Abstract：
RATIONALE AND OBJECTIVE:Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains. MATERIALS AND METHODS:We used a set of skull-stripped brains from an image database of cranial magnetic resonance images. We then deformed a template brain to the rest of the brains creating a set of deformation fields. Using the Jacobian values of these deformation fields, we calculated the voxel-wise t-score for comparison of controls with patients. We also calculated the voxel-wise Pearson correlation of Jacobian with age for both controls and patients. RESULTS:By examining the volume renderings of these statistical fields, we found that healthy people undergo age-related expansion of the ventricles, the surrounding periventricular white matter, and a corresponding decline in the frontal lobes and cingulate gyrus. In contrast, patients show much less of this age-related expansion of the ventricles and less atrophy in the cerebral cortex. In addition, patients have larger ventricles and reduced volume in the frontal/parietal lobes. CONCLUSION:These constellations of findings suggest that otherwise normal age-related ventricular enlargement and cortical loss occurs in schizophrenia patients, albeit at an earlier age.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Dubb A,Xie Z,Gur R,Gur R,Gee Jdoi
10.1016/j.acra.2004.06.009keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
3-9issue
1eissn
1076-6332issn
1878-4046pii
S1076-6332(04)00652-Xjournal_volume
12pub_type
杂志文章abstract：RATIONALE AND OBJECTIVES:Test sets for assessing and improving radiologic image interpretation have been used for decades and typically evaluate performance relative to gold standard interpretations by experts. To assess test sets for screening mammography, a gold standard for whether a woman should be recalled for add...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2013.01.012
更新日期：2013-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Urinary calculi are now commonly detected with helical computed tomography (CT), and it has been proposed that stone composition can be determined from CT attenuation values. However, typical scans are made with a beam collimation of 5 mm or more, resulting in volume averaging and reduction in ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/S1076-6332(03)80619-0
更新日期：2001-06-01 00:00:00
abstract：:The three missions of academic radiology compete with one another for time and funding. Revenue for the clinical mission often subsidizes education and research. Given the internal and external drivers/pressures on health care and, more particularly, on academic health centers, the current model is unsustainable. Tren...
journal_title：Academic radiology
pub_type： 杂志文章,评审
doi：10.1016/j.acra.2013.04.003
更新日期：2013-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Computed tomography (CT) airways measurements can be used as surrogates to spirometric measurements for assessing bronchodilation in a particular patient with chronic obstructive pulmonary disease. Although spirometric measurements show variations within the opening hours of a hospital departme...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2018.02.024
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Systemic lupus erythematosus (SLE) is a predominantly female autoimmune disease that can affect the central nervous system. Neuropsychiatric symptoms are found in 25-70% of SLE patients. Using diffusion tensor imaging, various studies have reported changes in white matter integrity in SLE patients with neuropsy...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2016.03.019
更新日期：2016-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We compared the performance of fast spin-echo (FSE) with conventional spin-echo (CSE) magnetic resonance (MR) imaging sequences in the detection of meniscal tears. METHODS:Seventy-three patients underwent MR examination of the knee for suspected internal derangement. Each patient was scanned w...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(05)80166-7
更新日期：1995-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The goal of this prospective, interinstitutional study was to compare the long-term instructional effectiveness of a pediatric multimedia textbook (MMTB) to that of a standard lecture and a printed textbook. MATERIALS AND METHODS:A randomized cohort of 89 3rd-year medical students from two ins...
journal_title：Academic radiology
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To investigate the effect of a newly developed computer-aided diagnosis (CAD) system on reader interpretation of breast lesions in automated three-dimensional (3D) breast ultrasound. MATERIALS AND METHODS:A CAD system was developed to differentiate malignant lesions from benign lesions includi...
journal_title：Academic radiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.acra.2013.07.013
更新日期：2013-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Improvements in imaging technology have led to the increased use of computed tomography (CT). For example, micro-CT and quantitative CT (QCT) are now often used in osteoporosis research, in which micro-CT is able to analyze small bones or bone samples with high spatial resolution. In contrast, ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2008.09.017
更新日期：2009-04-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To investigate the capability of delta-radiomics to predict pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS:This retrospective study enrolled 165 consecutive patients with LARC (traini...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.10.026
更新日期：2020-11-11 00:00:00
abstract：RATIONALE AND OBJECTIVES:Balloon dilatation is a mechanical form of controlled injury used to alleviate vascular stenoses. Several factors influence successful angioplasty. Few mechanical models exist to illustrate the physical principles of balloon dilatation. METHODS:We used mechanical analysis of membrane stresses,...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(05)80340-x
更新日期：1995-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The aim of this study was to prospectively examine the impact of a tablet-based curriculum on the radiology resident educational experience. MATERIALS AND METHODS:A comprehensive tablet-based curriculum was developed by creating subspecialty modules with appropriate content level for each requ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2018.05.018
更新日期：2018-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Comprehensive training in cardiac imaging during radiology residency is imperative if radiologists are to maintain a significant role in this rapidly growing field. In this study, radiology chief residents were surveyed to assess the current status of cardiac imaging training in radiology resid...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2010.02.002
更新日期：2010-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Several methods have been proposed for calculating the variances and covariances of nonparametric estimates of the area under receiver operating characteristic curves (AUC). The authors provide an explanation of the relationships between them and illustrate the factors that determine sampling v...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(97)80161-4
更新日期：1997-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The increasing use of computed tomography (CT) has been accompanied by rising concerns over potential radiation-related health risks, especially cancer, and a need to minimize such risks. MATERIALS AND METHODS:We conducted 2186 low-dose helical chest CT scans among 1235 nuclear weapons workers...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2011.09.015
更新日期：2012-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To quantify the use of Diagnostic Certainty Phrases (DCP) in radiology reports, including DCPs with good agreement (including "diagnostic of," "unlikely" and "represents") in connoting degree of certainty between providers based on previous studies; and to assess whether modality, presence of a...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2018.10.017
更新日期：2019-09-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:SYNTAX score is a useful metric determined at the time of invasive coronary angiography (ICA) to assess the complexity of coronary artery disease, and improves prediction of complications at the time of percutaneous complex intervention (PCI). We aimed to determine whether SYNTAX score can be r...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2016.07.003
更新日期：2016-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The authors compared diagnostic accuracy and callback rates with conventional screen-film mammograms and wavelet-compressed digitized images. MATERIALS AND METHODS:Sixty sets of mammograms (four views per case) were digitized at a spatial resolution of 100 microm. The images were wavelet compr...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(00)80004-5
更新日期：2000-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The aim of the study is to develop a theory-based signal calibration approach to be used for the conversion of signal-time curves to absolute contrast concentration-time curves for first-pass contrast-enhanced quantitative myocardial perfusion studies. MATERIALS AND METHODS:A normalization pro...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2006.02.040
更新日期：2006-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Inguinal lymph nodes can be the first or the only clinical signs of tumor metastases. The aim of the study was to evaluate the role of contrast-enhanced high-resolution magnetic resonance (MR) lymphangiography in diagnosis of inguinal lymph node metastases. MATERIALS AND METHODS:The study enro...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2012.09.014
更新日期：2013-02-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Designed to provide broad-based training in all aspects of imaging, the diagnostic radiology residency program must provide educational experiences that not only provide technical training, but also meet accreditation standards. With the breadth of material to cover during training, carefully o...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.12.022
更新日期：2021-01-21 00:00:00
abstract：RATIONALE AND OBJECTIVES:The authors performed this study to assess the performance of a computer-based classification system that uses gaze locations of observers to define the subspace for machine learning. MATERIALS AND METHODS:Thirty-two dental radiographs were classified by an expert viewer into four categories o...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/S1076-6332(03)80706-7
更新日期：2001-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of occult invasive disease for patients showing ductal carcinoma in situ (DCIS) only in core biopsy. MATERIALS AND METHODS:In this retrospective study, we analyzed ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2017.03.013
更新日期：2017-09-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic resonance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries - chondral defect treatment by microfractures and scaffold implantation in combinat...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.05.030
更新日期：2020-06-30 00:00:00
abstract：:This paper outlines the efforts of the American College of Radiology to understand the public perception of radiologists and to effect change in that perception. Through focus groups, in-depth interviews with Capitol Hill staff members, and national telephone surveys, it was found that the public is unaware of the edu...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2009.02.003
更新日期：2009-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We report social media (SoMe) utilization trends at an academic radiology department, highlighting differences between trainees and faculty and between Baby Boomers versus Generation X and Millennials. MATERIALS AND METHODS:An anonymous online survey regarding SoMe utilization and SoMe-based e...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2017.08.012
更新日期：2018-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:In clinical guideline or criteria development processes, such as those used in developing American College of Radiology Appropriateness Criteria (ACR AC), experts subjectively evaluate benefits and risks associated with imaging tests and make complex decisions about imaging recommendations. The...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2017.01.001
更新日期：2017-05-01 00:00:00
abstract：RATIONAL AND OBJECTIVES:Computer-aided detection (CAD) systems are intended to improve performance. This study investigates how CAD might actually interfere with a visual search task. This is a laboratory study with implications for clinical use of CAD. METHODS:Forty-seven naive observers in two studies were asked to ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2012.05.013
更新日期：2012-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Since the initial description of an intralobar attenuation gradient by Webb et al, it has been suggested that departure from the intralobar attenuation gradient could indicate early lung diseases. However, its significance has not been determined in detail. We aimed to quantify the anteroposter...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2005.10.025
更新日期：2006-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Magnetic resonance (MR) imaging is used to assess brain tumor response to therapies, and a MR quality assurance (QA) program is necessary for multicenter clinical trials employing imaging. This study was performed to determine overall variability of quantitative imaging metrics measured with th...
journal_title：Academic radiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.acra.2008.04.004
更新日期：2008-09-01 00:00:00
