Abstract:
RATIONALE AND OBJECTIVES:To investigate the correlation between prevalence and degree of coronary artery calcification (CAC) and extracoronary calcifications (ECCs), scored quantitatively according to Agatston and semiquantitatively by visual analysis, in chest computed tomography (CT) studies obtained for lung cancer screening in asymptomatic subjects and in patients with known coronary heart disease (CHD), and to compare the association of ECC and CAC to established cardiovascular risk factors. MATERIALS AND METHODS:Prospective study on 501 males (67 ± 8 years) with a history of working dust exposure who underwent nongated low-dose chest CT for lung cancer screening. Of these, 63 (12.6%) had a history of CHD, the remaining 438 subjects (87.4%) were clinically asymptomatic and without a history of CHD. On the day of the CT study, subjects underwent a thorough clinical examination including blood tests and completed a standardized questionnaire to establish a complete medical history. ECC and CAC scores were quantified according to Agatston and, in addition, by visual rating of calcium load of individual vessel territories on a five-point scale from "absent" to "extensive." Results were correlated with the respective subjects' cardiovascular risk factors and with the presence or absence of CHD. RESULTS:ECC scores correlated significantly with CAC scores (two-sided Spearman 0.515; P < .001). ECC scores were associated significantly (P < .001) with cardiovascular risk factors (smoking history, hypertension, diabetes, and hypercholesterolemia) and with subjects' Framingham/prospective cardiovascular münster study scores, whereas CAC scores were associated only with the presence of hypercholesterolemia. CAC scores were strongly associated with CHD than ECC scores (area under the curve, 0.88 vs. 0.66 at receiver operating characteristic analysis). Visual scoring of ECC/CAC load correlated closely with the respective Agatston values (P < .001) and revealed the same association (or lack thereof) with cardiovascular risk factors/CHD. CONCLUSIONS:In nongated low-dose CT for lung cancer screening, CAC and ECC load can be accurately established by visual analysis. ECC and CAC scores correlate closely, but not perfectly. There is a strong association between established cardiovascular risk factors and ECC load, but not CAC load, providing further evidence that ECC scoring may complement CAC scoring for broader risk assessment, for example, regarding prediction of extracoronary vascular events.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Dirrichs T,Penzkofer T,Reinartz SD,Kraus T,Mahnken AH,Kuhl CKdoi
10.1016/j.acra.2015.03.005subject
Has Abstractpub_date
2015-07-01 00:00:00pages
880-9issue
7eissn
1076-6332issn
1878-4046pii
S1076-6332(15)00118-Xjournal_volume
22pub_type
杂志文章,评审abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to measure the effect of distractions, in the form of telephone call interruptions, on radiology resident diagnostic accuracy. MATERIALS AND METHODS:Radiology resident discrepancy reports and reading room telephone logs at an academic tertiary care pediatric hospi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.08.001
更新日期:2014-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine graduating medical students' perceptions of radiology and to document changes in their perceptions since they entered medical school. MATERIALS AND METHODS:A survey questionnaire was distributed to 213 graduating students. Questions were similar to those answered by the same group...
journal_title:Academic radiology
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journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.08.002
更新日期:2014-11-01 00:00:00
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更新日期:2017-03-01 00:00:00
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更新日期:2020-05-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2020-08-08 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2005-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.acra.2017.09.015
更新日期:2018-03-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.10.008
更新日期:2012-02-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2014.08.011
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To investigate the correlation between dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) parameters and angiogenesis and to explore prospectively the feasibility of using DSC-MRI to differentiate malignant from benign soft tissue tumors (STTs) in limbs. METHODS:This prospective study inclu...
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pub_type: 杂志文章,多中心研究
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journal_title:Academic radiology
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更新日期:2010-09-01 00:00:00
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更新日期:2003-07-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2010-05-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2020-12-03 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2013.10.010
更新日期:2014-02-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00