Abstract：
RATIONALE AND OBJECTIVES:To determine whether quantitative dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) features can discriminate malignant from benign axillary lymph nodes (ALNs) identified as suspicious on clinical breast MRI in patients newly diagnosed with breast cancer. MATERIALS AND METHODS:After approval from institutional review board, all clinical breast MR examinations performed from March 2006 through January 2010 describing at least one morphologically suspicious ipsilateral ALN in patients with newly diagnosed breast cancer were identified. Each suspicious ALN underwent ultrasound-guided core needle biopsy, and nodes with benign results were subsequently sampled surgically. Quantitative DCE and DW MRI parameters (diameters, volume, enhancement kinetics, and apparent diffusion coefficients [ADC]) were measured for each suspicious ALN and a representative contralateral normal node, and each feature was compared between the ALN groups (normal, benign, and malignant). RESULTS:Thirty-four suspicious ALNs (18 malignant and 16 benign) and 34 contralateral normal-appearing ALNs were included. Suspicious malignant and benign nodes exhibited larger size, greater volume, and lower ADCs than normal ALNs (P < .05). Among suspicious ALNs, the only quantitative measure that discriminated between malignant from benign outcome was percent of ALN demonstrating washout kinetics (P = .02). CONCLUSIONS:In ALNs deemed morphologically suspicious on breast MRI, quantitative MRI features show little value in identifying those with malignant etiology.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Rahbar H,Conlin JL,Parsian S,DeMartini WB,Peacock S,Lehman CD,Partridge SCdoi
10.1016/j.acra.2014.10.010subject
Has Abstractpub_date
2015-04-01 00:00:00pages
430-8issue
4eissn
1076-6332issn
1878-4046pii
S1076-6332(14)00401-2journal_volume
22pub_type
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journal_title：Academic radiology
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journal_title：Academic radiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type： 杂志文章,评审
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更新日期：2020-12-29 00:00:00
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更新日期：2020-05-01 00:00:00
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更新日期：2008-12-01 00:00:00
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journal_title：Academic radiology
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更新日期：2007-10-01 00:00:00
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更新日期：2020-08-04 00:00:00
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journal_title：Academic radiology
pub_type： 杂志文章
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更新日期：2013-04-01 00:00:00
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journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/S1076-6332(03)80706-7
更新日期：2001-12-01 00:00:00
