Micro-CT imaging with a hepatocyte-selective contrast agent for detecting liver metastasis in living mice.

Abstract:

RATIONALE AND OBJECTIVES:Micro-computed tomography (CT) is a important tool for longitudinal imaging of tumor development. The detection and monitoring of tumors in the liver in live animals using micro-CT is challenging. We evaluated the feasibility of high-resolution micro-CT enhanced with a hepatocyte-selective contrast agent for detecting liver metastases in a live murine model. MATERIALS AND METHODS:Hepatic metastases were induced in 10 BALB/C mice. Two mice each were randomly selected on days 3, 5, 7, 10, and 13 after CT26 colon adenocarcinoma cells were injected into the portal vein; micro-CT imaging was performed at 10 minutes and 4 hours after intravenous administration of a hepatocyte-selective contrast agent at a dose of 0.4 mL/mouse. The attenuation values of the normal liver and the tumors were obtained. The number of metastases was counted and their sizes were measured on the micro-CT images. Gross or histopathologic evaluation was performed for correlating the liver tumors with the micro-CT images. RESULTS:A total of 74 separate tumor sites larger than 300 microm in diameter were detected on pathologic examination of the mice that were sacrificed 7 days after cell injection. On micro-CT, 66 of 74 tumors were detected (83.8%). The smallest tumor detected on micro-CT was 300 microm. There were eight false-negative readings on micro-CT. The sizes of the individual liver metastases measured by micro-CT and on the excised specimen were highly correlated (P < .001). The correlation between the CT scan measurement and the actual measurement was r = 0.8354 (P < .0001). CONCLUSIONS:High-resolution micro-CT enhanced with a hepatocyte-selective contrast agent can be a promising tool for detecting liver metastases in a live murine model.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Kim HW,Cai QY,Jun HY,Chon KS,Park SH,Byun SJ,Lee MS,Oh JM,Kim HS,Yoon KH

doi

10.1016/j.acra.2008.03.021

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

1282-90

issue

10

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(08)00282-1

journal_volume

15

pub_type

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