Abstract:
RATIONALE AND OBJECTIVES:Multireader imaging trials often use a factorial design, in which study patients undergo testing with all imaging modalities and readers interpret the results of all tests for all patients. A drawback of this design is the large number of interpretations required of each reader. Split-plot designs have been proposed as an alternative, in which one or a subset of readers interprets all images of a sample of patients, while other readers interpret the images of other samples of patients. In this paper, the authors compare three methods of analysis for the split-plot design. MATERIALS AND METHODS:Three statistical methods are presented: the Obuchowski-Rockette method modified for the split-plot design, a newly proposed marginal-mean analysis-of-variance approach, and an extension of the three-sample U-statistic method. A simulation study using the Roe-Metz model was performed to compare the type I error rate, power, and confidence interval coverage of the three test statistics. RESULTS:The type I error rates for all three methods are close to the nominal level but tend to be slightly conservative. The statistical power is nearly identical for the three methods. The coverage of 95% confidence intervals falls close to the nominal coverage for small and large sample sizes. CONCLUSIONS:The split-plot multireader, multicase study design can be statistically efficient compared to the factorial design, reducing the number of interpretations required per reader. Three methods of analysis, shown to have nominal type I error rates, similar power, and nominal confidence interval coverage, are available for this study design.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Obuchowski NA,Gallas BD,Hillis SLdoi
10.1016/j.acra.2012.09.012subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1508-17issue
12eissn
1076-6332issn
1878-4046pii
S1076-6332(12)00483-7journal_volume
19pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:Our primary aim was to improve radiology reports by increasing concordance of target lesion measurements with oncology records using radiology preprocessors (RP). Faster notification of incidental actionable findings to referring clinicians and clinical radiologist exam interpretation time savi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.09.014
更新日期:2020-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the potential use of gadolinium (Gd)-based contrast media, especially that of Gadovist, a 1-molar Gd medium, in computed tomography (CT) and compare our findings with standard iodinated contrast media. MATERIAL AND METHODS:Using a live rabbit and an acrylic CT body phantom for comp...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.03.019
更新日期:2006-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Acute and chronic graft rejection remains the major problem in clinical surveillance of lung-transplanted patients and early detection of complications is of capital importance to allow the optimal therapeutic option. The aim of this study was to investigate the role of quantitative non contras...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.05.026
更新日期:2020-07-08 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study was performed to determine physical characteristics of areas on chest radiographs that are suspicious but not definitive for the presence of a pulmonary nodule and the characteristics of areas that contain an obvious nodule. MATERIALS AND METHODS:Two groups of patients were identifi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80297-3
更新日期:1998-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We compared the performance of fast spin-echo (FSE) with conventional spin-echo (CSE) magnetic resonance (MR) imaging sequences in the detection of meniscal tears. METHODS:Seventy-three patients underwent MR examination of the knee for suspected internal derangement. Each patient was scanned w...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80166-7
更新日期:1995-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We sought to evaluate the diagnostic performance of high-resolution magnetic resonance imaging (MRI) and conventional MRI of the knee on a standard-field-strength MRI system compared to arthroscopic findings in patients with suspected meniscal tears. MATERIALS AND METHODS:Forty-two patients (2...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.02.007
更新日期:2008-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the effect of a newly developed computer-aided diagnosis (CAD) system on reader interpretation of breast lesions in automated three-dimensional (3D) breast ultrasound. MATERIALS AND METHODS:A CAD system was developed to differentiate malignant lesions from benign lesions includi...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acra.2013.07.013
更新日期:2013-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:(23)Na magnetic resonance imaging is a promising technique for the noninvasive imaging of renal function. Past investigations of the renal corticomedullary [(23)Na] gradient have relied on imaging only in the coronal plane and on cumbersome calculations of [(23)Na], which require the use of ext...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.10.009
更新日期:2013-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to determine if bronchial wall thickening is present in children with moderate to severe asthma during periods free from clinical bronchoconstriction. MATERIALS AND METHODS:The authors obtained low (radiation) dose thin-section computed tomographic (CT) scans i...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/S1076-6332(03)80535-4
更新日期:2001-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A number of studies have reported decreases in fractional anistropy (FA) in amyotrophic lateral sclerosis using diffusion tensor imaging (DTI). The purpose of this study was to perform a meta-analysis in order to estimate the diagnostic test accuracy measures of DTI for the diagnosis of amyotro...
journal_title:Academic radiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.acra.2012.04.012
更新日期:2012-09-01 00:00:00
abstract::This case study chronicles the impact of Hurricane Katrina on the Department of Radiology at the Louisiana State University School of Medicine in New Orleans and the department's subsequent efforts to recover and re-dedicate itself to providing quality patient care and resident education. Hurricane Katrina damaged the...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.01.016
更新日期:2009-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Digital chest imaging has replaced film chest radiographs in many centers, but the International Labour Organization classification system, which is the most widely used system for recognition and classification of dust-related abnormalities, is predicated on film chest radiographs. The purpose...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.12.020
更新日期:2009-06-01 00:00:00
abstract::In this article, we describe how social media can supplement traditional education, articulate the advantages and disadvantages of various social media platforms for both teachers and learners, discuss best practices to maintain confidentiality of protected health information, and provide tips for implementing social ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.12.023
更新日期:2017-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to investigate the effects of exogenous endothelial progenitor cells (EPCs) on the growth and invasiveness of glioma in vivo to provide an experimental basis for the value and safety of using magnetically labeled EPCs as target vectors to detect early infiltration of g...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.017
更新日期:2011-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Severe calcifications of the coronary arteries are still a major challenge in coronary computed tomography (CT) angiography (CCTA). Subtraction CCTA using a 320-detector row CT scanner has recently been introduced for patients with severe calcifications. However, the conventional subtraction CC...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.04.012
更新日期:2016-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Digitizing images for use in case presentations based on hardcopy films, slides, photographs, negatives, books, and videos can present a challenging task. Scanners and digital cameras have become standard tools of the trade. Unfortunately, use of these devices to digitize multiple images in man...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00010-2
更新日期:2003-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Primary dilated cardiomyopathy is a disease of unknown etiology, and it leads to severe heart failure. Abnormalities of the cardiac metabolism can play an important role in prognosis and influence the symptomatology in this group. The aim of this study was to assess cardiac metabolism using pro...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00104-1
更新日期:2003-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Morphologic changes of the human brain during healthy aging provide useful reference knowledge for age-related brain disorders. The aim of this study was to explore age-related global and regional morphological changes of healthy adult brains. MATERIALS AND METHODS:T1-weighted magnetic resonan...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.03.006
更新日期:2012-07-01 00:00:00
abstract:PURPOSE:To evaluate diagnostic accuracy and clinical outcomes of patients with porcelain gallbladder (GB) diagnosed on CT. MATERIALS AND METHODS:In this IRB-approved, HIPAA-compliant study, consecutive patients with porcelain gallbladder reported on CT between December 1, 2000 and August 31, 2017 in a tertiary academi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.07.006
更新日期:2020-08-04 00:00:00
abstract:RATIONALE AND OBJECTIVES:Emphysema is a hallmark of chronic obstructive pulmonary disease. The primary aim of this study was to investigate inter- and intraobserver agreement of visual assessment of mild emphysema in low-dose multidetector computed tomography of subjects in the pilot SCAPIS in order to certify consiste...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.06.019
更新日期:2020-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Selecting the optimal phase for coronary artery evaluation can be challenging, especially at higher heart rates, given that the optimal phase may differ for each of the coronary arteries. This study aimed to evaluate a novel vessel-specific algorithm which automatically outputs the minimum moti...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.01.013
更新日期:2015-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Tumor grading of nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) determines the choice of clinical treatment and management. The pathological grade of pancreatic neuroendocrine tumors is usually assessed on postoperative specimens. The goal of our study is to establish a tumor grade (...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.01.002
更新日期:2020-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A method is presented to track guide wires during endovascular interventions under X-ray fluoroscopy. Accurate guide wire tracking can be used to improve guide wire visualization in the low quality fluoroscopic images, and to estimate the position of the guide wire in world coordinates for navi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00539-7
更新日期:2003-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Surgical repair of an isolated orbital fracture requires anatomically accurate implant shape and placement. We describe a three-dimensional (3D) printing technique to customize the shape of commercially available absorbable implants. MATERIALS AND METHODS:We reviewed our early experience with ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.06.023
更新日期:2020-04-01 00:00:00
abstract::Continuous quality improvement methods provide a relatively new way to improve quality in healthcare by using a systems approach with key features of customer-mindedness, data collection, experimentation, and teamwork. CQI is not meant to solve simple problems but is increasingly applied in our complex healthcare orga...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/s1076-6332(03)00670-6
更新日期:2004-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Pulmonary atelectasis presumably promotes and facilitates lung injury. However, data are limited on its direct and remote relation to inflammation. We aimed to assess regional 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) kinetics representative of inflammation in atelectatic and normally aerated ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.12.022
更新日期:2020-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to examine the effects of placing a metal stent across a bronchial orifice. MATERIALS AND METHODS:Nine pigs were used as test subjects, because the right upper lobe bronchus comes directly off the trachea in these animals. One of three types of metal stents was pl...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(99)80253-0
更新日期:1999-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to determine the optimum threshold for performing computed tomographic (CT) angiography with shaded surface display (SSD). MATERIALS AND METHODS:A dedicated phantom was developed with an 8-mm luminal diameter. Each of 19 vessels had stenoses ranging from 0% to ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/S1076-6332(03)80641-4
更新日期:2001-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Pathogenic mutations in some genes elevate women's breast cancer risk, necessitating risk-reduction strategies. Unfortunately, women are underscreened for cancer risk, and when identified as potentially high risk, women seldom pursue genetic counseling or testing. To improve cancer risk managem...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.12.005
更新日期:2020-12-15 00:00:00
abstract:RATIONALE AND OBJECTIVES:Sodium and proton magnetic resonance imaging (23Na/1H-MRI) have shown that muscle and skin can store Na+ without water. In chronic renal failure and in heart failure, Na+ mobilization occurs, but is variable depending on age, dialysis vintage, and other features. Na+ storage depots have not bee...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.012
更新日期:2017-09-01 00:00:00