Abstract:
RATIONALE AND OBJECTIVES:Mammographic density and parenchymal patterns have been shown to be related to the risk of developing breast cancer. Thus, computerized texture analysis of breast parenchymal patterns on mammograms may be useful in assessing breast cancer risk. MATERIALS AND METHODS:A comparative evaluation was conducted of various computer-extracted texture features of mammographic parenchymal patterns of women with BRCA1/BRCA2 gene mutations and those of women at low risk of developing breast cancer. Mammograms from 172 subjects (30 women with either the BRCA1 or BRCA2 gene mutation and 142 low-risk women) were analyzed. Computerized texture features were extracted from regions-of-interest to assess the mammographic parenchymal patterns in the images. Receiver operating characteristic analysis was used to assess the performance of these features in the task of distinguishing between the two groups of women. RESULTS:Quantitative texture analysis on digitized mammograms demonstrated that gene-mutation carriers and low-risk women have different mammographic parenchymal patterns. Gene-mutation carriers presented with parenchymal patterns that were denser, coarser, and lower in contrast than those of the low-risk group. For the gene-mutation carriers, their mammographic patterns appear to contain less high-frequency component as indicated by higher coarseness values, lower fractal dimensions, and smaller edge gradients, which yielded corresponding A(z) values of 0.79, 0.84, and 0.78, respectively, in the task of distinguishing between gene-mutation carriers and the low-risk group with the entire dataset. The contrast measure calculated from co-occurrence matrix method, which describes local image variation, yielded an A(z) value of 0.86 in distinguishing between the two groups of women. CONCLUSION:Computerized texture analysis of mammograms provides radiographic descriptors of mammographic parenchymal patterns. The computer-extracted features may be useful for identifying women at high risk for breast cancer and for monitoring the treatment of breast cancer patients.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Li H,Giger ML,Olopade OI,Margolis A,Lan L,Chinander MRdoi
10.1016/j.acra.2005.03.069keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
863-73issue
7eissn
1076-6332issn
1878-4046pii
S1076-6332(05)00347-8journal_volume
12pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:Dual-energy computed tomography (DECT) and ultrasound are both used to assess gouty arthritis. The present study was designed to compare the diagnostic accuracy of DECT and ultrasound in detecting monosodium urate (MSU) crystal deposition in various joints. MATERIALS AND METHODS:This study enr...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.010
更新日期:2015-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the usefulness of classifying degree of difficulty in abnormality detection and to determine the effect of knowing the true diagnosis when selecting subtle images for observer-performance studies. MATERIALS AND METHODS:A total of 529 posteroanterior chest images that had been used in...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80127-x
更新日期:1998-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic resonance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries - chondral defect treatment by microfractures and scaffold implantation in combinat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.05.030
更新日期:2020-06-30 00:00:00
abstract:RATIONALE AND OBJECTIVES:We evaluated the effectiveness of a fluorine-acryl-styrene-urethane-silicone (FASUS) copolymer as an antithrombogenic coating material for intravascular stents in dogs. METHODS:FASUS copolymer-coated stents were placed in the right iliac veins, and uncoated 304 stainless steel stents were plac...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80223-6
更新日期:1996-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors hypothesized that electrocardiographic triggering near end systole could minimize motion artifacts in electron-beam computed tomography (CT) of the coronary artery. MATERIALS AND METHODS:The study included 2,660 patients who underwent coronary artery calcium scanning with electron-...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/S1076-6332(03)80722-5
更新日期:2001-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Micro-computed tomography (CT) is a important tool for longitudinal imaging of tumor development. The detection and monitoring of tumors in the liver in live animals using micro-CT is challenging. We evaluated the feasibility of high-resolution micro-CT enhanced with a hepatocyte-selective cont...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.03.021
更新日期:2008-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:No single method is generally accepted for evaluating the accuracy of breast biopsy techniques before their clinical implementation. The purpose of this study was to test a new process for evaluating biopsy techniques by using it in the evaluation of a prototype three-dimensional ultrasound (US...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80331-8
更新日期:2002-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Obscure gastrointestinal bleeding (OGIB) is the bleeding from the gastrointestinal tract without definite source that persists and recurs after a negative endoscopic evaluation. The study aimed to systematically evaluate the diagnostic accuracy of computed tomography enterography on OGIB detect...
journal_title:Academic radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.acra.2017.09.001
更新日期:2018-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors used magnetic resonance (MR) imaging to investigate the correlation between T2* measurements of trabecular bone and the ultimate compressive strength of lumbar porcine vertebrae. METHODS:Five pigs that weighted 25-32 kg were sacrificed and imaged with a 1.5-T MR system. T2* of the ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80050-5
更新日期:1997-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to evaluate whether digitally photographed, computer-annotated MR images produced by clinical radiologists and printed with an inexpensive photo printer are suitable for publication. MATERIALS AND METHODS:Laser prints of 20 magnetic resonance images of the brai...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80378-1
更新日期:2002-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Presurgical assessment of fatty degeneration is important in the management of patients with rotator cuff tears. The Goutallier classification is widely accepted as a qualitative scoring system, although it is highly observer-dependent and has poor reproducibility. The objective of this study w...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.026
更新日期:2017-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Chest radiographs are recommended for prevention and detection of pneumoconiosis. In 2011, the International Labour Office (ILO) released a revision of the International Classification of Radiographs of Pneumoconioses that included a digitized standard images set. The present study compared res...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2013.11.019
更新日期:2014-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Digitizing images for use in case presentations based on hardcopy films, slides, photographs, negatives, books, and videos can present a challenging task. Scanners and digital cameras have become standard tools of the trade. Unfortunately, use of these devices to digitize multiple images in man...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00010-2
更新日期:2003-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to evaluate our preliminary experience with routine contrast-enhanced magnetic resonance angiography (CE-MRA) of the lower limb arteries in patients with end-stage renal failure. MATERIALS AND METHODS:A retrospective analysis was performed on clinical, physiologic...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.01.021
更新日期:2005-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Cellulitis is a common cause for emergency department (ED) presentation and subsequent hospital admission. Underlying fracture, osteomyelitis, or foreign body is often considered in the clinical evaluation of these patients. Accordingly, plain radiographs (XRs) of the affected extremity are oft...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.002
更新日期:2015-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to examine the effects of placing a metal stent across a bronchial orifice. MATERIALS AND METHODS:Nine pigs were used as test subjects, because the right upper lobe bronchus comes directly off the trachea in these animals. One of three types of metal stents was pl...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(99)80253-0
更新日期:1999-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Burnout is a psychological syndrome composed of emotional exhaustion, depersonalization, and sense of lack of personal accomplishment, as a result of prolonged occupational stress. The purpose of our study was to determine the prevalence of burnout among current musculoskeletal radiology fellow...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.12.024
更新日期:2017-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We evaluated the inter- and intraobserver reproducibility of measuring five morphologic parameters of the anorectum in defecography (evacuation proctography). METHODS:Measurements from 42 defecographic studies were statistically analyzed. The parameters measured during resting, squeezing, and ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80719-6
更新日期:1994-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to determine the sonographic visibility of implanted collagen-based breast biopsy marker clips in the clinic and operating room. MATERIALS AND METHODS:Female patients aged > or =18 years who presented for preoperative surgical evaluation within 4 weeks of ultrasound-g...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.10.017
更新日期:2010-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Needle biopsy is currently the only way to confirm prostate cancer. To increase prostate cancer diagnostic rate, needles are expected to be deployed at suspicious cancer locations. High-contrast magnetic resonance (MR) imaging provides a powerful tool for detecting suspicious cancerous tissues....
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.07.018
更新日期:2007-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of occult invasive disease for patients showing ductal carcinoma in situ (DCIS) only in core biopsy. MATERIALS AND METHODS:In this retrospective study, we analyzed ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.013
更新日期:2017-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Computed tomography (CT) was used to noninvasively monitor local drug pharmacokinetics from polymer implants in rat livers before and following radiofrequency ablation. MATERIALS AND METHODS:Polymer matrixes containing carboplatin (a platinum-containing chemotherapeutic agent) were implanted i...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.09.007
更新日期:2004-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Intravenous thrombolysis decision-making and obtaining of consent would be assisted by an individualized risk-benefit ratio. Deep learning (DL) models may be able to assist with this patient selection. MATERIALS AND METHODS:Clinical data regarding consecutive patients who received intravenous ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.03.015
更新日期:2020-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of the study was to investigate the optimal protocols of dual-source computed tomography (CT) angiography in aortic stent grafting in terms of image noise and radiation dose, based on an in vitro phantom study. MATERIALS AND METHODS:A series of helical CT cans were performed on a human...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.03.004
更新日期:2010-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to assess the performance of a computer-based classification system that uses gaze locations of observers to define the subspace for machine learning. MATERIALS AND METHODS:Thirty-two dental radiographs were classified by an expert viewer into four categories o...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/S1076-6332(03)80706-7
更新日期:2001-12-01 00:00:00
abstract::This paper outlines the efforts of the American College of Radiology to understand the public perception of radiologists and to effect change in that perception. Through focus groups, in-depth interviews with Capitol Hill staff members, and national telephone surveys, it was found that the public is unaware of the edu...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.02.003
更新日期:2009-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to develop and implement a respiratory-gated setup for dual-source computed tomography (CT) at high pitch to examine patients in a reproducible inspiratory phase. MATERIALS AND METHODS:Twenty-one patients underwent free-breathing respiratory-gated chest CT using a high-pitch s...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.12.018
更新日期:2016-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The American Association of Academic Chief Residents in Radiology annually surveys residency programs on a variety of issues related to residency training. The survey results allow individual programs to compare features of their programs with national averages and to gauge trends in radiology ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80288-2
更新日期:1998-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To estimate recurrence risk after surgery in nonsmall cell lung cancer (NSCLC) patients by employing tumoral and peritumoral radiomics analysis. MATERIALS AND METHODS:One-hundred twenty-four surgically treated stage IA-IIB NSCLC patients' data from 2008 to 2013 were retrospectively collected. ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.05.019
更新日期:2020-04-01 00:00:00
abstract::Technologic advances have resulted in the expansion of web-based conferencing and education. While historically video-conferencing has been used for didactic educational sessions, we present its novel use in virtual radiology read-outs in the face of the COVID-19 pandemic. Knowledge of key aspects of set-up, implement...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.04.028
更新日期:2020-06-01 00:00:00