Abstract:
RATIONALE AND OBJECTIVES:It was hypothesized that perfusion computed tomography (CT), blood flow (BF), blood volume (BV), and vascular permeability surface area (PS) product parameters would be predictive of therapeutic anticancer agent uptake in pancreatic cancer, facilitating image-guided interpretation of human treatments. The hypothesis was tested in an orthotopic rabbit model of pancreatic cancer, by establishing the model, imaging with endoscopic ultrasound (EUS) and contrast CT, and spatially comparing the perfusion maps to the ex vivo uptake values of the injected photosensitizer, verteporfin. MATERIALS AND METHODS:Nine New Zealand white rabbits underwent direct pancreas implantation of VX2 tumors, and CT perfusion or EUS was performed 10 days postimplantation. Verteporfin was injected during CT imaging, and the tissue was removed 1 hour postinjection for frozen tissue fluorescence scanning. Region-of-interest comparisons of CT data with ex vivo fluorescence and histopathologic staining were performed. RESULTS:Dynamic contrast-enhanced CT showed enhanced BF, BV, and PS in the tumor rim and decreased BF, BV, and PS in the tumor core. Significant correlations were found between ex vivo verteporfin concentration and each of BF, BV, and PS. CONCLUSIONS:The efficacy of verteporfin delivery in tumors is estimated by perfusion CT, providing a noninvasive method of mapping photosensitizer dose.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Elliott JT,Samkoe KS,Gunn JR,Stewart EE,Gardner TB,Tichauer KM,Lee TY,Hoopes PJ,Pereira SP,Hasan T,Pogue BWdoi
10.1016/j.acra.2014.12.014subject
Has Abstractpub_date
2015-05-01 00:00:00pages
572-9issue
5eissn
1076-6332issn
1878-4046pii
S1076-6332(15)00004-5journal_volume
22pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:A survey was administered to fourth-year radiology residents after receiving their results from the first American Board of Radiology (ABR) Core examination in 2013. The purpose was to gather information regarding resources and study strategies to share with program directors and future residen...
journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章,随机对照试验
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abstract:RATIONALE AND OBJECTIVES:To evaluate the ability of dynamic contrast-enhanced magnetic resonance imaging (MRI) to differentiate several tumor entities of the parotid gland in a prospective clinical trial. MATERIALS AND METHODS:A total of 112 patients with parotid tumors were examined with dynamic contrast-enhanced 1.5...
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pub_type: 临床试验,杂志文章
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abstract:RATIONALE AND OBJECTIVES:To investigate the correlation between prevalence and degree of coronary artery calcification (CAC) and extracoronary calcifications (ECCs), scored quantitatively according to Agatston and semiquantitatively by visual analysis, in chest computed tomography (CT) studies obtained for lung cancer ...
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-05-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2009-07-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Academic radiology
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更新日期:2020-04-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2004-08-01 00:00:00
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journal_title:Academic radiology
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