Abstract:
RATIONALE AND OBJECTIVES:To estimate recurrence risk after surgery in nonsmall cell lung cancer (NSCLC) patients by employing tumoral and peritumoral radiomics analysis. MATERIALS AND METHODS:One-hundred twenty-four surgically treated stage IA-IIB NSCLC patients' data from 2008 to 2013 were retrospectively collected. Patient outcome was defined as local recurrence (LR), distant metastasis (DM), and (sum of LR and DM) total recurrence (TR) at follow-up. Volumetric region of interests (ROIs) were drawn for the tumor, peritumoral lung parenchyma (2 cm around the tumor) and involved lobe on CT images. Ninety-four (morphological, first-order, textural, fractal-based) radiomics features were extracted from the ROIs and datasets were created from single or combined ROIs. Predictive models were built with radiomics signature (RS) and clinicopathological data, and the area under the curve (AUC) was used to evaluate the performance. Radiomics score was calculated with the best models' feature coefficients, low- and high-risk groups of patients defined accordingly. Kaplan-Meier curves were built, and the log-rank test was used for comparison among low- and high-risk groups. Differences in recurrence risk among the two risk groups were calculated (chi-square test). RESULTS:Fifty-six patients developed TR (25 LR, 31 DM). The tumor-node-metastasis (TNM) stage recurrence predictability (AUCTR 0.680; AUCDM 0.672; AUCLR 0.580) was substantially improved when RS was added to the predictive model (AUCTR 0.760; AUCDM 0.759; AUCLR 0.750). Seventy-five percent of high-risk patients developed TR. Recurrence risk of the high-risk group was 16-fold higher than that of the low-risk group (p < 0.001). CONCLUSION:Combination of the tumoral and peritumoral RS with TNM staging system outperformed TNM staging alone in individualized recurrence risk estimation of patients with surgically treated NSCLC.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Akinci D'Antonoli T,Farchione A,Lenkowicz J,Chiappetta M,Cicchetti G,Martino A,Ottavianelli A,Manfredi R,Margaritora S,Bonomo L,Valentini V,Larici ARdoi
10.1016/j.acra.2019.05.019subject
Has Abstractpub_date
2020-04-01 00:00:00pages
497-507issue
4eissn
1076-6332issn
1878-4046pii
S1076-6332(19)30311-3journal_volume
27pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:The association between hepatic steatosis and oral 5-fluorouracil (5-FU) agents is clinically recognized but has not been systematically studied. The aim of this study was to determine the effects of 5-FU on hepatic fat content in patients undergoing oral 5-FU therapy and to compare the effects...
journal_title:Academic radiology
pub_type: 杂志文章
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journal_title:Academic radiology
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journal_title:Academic radiology
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journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80226-2
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journal_title:Academic radiology
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pub_type: 临床试验,杂志文章
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80247-9
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.05.020
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journal_title:Academic radiology
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journal_title:Academic radiology
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journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Academic radiology
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journal_title:Academic radiology
pub_type: 杂志文章
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