Clinical chemistry and laboratory medicine

authors： Avbersek-Luznik I,Gmeiner Stopar T,Marc J

更新日期：2007-01-01 00:00:00

abstract：:Thrombophilia can be identified in about half of all patients presenting with venous thromboembolism (VTE). Thrombophilia screening for various indications has increased tremendously, but whether the results of such tests help in the clinical management of patients is uncertain. Here, current recommendations for throm...

journal_title：Clinical chemistry and laboratory medicine

authors： Stegnar M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Placental protein-13 (PP13) is involved in placental invasion and has been suggested as a maternal serum marker of preeclampsia (PE) development. However, the discriminatory ability of PP13 in first trimester has not been completely clarified. METHODS:PP13 was measured in first trimester (week 10+3-13+6) ma...

journal_title：Clinical chemistry and laboratory medicine

authors： De Villiers CP,Hedley PL,Placing S,Wøjdemann KR,Shalmi AC,Carlsen AL,Rode L,Sundberg K,Tabor A,Christiansen M

更新日期：2017-11-27 00:00:00

abstract：BACKGROUND:Growth differentiation factor-15 (GDF-15), a stress responsive cytokine, is a promising biomarker of renal functional decline in diabetic kidney disease (DKD). This study aimed primarily to establish normative data and secondarily to evaluate the potential utility of GDF-15 in DKD using Roche Diagnostics ele...

journal_title：Clinical chemistry and laboratory medicine

authors： Hamon SM,Griffin TP,Islam MN,Wall D,Griffin MD,O'Shea PM

更新日期：2019-03-26 00:00:00

abstract：BACKGROUND:Quantification of serum free light chains (FLC) is important in the diagnosis of plasma cell diseases where an abnormal kappa:lambda ratio infers a population of monoclonal plasma cells. The Freelite™ and N Latex assays have been validated in populations without kidney disease but there is a paucity of data ...

journal_title：Clinical chemistry and laboratory medicine

authors： Kennard A,Hawley C,Tate J,Klingberg S,Pretorius C,Hutchison C,Mollee P

更新日期：2016-06-01 00:00:00

abstract：:The aim of this multicenter study was to evaluate the technical and clinical performance of the Elecsys S100 electrochemiluminescence immunoassay and to assess its utility as a tumor marker in patients with malignant melanoma. Imprecision studies yielded within-run coefficients of variation (CVs) of 0.7-2.0% and betwe...

journal_title：Clinical chemistry and laboratory medicine

authors： Alber B,Hein R,Garbe C,Caroli U,Luppa PB

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The presence of preanalytical mistakes (PM) in samples from primary care centres (PCC) is a widely studied topic. Different correcting strategies have been proposed, with variable success. We planned a series of multidisciplinary sessions for clinical update, with the aim to decrease PM rates in samples from...

journal_title：Clinical chemistry and laboratory medicine

authors： Romero A,Gómez-Salgado J,Gómez-Fernández JA,Cobos A,Ruiz-Frutos C

更新日期：2017-10-26 00:00:00

abstract：:The objective of this study was to establish reference intervals for thyroid stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), total thyronine (TT4) and total triiodothyronine (TT3) on the Architect i2000 analyser (Abbott). Serum samples were obtained from apparently healthy adults (n=217, ...

journal_title：Clinical chemistry and laboratory medicine

authors： Hubl W,Schmieder J,Gladrow E,Demant T

更新日期：2002-02-01 00:00:00

abstract：:Background Brevican, neurocan, tenascin-C and tenascin-R are extracellular matrix proteins present in brain that show increased expression in experimental animal models of brain injury. However, little is known about the dynamics of these proteins in human body fluids, such as cerebrospinal fluid (CSF) and serum, afte...

journal_title：Clinical chemistry and laboratory medicine

authors： Minta K,Cullen NC,Nimer FA,Thelin EP,Piehl F,Clarin M,Tullberg M,Jeppsson A,Portelius E,Zetterberg H,Blennow K,Andreasson U

更新日期：2019-09-25 00:00:00

abstract：:Age-related variation of the urinary excretion of amino acids has been widely reported. Instead of the conventional reference intervals, continuous reference limits might be a more practical approach during periods of rapid changes such as infancy or childhood. Regression-based reference limits have been produced for ...

journal_title：Clinical chemistry and laboratory medicine

authors： Venta R,Prieto B,Alvarez FV

更新日期：2002-04-01 00:00:00

abstract：PURPOSE:The aim of our study was to measure the inter-assay variation and accuracy of serum creatinine assays and to assess the effect of standardized calibration procedures on this variability. METHODS:We analyzed 30 human sera and three reference materials, using 17 creatinine assays (12 colorimetric, 4 enzymatic an...

journal_title：Clinical chemistry and laboratory medicine

authors： Séronie-Vivien S,Galteau MM,Carlier MC,Hadj-Aissa A,Hanser AM,Hym B,Marchal A,Michotey O,Pouteil-Noble C,Sternberg M,Perret-Liaudet A,Creatinine Working Group of the Société Française de Biologie Clinique.

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Sequencing based mutation screening assays of genes encompassing large numbers of exons could be substantially optimized by multiplex PCR, which enables simultaneous amplification of many targets in one reaction. In the present study, a multiplex PCR protocol originally developed for fragment analysis was ev...

journal_title：Clinical chemistry and laboratory medicine

authors： Horn MP,Mäder-Heinemann G,Andrey G,Largiadèr CR

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Haptoglobin (Hp) is an abundant serum protein which binds extracorpuscular hemoglobin (Hb). Two alleles exist in humans for the Hp gene, denoted 1 and 2. Diabetic individuals with the Hp 2-2 genotype are at increased risk of developing vascular complications including heart attack, stroke, and kidney disease...

journal_title：Clinical chemistry and laboratory medicine

authors： Levy NS,Vardi M,Blum S,Miller-Lotan R,Afinbinder Y,Cleary PA,Paterson AD,Bharaj B,Snell-Bergeon JK,Rewers MJ,Lache O,Levy AP

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:International recommendations highlight the superior value of cardiac troponins (cTns) for early diagnosis of myocardial infarction along with analytical requirements of improved precision and detectability. In this multicenter study, we investigated the analytical performance of a new high sensitive cardiac...

journal_title：Clinical chemistry and laboratory medicine

authors： Krintus M,Kozinski M,Boudry P,Capell NE,Köller U,Lackner K,Lefèvre G,Lennartz L,Lotz J,Herranz AM,Nybo M,Plebani M,Sandberg MB,Schratzberger W,Shih J,Skadberg Ø,Chargui AT,Zaninotto M,Sypniewska G

更新日期：2014-11-01 00:00:00

abstract：:Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The i...

journal_title：Clinical chemistry and laboratory medicine

authors： Hong YJ,Lee JK,Lee GH,Hong SI

更新日期：2000-09-01 00:00:00

abstract：:Congenital disorders of glycosylation (CDG) are genetic multisystemic diseases due to various defects in the biosynthesis or processing of glycoproteins. Our aim is to present our experience in the selective screening of CDG syndrome in a paediatric population (421 patients) with clinical suspicion of the disease, ana...

journal_title：Clinical chemistry and laboratory medicine

authors： Colomé C,Ferrer I,Artuch R,Vilaseca MA,Pineda M,Briones P

更新日期：2000-10-01 00:00:00

abstract：:Total prostate-specific antigen (PSA) and complexed PSA were determined in venous blood from 12 patients with prostate cancer before and after radical prostatectomy by using Immuno 1 PSA assays. The elimination kinetics of complexed PSA were compared with that of total PSA. Nearly constant concentrations of complexed ...

journal_title：Clinical chemistry and laboratory medicine

authors： Stephan C,Jung K,Brux B,Lein M,Sinha P,Schnorr D,Loening SA

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Cholesterol homeostasis disorders may cause dyslipidemia, atherosclerosis progression and coronary artery disease (CAD) development. Evaluation of non-cholesterol sterols (NCSs) as synthesis and absorption markers, and lipoprotein particles quality may indicate the dyslipidemia early development. This study ...

journal_title：Clinical chemistry and laboratory medicine

authors： Gojkovic T,Vladimirov S,Spasojevic-Kalimanovska V,Zeljkovic A,Vekic J,Kalimanovska-Ostric D,Djuricic I,Sobajic S,Jelic-Ivanovic Z

更新日期：2017-03-01 00:00:00

abstract：:This article provides an overview of the role of metabolite toxicity, low-grade inflammation and disturbed cellular signaling in obesity, glucose intolerance and diabetes. It also highlights links between this continuum of deteriorating glucose tolerance and atherosclerosis. Obesity, diabetes mellitus, and cardiovascu...

journal_title：Clinical chemistry and laboratory medicine

authors： Dominiczak MH

更新日期：2003-09-01 00:00:00