Abstract:
BACKGROUND:There is compelling evidence that neurochemical changes measured by proton magnetic resonance spectroscopy (1H-MRS) occur at different phases of Alzheimer's disease (AD). However, the extent to which these neurochemical changes are associated with validated AD biomarkers and/or apolipoprotein (APOE) ε4 is yet to be established. OBJECTIVE:This systematic review analyzed the available evidence on (1) neurochemical changes; and (2) the relations between brain metabolite and validated cerebrospinal fluid biomarkers, and/or APOE in AD. METHODS:PubMed, Cochrane, Scopus, and gray literature were systematically screened for studies deemed fit for the purpose of the current systematic review. RESULTS:Twenty four articles met the inclusion criteria. Decreased levels of N-acetyl aspartate (NAA), NAA/(creatine) Cr, and NAA/(myo-inositol) ml, and increased ml, ml/Cr, Cho (choline)/Cr, and ml/NAA were found in the posterior cingulate cortex/precuneus. Increased ml is associated with increased tau levels, reduced NAA/Cr is associated with increased tau. ml/Cr is negatively correlated with Aβ42, and ml/Cr is positively correlated with t-tau. NAA and glutathione levels are reduced in APOE ε4 carriers. APOE ε4 exerts no modulatory effect on NAA/Cr. There is interaction between APOE ε4, Aβ42, and ml/Cr. CONCLUSION:NAA, ml, NAA/Cr, NAA/ml and ml/Cr may be potentially useful biomarkers that may highlight functional changes in the clinical stages of AD. The combinations of ml and tau, NAA/Cr and Aβ42, and NAA/Cr and tau may support the diagnostic process of differentiating MCI/AD from healthy individuals. Large, longitudinal studies are required to clarify the effect of APOE ε4 on brain metabolites.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Piersson AD,Mohamad M,Rajab F,Suppiah Sdoi
10.1016/j.acra.2020.06.006subject
Has Abstractpub_date
2020-07-07 00:00:00eissn
1076-6332issn
1878-4046pii
S1076-6332(20)30356-1pub_type
杂志文章,评审abstract:RATIONALE AND OBJECTIVES:We systematically characterized the information provided by chest radiography reports on a nationally representative sample of 822 elderly patients hospitalized in 297 acute-care hospitals in five states who had an admission diagnosis of congestive heart failure, acute myocardial infarction, or...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80407-7
更新日期:1996-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Digitizing images for use in case presentations based on hardcopy films, slides, photographs, negatives, books, and videos can present a challenging task. Scanners and digital cameras have become standard tools of the trade. Unfortunately, use of these devices to digitize multiple images in man...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00010-2
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To investigate the correlation between dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) parameters and angiogenesis and to explore prospectively the feasibility of using DSC-MRI to differentiate malignant from benign soft tissue tumors (STTs) in limbs. METHODS:This prospective study inclu...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.04.023
更新日期:2020-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Osteoarthritis (OA) is a common disease, and early diagnosis is essential for preventing further cartilage destruction and decreasing severe complications. Ultrasound biomicroscopy (UBM) is sensitive for detecting minute lesions in tissue because of its higher resolution, but its B-mode charact...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.09.011
更新日期:2011-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morpho...
journal_title:Academic radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.acra.2009.07.022
更新日期:2010-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to determine whether uterine leiomyoma can be distinguished from uterine leiomyosarcoma on ultrasound (US), computed tomography (CT), and/or magnetic resonance imaging (MRI) without diffusion-weighted imaging. MATERIALS AND METHODS:Institutional review board approval was obtai...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.06.004
更新日期:2016-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the performance of dual-energy computed tomography (DECT) equipped with the new tin filter technology to classify phantom renal lesions as cysts or enhancing masses. MATERIALS AND METHODS:Forty spherical lesion proxies ranging in diameter from 6 to 27 mm were filled with either disti...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.11.007
更新日期:2010-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We examined whether high-resolution computed tomography (HRCT) would detect and quantify induced airway changes in asthmatic volunteers. METHODS:We performed pulmonary function tests and HRCT on eight asthmatic adults and two nonasthmatic control adults under three conditions: baseline, after ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80671-3
更新日期:1996-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The study aimed to determine whether the addition of the Fleischner Society guidelines to chest computed tomography (CT) reports identifying incidental pulmonary nodules affects follow-up care. PATIENTS AND METHODS:Beginning in 2008, a template containing the Fleischner Society guidelines was ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.08.026
更新日期:2017-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Q-space analysis using high b-value diffusion-weighted magnetic resonance (MR) data provides information on tissue microstructure in contrast to conventional MR imaging (MRI) based on low b-value diffusion-weighted imaging (DWI). The purpose of this study was to evaluate the use of mean displac...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.005
更新日期:2011-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study was performed to determine physical characteristics of areas on chest radiographs that are suspicious but not definitive for the presence of a pulmonary nodule and the characteristics of areas that contain an obvious nodule. MATERIALS AND METHODS:Two groups of patients were identifi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80297-3
更新日期:1998-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to evaluate our preliminary experience with routine contrast-enhanced magnetic resonance angiography (CE-MRA) of the lower limb arteries in patients with end-stage renal failure. MATERIALS AND METHODS:A retrospective analysis was performed on clinical, physiologic...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.01.021
更新日期:2005-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to evaluate whether digitally photographed, computer-annotated MR images produced by clinical radiologists and printed with an inexpensive photo printer are suitable for publication. MATERIALS AND METHODS:Laser prints of 20 magnetic resonance images of the brai...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80378-1
更新日期:2002-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the reproducibility of Modified Response Evaluation Criteria in Solid Tumors (mRECIST) for hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE) using multiphasic computed tomography. MATERIALS AND METHODS:The institutional review board approved this retrospec...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.02.013
更新日期:2018-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Evidence is inconsistent about whether radiologists' interpretive performance on a screening mammography test set reflects their performance in clinical practice. This study aimed to estimate the correlation between test set and clinical performance and determine if the correlation is influence...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.016
更新日期:2017-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:We sought to establish medical students' perspectives of a set of curriculum topics for radiology teaching. MATERIALS AND METHODS:A multicenter study was conducted in New Zealand. A modified Delphi method was adopted. Students enrolled in two New Zealand Universities received a questionnaire. E...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acra.2006.02.034
更新日期:2006-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the value of MRI-based features and texture analysis (TA) in the differential diagnosis between ovarian thecomas/fibrothecomas (OTCA/f-TCAs) and uterine fibroids in the adnexal area (UF-iaas). MATERIALS AND METHODS:This retrospective study included 16 OTCA/f-TCA and 37 UF-iaa pa...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.12.025
更新日期:2020-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diffusion tensor tractography (DTT) for neural fibers of the head-and-neck region at 3T has not been reported. The purpose of this study was to evaluate the feasibility of using DTT for visualizing neural fibers in the head-and-neck region at 3T and to explore the use of this method in patients...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.01.019
更新日期:2009-07-01 00:00:00
abstract::Rapid growth in the amount of data that is electronically recorded as part of routine clinical operations has generated great interest in the use of Big Data methodologies to address clinical and research questions. These methods can efficiently analyze and deliver insights from high-volume, high-variety, and high-gro...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2015.10.004
更新日期:2016-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to determine the acquisition and interpretation times of screen-film mammography and soft-copy digital mammography in a diagnostic mammography center. MATERIALS AND METHODS:The study was conducted in three phases for patients presenting for clinical diagnostic wor...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.04.018
更新日期:2010-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To assess the feasibility of 70-kVp high-pitch non-ECG-gated thoracic aortic computed tomography angiography (CTA) with 40-mL contrast agent compared to 100-kVp standard-pitch CTA with 60-mL contrast agent. MATERIALS AND METHODS:Sixty-seven patients (51 men and 16 women; mean age, 55 ± 14 year...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.03.007
更新日期:2015-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We propose a novel segmentation-based interpolation method to reduce the metal artifacts caused by surgical aneurysm clips. MATERIALS AND METHODS:Our method consists of five steps: coarse image reconstruction, metallic object segmentation, forward-projection, projection interpolation, and fina...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.12.015
更新日期:2007-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate if incidental abdominopelvic calcified atherosclerosis (ACA) in patients under 50 years of age correlates with cardiovascular disease (CVD) risk factors. Most studies evaluating calcific atherosclerosis and associated increased risk of CVD have concentrated on middle age and older p...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.10.013
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Coronary computed tomographic angiography (CTA) is a valuable tool for assessing coronary artery disease (CAD). Although statin use is widely recommended for persons with diabetes older than age 40, little is known about the presence and severity of CAD in younger patients with diabetes mellitus (DM). We evalua...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.03.013
更新日期:2012-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors developed a computerized method for delineating the costophrenic angles in digital posteroanterior chest radiographs to derive quantitative information that allows for detection of abnormal blunting of the costophrenic angle. MATERIALS AND METHODS:An automated lung-segmentation sch...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80151-7
更新日期:1998-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:It was hypothesized that perfusion computed tomography (CT), blood flow (BF), blood volume (BV), and vascular permeability surface area (PS) product parameters would be predictive of therapeutic anticancer agent uptake in pancreatic cancer, facilitating image-guided interpretation of human trea...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.12.014
更新日期:2015-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diffusion-weighted imaging (DWI) is a noninvasive imaging technique that reflects the diffusion movement of water molecules through apparent diffusion coefficient (ADC) values. The role of DWI in predicting the histological response to neoadjuvant chemotherapy in osteosarcoma is being increasin...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2020.11.013
更新日期:2020-12-29 00:00:00
abstract:RATIONALE AND OBJECTIVES:We report social media (SoMe) utilization trends at an academic radiology department, highlighting differences between trainees and faculty and between Baby Boomers versus Generation X and Millennials. MATERIALS AND METHODS:An anonymous online survey regarding SoMe utilization and SoMe-based e...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.08.012
更新日期:2018-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Today, the exchange of medical images and clinical information is well defined by the digital imaging and communications in medicine (DICOM) and Health Level Seven (ie, HL7) standards. The interoperability among information systems is specified by the integration profiles of IHE (Integrating the...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.11.015
更新日期:2005-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Malignancy provokes regional changes to vessel shape. Characteristic vessel tortuosity abnormalities appear early during tumor development, affect initially healthy vessels, spread beyond the confines of tumor margins, and do not simply mirror tissue perfusion. The ability to detect and quantif...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.05.027
更新日期:2005-10-01 00:00:00