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A comparison of mean displacement values using high b-value Q-space diffusion-weighted MRI with conventional apparent diffusion coefficients in patients with stroke.

Abstract：

RATIONALE AND OBJECTIVES:Q-space analysis using high b-value diffusion-weighted magnetic resonance (MR) data provides information on tissue microstructure in contrast to conventional MR imaging (MRI) based on low b-value diffusion-weighted imaging (DWI). The purpose of this study was to evaluate the use of mean displacement (MDP) map in stroke patients using q-space diffusion-weighted MRI (QSI). MATERIALS AND METHODS:Twenty-one patients presenting with a total of 22 acute or subacute cerebral infarctions were included. MR protocol consisted of conventional MR sequences, DWI (b-value; 1000 s/mm(2)) and QSI (b-value; maximum 12,000 s/mm(2)). Apparent diffusion coefficient (ADC) maps of conventional DWI and MDP maps of QSI data were obtained and compared in the ischemic lesions and corresponding normal tissues. RESULTS:Decreased ADC values were present in all lesions. There was no correlation between ADC and MDP values in the lesions (r = 0.21). MDP values of the lesions were 8.60 ± 1.26 μm (mean ± SD). Most of the lesions (16/22) had higher MDP values than normal brain tissue. Three lesions showed lower MDP values and three showed mixed MDP values. CONCLUSIONS:The MDP maps using QSI data provides additional information for stroke patients compared to conventional DWI.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Hori M,Motosugi U,Fatima Z,Kumagai H,Ikenaga S,Ishigame K,Aoki S,Onodera T,Yagi K,Araki T

doi

10.1016/j.acra.2011.02.005

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

837-41

issue

7

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(11)00075-4

journal_volume

18

pub_type

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