Abstract:
RATIONALE AND OBJECTIVES:The purpose of this study was to determine the feasibility of using transabdominal ultrasonography (US) to monitor tumor growth and response to therapy in a mouse model of orthotopic bladder carcinoma. MATERIALS AND METHODS:Human bladder carcinoma cell suspensions were injected into the bladders of 18 SCID mice, allowed to grow for 3 weeks, and monitored weekly with gray-scale US. After 23 days, five animals were treated with TNP-470, an angiogenic inhibitor, and five control animals were treated with saline solution. US images were evaluated for tumor location, size, and neovascularity. All untreated animals (n = 8) were imaged and sacrificed at 25 days. Eight of the treated animals were imaged and sacrificed after 14 days of treatment. US findings for both groups were compared with autopsy findings. RESULTS:While saline-treated tumors continued to grow, the growth of TNP-470-treated tumors was arrested within 7 days of therapy (P < .02). Tumors as small as 1.5 mm were identified prospectively with US. US volume estimates correlated well with autopsy volume measurements (r2 = 1.0, P < .0001). Although tumor neovascularity was identified in every animal, the pattern of neovascularity did not correlate with tumor volume or therapy. CONCLUSION:US can provide accurate intermediate end points for monitoring experimental intraabdominal tumor growth and response to therapy in the mouse model.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Rooks V,Beecken WD,Iordanescu I,Taylor GAdoi
10.1016/s1076-6332(01)90038-8keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
121-7issue
2eissn
1076-6332issn
1878-4046journal_volume
8pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:We analyzed multi-institutional data to determine if Step 3 performance tiers can identify radiology residents with increased risk of Core examination failure and submean performance. MATERIALS AND METHODS:We collected Step 3 scores (USMLE Step 3 or COMLEX Level 3) and American Board of Radiol...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.06.032
更新日期:2020-08-06 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.05.014
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abstract:RATIONALE AND OBJECTIVE:The aim of the study was to survey misfiled cases in a picture archiving and communication system environment at two hospitals and to demonstrate the potential usefulness of an automated patient recognition method for posteroanterior chest radiographs based on a template-matching technique desig...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.11.008
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abstract:RATIONALE AND OBJECTIVES:Although elevation of the diaphragm can be appreciated on conventional PA and lateral chest radiography, the modality is commonly viewed as inadequate to differentiate diaphragmatic paralysis from eventration. Our objective was to qualitatively and quantitatively measure the utility of chest ra...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.01.027
更新日期:2007-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate conspicuity of screen-detected cancers on two-dimensional synthetic mammography (SM) reconstructed from digital breast tomosynthesis (DBT) compared to two-dimensional full field digital mammography (FFDM). MATERIALS AND METHODS:IRB-approved retrospective review of consecutive scree...
journal_title:Academic radiology
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abstract:RATIONALE AND OBJECTIVES:Emergency department (ED) patients with acute low back pain (LBP) may present with ambiguous clinical findings that pose diagnostic challenges to exclude cauda equina syndrome (CES). As a proof of concept, we aimed to determine the efficacy of a rapid lumbar spine (LS) magnetic resonance imagin...
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abstract:RATIONALE AND OBJECTIVES:To evaluate the value of texture analysis on preoperative magnetic resonance imaging (MRI) for identifying nonfunctional pancreatic neuroendocrine neoplasms (NF-PNENs) and solid pseudopapillary neoplasms (SPNs). MATERIALS AND METHODS:This retrospective study included 119 patients who underwent...
journal_title:Academic radiology
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abstract:RATIONALE AND OBJECTIVES:Quantitative measurement provides essential information about disease progression and treatment response in patients with glioblastoma multiforme (GBM). The goal of this article is to present and validate a software pipeline for semi-automatic GBM segmentation, called AFINITI (Assisted Follow-u...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.03.026
更新日期:2012-08-01 00:00:00
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journal_title:Academic radiology
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更新日期:2017-06-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.08.011
更新日期:2013-02-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.12.004
更新日期:2006-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Great expertise is necessary to mentally compile a series of individual two-dimensional image sections into a three-dimensional (3D) composite view that can aid in differential diagnosis. The purpose of this study was to test 3D volume-rendering techniques for differentiating congenital cystic ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80108-3
更新日期:2003-03-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.016
更新日期:2017-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors compared magnetic resonance (MR) image quality obtained from 3- and 1-mm-thick sections in the depiction of the temporomandibular joint (TMJ) and its adjacent structures. MATERIALS AND METHODS:Eight TMJ specimens from four adult cadaver heads were depicted with MR imaging. Both 3- ...
journal_title:Academic radiology
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doi:10.1016/S1076-6332(99)80116-0
更新日期:1999-11-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.05.026
更新日期:2020-07-08 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80004-9
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journal_title:Academic radiology
pub_type: 杂志文章
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journal_title:Academic radiology
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journal_title:Academic radiology
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doi:10.1016/s1076-6332(03)80311-2
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.05.004
更新日期:2006-09-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.09.011
更新日期:2008-02-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80241-9
更新日期:1998-12-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.01.014
更新日期:2009-06-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.07.008
更新日期:2008-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine whether an unenhanced low-dose image acquired during automated contrast bolus timing can be used to assess hepatic steatosis. MATERIALS AND METHODS:Fifty subjects (29 male, 21 female; 26-92 years; mean body mass index (BMI; 26.9) with abdominal multiphasic computed tomography were...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.013
更新日期:2011-07-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2015-06-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.acra.2005.11.006
更新日期:2006-03-01 00:00:00
abstract::Medical eponyms are ubiquitous, numerous, and at times controversial. They are often useful for succinctly conveying complex concepts, and familiarity with eponyms is important for proper usage and appropriate communication. In this historical review, we identify 18 anatomic eponyms used to describe structures of the ...
journal_title:Academic radiology
pub_type: 传,历史文章,杂志文章,评审
doi:10.1016/j.acra.2016.01.008
更新日期:2016-06-01 00:00:00