Visual and Quantitative Evaluation of Emphysema: A Case-Control Study of 1111 Participants in the Pilot Swedish CArdioPulmonary BioImage Study (SCAPIS).


RATIONALE AND OBJECTIVES:Emphysema is a hallmark of chronic obstructive pulmonary disease. The primary aim of this study was to investigate inter- and intraobserver agreement of visual assessment of mild emphysema in low-dose multidetector computed tomography of subjects in the pilot SCAPIS in order to certify consistent detection of mild emphysema. The secondary aim was to investigate the performance of quantitative densitometric measurements in the cohort. MATERIALS AND METHODS:Participants with emphysema (n = 100, 56 males and 44 females) reported in the electronic case report form of pilot SCAPIS and 100 matched controls (gender, age, height, and weight) without emphysema were included. To assess interobserver variability the randomized examinations were evaluated by two thoracic radiologists. For intraobserver variability three radiologists re-evaluated randomized examinations which they originally evaluated. The results were evaluated statistically by Krippendorff's α. The dataset was also assessed quantitively for % lung attenuation value -950 HU (LAV950), mean lung density and total lung volume by commercially available software. RESULTS:Emphysema was visually scored as mild and Krippendorff's α was ≥0.8 for both the inter- and intraobserver agreement regarding presence of emphysema and approaching 0.8 regarding presence and extent of emphysema by location in the upper lobes. Mean LAV950 was not different between the emphysematous and the nonemphysematous participants; 8.3% and 8.4%, respectively. CONCLUSION:The inter- and intraobserver agreement for visual detection of mild emphysema in low-dose multidetector computed tomography was good. Surprisingly, quantitative analysis could not reliably identify participants with mild emphysema, which hampers the use of automatic evaluation.


Acad Radiol


Academic radiology


Vikgren J,Khalil M,Cederlund K,Sörensen K,Boijsen M,Brandberg J,Lampa E,Sköld MC,Wollmer P,Lindberg E,Engvall JE,Bergström G,Torén K,Johnsson ÅA




Has Abstract


2020-05-01 00:00:00














  • Clinical utility of quantitative imaging.

    abstract::Quantitative imaging (QI) is increasingly applied in modern radiology practice, assisting in the clinical assessment of many patients and providing a source of biomarkers for a spectrum of diseases. QI is commonly used to inform patient diagnosis or prognosis, determine the choice of therapy, or monitor therapy respon...

    journal_title:Academic radiology

    pub_type: 杂志文章,评审


    authors: Rosenkrantz AB,Mendiratta-Lala M,Bartholmai BJ,Ganeshan D,Abramson RG,Burton KR,Yu JP,Scalzetti EM,Yankeelov TE,Subramaniam RM,Lenchik L

    更新日期:2015-01-01 00:00:00

  • Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.

    abstract:RATIONALE AND OBJECTIVES:Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morpho...

    journal_title:Academic radiology

    pub_type: 临床试验,杂志文章


    authors: Matsuoka S,Washko GR,Dransfield MT,Yamashiro T,San Jose Estepar R,Diaz A,Silverman EK,Patz S,Hatabu H

    更新日期:2010-01-01 00:00:00

  • Asymmetry analysis in rodent cerebral ischemia models.

    abstract:RATIONALE AND OBJECTIVES:An automated method for identification and segmentation of acute/subacute ischemic stroke, using the inherent bi-fold symmetry in brain images, is presented. An accurate and automated method for localization of acute ischemic stroke could provide physicians with a mechanism for early detection ...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Liu SX,Imielinska C,Laine A,Millar WS,Connolly ES,D'Ambrosio AL

    更新日期:2008-09-01 00:00:00

  • Effect of gravity on drug distribution after port-catheter implantation for hepatic arterial infusion chemotherapy: evaluation of the relationship between the injection posture and intrahepatic perfusion on fused images acquired with a combined SPECT/CT s

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    journal_title:Academic radiology

    pub_type: 临床试验,杂志文章


    authors: Tamura Y,Ikeda O,Nakasone Y,Shiraishi S,Tomiguchi S,Yamashita Y,Takamori H,Baba H

    更新日期:2009-06-01 00:00:00

  • Quantitative computed tomography analysis of local chemotherapy in liver tissue after radiofrequency ablation.

    abstract:RATIONALE AND OBJECTIVES:Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. MATERIALS AND METHODS:Polymer matrixes containing carboplatin (a platinum-containing chemotherapeutic agent) were implanted i...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Exner AA,Weinberg BD,Stowe NT,Gallacher A,Wilson DL,Haaga JR,Gao J

    更新日期:2004-12-01 00:00:00

  • 68Ga-PSMA PET/CT in Patients with Rising Prostatic-Specific Antigen After Definitive Treatment of Prostate Cancer: Detection Efficacy and Diagnostic accuracy.

    abstract:RATIONALE AND OBJECTIVES:68Ga-prostate-specific membrane antigen-11 (68Ga-PSMA-11) is a recently developed positron emission tomography (PET) tracer that can detect prostate cancer (PC) relapses and metastases with high contrast resolution. The aim of this study was to assess the detection efficacy and diagnostic accur...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Hamed MAG,Basha MAA,Ahmed H,Obaya AA,Afifi AHM,Abdelbary EH

    更新日期:2019-04-01 00:00:00

  • Diagnostic accuracy using diffusion tensor imaging in the diagnosis of ALS: a meta-analysis.

    abstract:RATIONALE AND OBJECTIVES:A number of studies have reported decreases in fractional anistropy (FA) in amyotrophic lateral sclerosis using diffusion tensor imaging (DTI). The purpose of this study was to perform a meta-analysis in order to estimate the diagnostic test accuracy measures of DTI for the diagnosis of amyotro...

    journal_title:Academic radiology

    pub_type: 杂志文章,meta分析


    authors: Foerster BR,Dwamena BA,Petrou M,Carlos RC,Callaghan BC,Pomper MG

    更新日期:2012-09-01 00:00:00

  • Inflammatory breast carcinoma in magnetic resonance imaging: a comparison with locally advanced breast cancer.

    abstract:RATIONALE AND OBJECTIVES:Although inflammatory breast carcinoma (IBC) accounts for 1%-4% of all breast cancer cases, the appearance of this highly malignant tumor in magnetic resonance imaging (MRI) is still not well characterized. The aim of this study was to identify typical imaging features of IBC in comparison with...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Renz DM,Baltzer PA,Böttcher J,Thaher F,Gajda M,Camara O,Runnebaum IB,Kaiser WA

    更新日期:2008-02-01 00:00:00

  • Discriminating Depth of Response to Therapy in Multiple Myeloma Using Whole-body Diffusion-weighted MRI with Apparent Diffusion Coefficient: Preliminary Results From a Single-center Study.

    abstract:RATIONALE AND OBJECTIVES:This study aimed to measure apparent diffusion coefficient (ADC) in Chinese patients with newly diagnosed multiple myeloma by whole-body diffusion-weighted magnetic resonance imaging (WB-DWI MRI) and assess the diagnostic accuracy of ADC in the discrimination of deep response to induction chemo...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Wu C,Huang J,Xu WB,Guan YJ,Ling HW,Mi JQ,Yan H

    更新日期:2018-07-01 00:00:00

  • Coregistration of Preoperative MRI with Ex Vivo Mesorectal Pathology Specimens to Spatially Map Post-treatment Changes in Rectal Cancer Onto In Vivo Imaging: Preliminary Findings.

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Antunes J,Viswanath S,Brady JT,Crawshaw B,Ros P,Steele S,Delaney CP,Paspulati R,Willis J,Madabhushi A

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  • Pulmonary functional magnetic resonance imaging: asthma temporal-spatial maps.

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Svenningsen S,Guo F,Kirby M,Choy S,Wheatley A,McCormack DG,Parraga G

    更新日期:2014-11-01 00:00:00

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Gaetke-Udager K,McLean K,Sciallis AP,Alves T,Maturen KE,Mervak BM,Moore AG,Wasnik AP,Erba J,Davenport MS

    更新日期:2016-10-01 00:00:00

  • How Well Does Dual-energy CT with Fast Kilovoltage Switching Quantify CT Number and Iodine and Calcium Concentrations?

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Ohira S,Karino T,Ueda Y,Nitta Y,Kanayama N,Miyazaki M,Koizumi M,Teshima T

    更新日期:2018-04-01 00:00:00

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Bandos AI,Rockette HE,Gur D

    更新日期:2006-04-01 00:00:00

  • LSU Health Sciences Center New Orleans Department of Radiology: effects of Hurricane Katrina.

    abstract::This case study chronicles the impact of Hurricane Katrina on the Department of Radiology at the Louisiana State University School of Medicine in New Orleans and the department's subsequent efforts to recover and re-dedicate itself to providing quality patient care and resident education. Hurricane Katrina damaged the...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Duggal A,Letourneau JG,Bok LR

    更新日期:2009-05-01 00:00:00

  • Combining Washout and Noncontrast Data From Adrenal Protocol CT: Improving Diagnostic Performance.

    abstract:RATIONALE AND OBJECTIVES:To determine if combination of washout and noncontrast data from delayed adrenal computed tomography (CT) improves diagnostic performance, and demonstration of an optimizing analytical framework. MATERIALS AND METHODS:This retrospective study consisted of 97 adrenal lesions, in 96 patients, wi...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Ng CS,Altinmakas E,Wei W,Ghosh P,Li X,Grubbs EG,Perrier NA,Prieto VG,Lee JE,Hobbs BP

    更新日期:2018-07-01 00:00:00

  • Role of intracellular calcium stores in contrast medium-induced renal vasoconstriction.

    abstract:RATIONALE AND OBJECTIVES:Renovascular smooth muscle contractility, an important factor in contrast media-induced nephrotoxicity, depends on intracellular Ca2+ concentration, which is composed of extracellular Ca2+ influx and intracellular Ca2+ release. These factors were investigated in contrast media-induced renal vas...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Drescher P,Rauch D,Madsen PO

    更新日期:1996-11-01 00:00:00

  • Reliability and Validity of Abdominal Skeletal Muscle Area Measurement Using Magnetic Resonance Imaging.

    abstract:RATIONALE AND OBJECTIVES:Skeletal muscle mass measurement is the most important element for diagnosing sarcopenia. MRI has an excellent soft-tissue contrast, which can non-invasively assess abdominal skeletal muscle area (SMA) as well as CT. This study aimed to assess the validity and reliability of abdominal SMA measu...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Wang FZ,Sun H,Zhou J,Sun LL,Pan SN

    更新日期:2020-10-28 00:00:00

  • MR Diffusion Tractography to Identify and Characterize Microstructural White Matter Tract Changes in Systemic Lupus Erythematosus Patients.

    abstract:PURPOSE:Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25-70% of SLE patients. Using diffusion tensor imaging, various studies have reported changes in white matter integrity in SLE patients with neuropsy...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Shastri R,Shah G,Wang P,Cagnoli P,Schmidt-Wilcke T,McCune J,Harris R,Sundgren P

    更新日期:2016-11-01 00:00:00

  • Cerebrospinal Fluid Amyloid Beta, Tau Levels, Apolipoprotein, and 1H-MRS Brain Metabolites in Alzheimer's Disease: A Systematic Review.

    abstract:BACKGROUND:There is compelling evidence that neurochemical changes measured by proton magnetic resonance spectroscopy (1H-MRS) occur at different phases of Alzheimer's disease (AD). However, the extent to which these neurochemical changes are associated with validated AD biomarkers and/or apolipoprotein (APOE) ε4 is ye...

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    authors: Piersson AD,Mohamad M,Rajab F,Suppiah S

    更新日期:2020-07-07 00:00:00

  • Three-dimensional human airway segmentation methods for clinical virtual bronchoscopy.

    abstract:RATIONALE AND OBJECTIVES:The segmentation of airways from CT images is a critical first step for numerous virtual bronchoscopic (VB) applications. Automatic or semiautomatic methods are necessary, since manual segmentation is prohibitively time consuming. The methods must be robust and operate within a reasonable time ...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Kiraly AP,Higgins WE,McLennan G,Hoffman EA,Reinhardt JM

    更新日期:2002-10-01 00:00:00

  • Optimal ECG trigger point in electron-beam CT studies: three methods for minimizing motion artifacts.

    abstract:RATIONALE AND OBJECTIVES:The authors hypothesized that electrocardiographic triggering near end systole could minimize motion artifacts in electron-beam computed tomography (CT) of the coronary artery. MATERIALS AND METHODS:The study included 2,660 patients who underwent coronary artery calcium scanning with electron-...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Mao S,Budoff MJ,Bin L,Liu SC

    更新日期:2001-11-01 00:00:00

  • High-resolution MR imaging of the human eye 2005.

    abstract:RATIONALE AND OBJECTIVES:We studied preparatory strategies for high-resolution human eye in vivo imaging with commercially available magnets and coils. MATERIALS AND METHODS:We imaged normal volunteers on 1.5T systems by Philips, GE, and Siemens, using commercial approximately 9 cm temporomandibular joint receive coil...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Bert RJ,Patz S,Ossiani M,Caruthers SD,Jara H,Krejza J,Freddo T

    更新日期:2006-03-01 00:00:00

  • Using the Analytic Hierarchy Process for Prioritizing Imaging Tests in Diagnosis of Suspected Appendicitis.

    abstract:RATIONALE AND OBJECTIVES:In clinical guideline or criteria development processes, such as those used in developing American College of Radiology Appropriateness Criteria (ACR AC), experts subjectively evaluate benefits and risks associated with imaging tests and make complex decisions about imaging recommendations. The...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Agapova M,Bresnahan BW,Linnau KF,Garrison LP Jr,Higashi M,Kessler L,Devine B

    更新日期:2017-05-01 00:00:00

  • Impact of COVID-19 Workflow Changes on Patient Throughput at Outpatient Imaging Centers.

    abstract:RATIONALE AND OBJECTIVES:To determine the impact of COVID-19 workflow changes on patient throughput at the outpatient imaging facilities of a large healthcare system in New York City. MATERIALS AND METHODS:COVID-19 workflow changes to permit social distancing and patient and staff safety included screening at the time...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Chang G,Doshi A,Chandarana H,Recht M

    更新日期:2021-01-04 00:00:00

  • MRI of right atrial function after catheter ablation of atrial flutter.

    abstract:RATIONALE AND OBJECTIVES:Catheter ablation of the cavotricuspid isthmus (CTI) is an effective treatment of right atrial flutter. The objective of this study was to evaluate the changes in CTI length and right atrial (RA) function after radiofrequency ablation of isthmus-dependent atrial flutter (isthmus ablation). MAT...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Ozgun M,Kirchhof P,Bunck AC,Heindel W,Eckardt L,Maintz D

    更新日期:2010-07-01 00:00:00

  • Attenuation of contrast material-induced renal artery vasoconstriction by nitric oxide donors.

    abstract:RATIONALE AND OBJECTIVES:The authors studied the role of the endothelium and associated endothelial pathways in contrast material-induced renal vasoconstriction. MATERIALS AND METHODS:Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine an...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Drescher P,Madsen PO

    更新日期:1997-12-01 00:00:00

  • A robust method for estimating regional pulmonary parameters in presence of noise.

    abstract:RATIONALE AND OBJECTIVES:Estimation of regional lung function parameters from hyperpolarized gas magnetic resonance images can be very sensitive to presence of noise. Clustering pixels and averaging over the resulting groups is an effective method for reducing the effects of noise in these images, commonly performed by...

    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Guyer RA,Hellman MD,Emami K,Kadlecek S,Cadman RV,Yu J,Vadhat V,Ishii M,Woodburn JM,Law M,Rizi RR

    更新日期:2008-06-01 00:00:00

  • Multiphase contrast medium injection for optimization of computed tomographic coronary angiography.

    abstract:RATIONALE AND OBJECTIVES:Electron beam angiography is a minimally invasive imaging technique. Adequate vascular opacification throughout the study remains a critical issue for image quality. We hypothesized that vascular image opacification and uniformity of vascular enhancement between slices can be improved using mul...

    journal_title:Academic radiology

    pub_type: 杂志文章,随机对照试验


    authors: Budoff MJ,Shinbane JS,Child J,Carson S,Chau A,Liu SH,Mao S

    更新日期:2006-02-01 00:00:00

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    journal_title:Academic radiology

    pub_type: 杂志文章


    authors: Choi H,Choi SR,Zhou R,Kung HF,Chen IW

    更新日期:2004-09-01 00:00:00