Usefulness of 1H MR spectroscopy in the evaluation of myocardial metabolism in patients with dilated idiopathic cardiomyopathy: pilot study.

Abstract:

RATIONALE AND OBJECTIVES:Primary dilated cardiomyopathy is a disease of unknown etiology, and it leads to severe heart failure. Abnormalities of the cardiac metabolism can play an important role in prognosis and influence the symptomatology in this group. The aim of this study was to assess cardiac metabolism using proton spectroscopy magnetic resonance (1H MRS) and to examine whether there is any correlation between cardiac metabolites and functional New York Heart Association (NYHA) class and left ventricular function parameters obtained in echocardiography. MATERIALS AND METHODS:Fifteen patients with documented idiopathic dilated cardiomyopathy and 12 healthy volunteers were examined. The study protocol included clinical examination, 12-lead electrocardiogram, two-dimensional echocardiogram, and 1H MRS with voxel localized at interventricular septum area. The contents of total creatine (CR) ie, creatine + phosphocreatine, lipids (LIP), lactates (LAC) and their ratios (CR1A, CR2A, CR1/H20, CR2/H20, CR2/CR1, LIPA, LIP/H20, LIP/CR1, LACA, LAC/H20, LAC/CR1) were examined. RESULTS:Patients with dilated cardiomyopathy had significantly lower levels of creatine CRIA (5.04 +/- 0.88 vs 5.94 +/- 1.15, P < .02) and ratios LIP/H20 (4.34 +/- 2.3 vs 15.46 +/- 20.39, P < .04) and LIP/CR1 (24.49 +/- 21.26 vs 34.08 +/- 13.36, P < .05) compared with healthy volunteers. Significant correlations between NYHA functional class and the ratios CR2/CR1, CR2/H20 (r = 0.59, P < .038, r = 0.59, P < .02, respectively) and between %LVEF and LIP/CR1 (r = 0.64, P < .036), as well as between the duration of the disease (TCH) and LIP/CR1 (r = 0.67, P < .046) were found. CONCLUSION:A pilot study with proton spectroscopy magnetic resonance showed impairment of the cardiac metabolism in patients with idiopathic dilated cardiomyopathy. A trend to lower values of creatine and lipids, and to lower ratios of some of these metabolites was observed in the dilated cardiomyopathy group compared with healthy subjects. The results require further study.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Walecki J,Michalak MJ,Michalak E,Bilinska ZT,Ruzyllo W

doi

10.1016/s1076-6332(03)00104-1

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1187-92

issue

10

eissn

1076-6332

issn

1878-4046

journal_volume

10

pub_type

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