Abstract:
OBJECTIVES AND RATIONALE:Medulloblastoma/primitive neuroectodermal tumor (MB/PNET) is the most common malignant tumor of the central nervous system (CNS) in children. MB/PNET survivors are at an increased risk for developing second malignancies. Little has been reported on development of low-grade lesions of the calvarium in the radiation field in MB/PNET survivors. The purpose of this study was to assess the frequency of the low-grade bone lesion development in the radiotherapy field in pediatric MB/PNET survivors and describe the imaging characteristics of these lesions. MATERIALS AND METHODS:Institutional review board approval was obtained for this retrospective review which was compliant with Health Insurance Portability and Accountability Act. Forty-one MB/PNET patients (29 male) who survived for at least 2 years after initiation of radiation therapy were included. The medical records were reviewed. The most recent available brain magnetic resonance imaging studies were evaluated. RESULTS:Three patients (7.3%) developed low-grade calvarial lesions and underwent resection and/or biopsy of the lesions. There were one Langerhans cell histiocytosis, one benign spindle cell lesion with myxoid change, and one fibrous dysplasia. CONCLUSION:Development of low-grade bone lesions of calvarium is not very rare in pediatric PNET/MB survivors. Bones in the radiation therapy field need to be carefully examined for assessment of secondary lesions.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Koral K,Roy D,Timmons CF,Gargan L,Bowers DCdoi
10.1016/j.acra.2011.08.018subject
Has Abstractpub_date
2012-01-01 00:00:00pages
35-9issue
1eissn
1076-6332issn
1878-4046pii
S1076-6332(11)00439-9journal_volume
19pub_type
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