Abstract:
:The role of positron emission tomography (PET) during the past decade has evolved rapidly from that of a pure research tool to a methodology of enormous clinical potential. (18)F-fluorodeoxyglucose (FDG)-PET is currently the most widely used probe in the diagnosis, staging, assessment of tumor response to treatment, and radiation therapy planning because metabolic changes generally precede the more conventionally measured parameter of change in tumor size. Data accumulated rapidly during the last decade, thus validating the efficacy of FDG imaging and many other tracers in a wide variety of malignant tumors with sensitivities and specificities often in the high 90 percentile range. As a result, PET/computed tomography (CT) had a significant impact on the management of patients because it obviated the need for further evaluation, guided further diagnostic procedures, and assisted in planning therapy for a considerable number of patients. On the other hand, the progress in radiation therapy technology has been enormous during the last two decades, now offering the possibility to plan highly conformal radiation dose distributions through the use of sophisticated beam targeting techniques such as intensity-modulated radiation therapy (IMRT) using tomotherapy, volumetric modulated arc therapy, and many other promising technologies for sculpted three-dimensional (3D) dose distribution. The foundation of molecular imaging-guided radiation therapy lies in the use of advanced imaging technology for improved definition of tumor target volumes, thus relating the absorbed dose information to image-based patient representations. This review documents technological advancements in the field concentrating on the conceptual role of molecular PET/CT imaging in radiation therapy treatment planning and related image processing issues with special emphasis on segmentation of medical images for the purpose of defining target volumes. There is still much more work to be done and many of the techniques reviewed are themselves not yet widely implemented in clinical settings.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Zaidi H,Vees H,Wissmeyer Mdoi
10.1016/j.acra.2009.02.014subject
Has Abstractpub_date
2009-09-01 00:00:00pages
1108-33issue
9eissn
1076-6332issn
1878-4046pii
S1076-6332(09)00144-5journal_volume
16pub_type
杂志文章,评审abstract:RATIONALE AND OBJECTIVES:To assess the diagnostic performance of magnetic resonance imaging (MRI) for targeting prostate cancer in patients with previous negative biopsies and elevated prostate-specific antigen (PSA) levels. MATERIALS AND METHODS:Pubmed, Scopus, and Cochrane Library databases were searched to identify...
journal_title:Academic radiology
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.acra.2014.01.004
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The Accreditation Council on Graduate Medical Education (ACGME) through its Outcome Project requires training programs in all medical specialties to integrate six general competencies into residency training: patient care, medical knowledge, professionalism, interpersonal and communication skil...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.12.016
更新日期:2011-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Ultrasonography (US) is becoming popular for the assessment of adiposity, but no one has studied this tool in the light of its potential limitations. Our purpose was to investigate the impact of technical conditions on the evaluation of abdominal fat by US. MATERIALS AND METHODS:Forty-five hea...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2013.07.009
更新日期:2013-10-01 00:00:00
abstract::Despite the widespread belief that advanced imaging should be very helpful in guiding oncology treatment decision and improving efficiency and success rates in treatment clinical trials, its acceptance has been slow. Part of this is likely attributable to gaps in study design and statistical methodology for these imag...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2017.03.002
更新日期:2017-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The capability of wavelet transforms to separate signals into frequency bands is the basis for its use in image compression and storage, data management and transmission, and, recently, extraction of latent images of tissue components from noisy medical images. Analysis of temporal variations o...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.06.018
更新日期:2007-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to investigate the subjective similarity for pairs of images with various abnormal patterns of diffuse interstitial lung disease on thin-section computed tomography by experienced radiologists to explore a basis for selecting similar images to assist radiologists' inte...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.10.016
更新日期:2009-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Abdominal radiologists actively participated and provided subspecialty radiologic expertise in a multidisciplinary gastrointestinal cancer clinic that served a tertiary referral center. The purpose of this study was to evaluate the feasibility and nonradiologists' opinions of this new approach ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80564-3
更新日期:1998-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Surgical repair of an isolated orbital fracture requires anatomically accurate implant shape and placement. We describe a three-dimensional (3D) printing technique to customize the shape of commercially available absorbable implants. MATERIALS AND METHODS:We reviewed our early experience with ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.06.023
更新日期:2020-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:(23)Na magnetic resonance imaging is a promising technique for the noninvasive imaging of renal function. Past investigations of the renal corticomedullary [(23)Na] gradient have relied on imaging only in the coronal plane and on cumbersome calculations of [(23)Na], which require the use of ext...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.10.009
更新日期:2013-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The objective of this study was to develop and quantitatively evaluate a radiology-pathology fusion method for spatially mapping tissue regions corresponding to different chemoradiation therapy-related effects from surgically excised whole-mount rectal cancer histopathology onto preoperative ma...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.12.006
更新日期:2018-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine the differences in the psychosocial effects and future mammography screening behavior between women who had an abnormal mammogram followed either by percutaneous or open surgical breast biopsy or cyst aspiration, or by short-term follow-up mammography to provide insight to radiolog...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00382-9
更新日期:2003-11-01 00:00:00
abstract::Radiology practice will be altered by the coming of artificial intelligence, and the process of learning in radiology will be similarly affected. In the short term, radiologists will need to understand the first wave of artificially intelligent tools, how they can help them improve their practice, and be able to effec...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.03.007
更新日期:2018-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To prospectively analyze the correlation between parameters of liver perfusion from technetium99m-macroaggregates of albumin (99mTc-MAA) single photon emission computed tomography (SPECT) with those obtained from dynamic CT perfusion in patients with primary or metastatic liver malignancy. MAT...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.12.015
更新日期:2012-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The increasing use of computed tomography (CT) has been accompanied by rising concerns over potential radiation-related health risks, especially cancer, and a need to minimize such risks. MATERIALS AND METHODS:We conducted 2186 low-dose helical chest CT scans among 1235 nuclear weapons workers...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.09.015
更新日期:2012-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the effect of a newly developed computer-aided diagnosis (CAD) system on reader interpretation of breast lesions in automated three-dimensional (3D) breast ultrasound. MATERIALS AND METHODS:A CAD system was developed to differentiate malignant lesions from benign lesions includi...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acra.2013.07.013
更新日期:2013-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the correlations of tracheal volume and collapsibility on inspiratory and end-expiratory computed tomography (CT) with lung volume and with lung function in smokers. MATERIALS AND METHODS:The institutional review board approved this study at each institution. 85 smokers (mean age 6...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.11.005
更新日期:2011-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Chest radiographs are recommended for prevention and detection of pneumoconiosis. In 2011, the International Labour Office (ILO) released a revision of the International Classification of Radiographs of Pneumoconioses that included a digitized standard images set. The present study compared res...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2013.11.019
更新日期:2014-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Extraintestinal abnormalities visible without contrast material on abdominal radiographs are reported less frequently when contrast examinations are performed. Gaze dwell time was used to determine whether this difference is due to failure by observers to scan plain-film regions of contrast stu...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80271-6
更新日期:1996-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Severe calcifications of the coronary arteries are still a major challenge in coronary computed tomography (CT) angiography (CCTA). Subtraction CCTA using a 320-detector row CT scanner has recently been introduced for patients with severe calcifications. However, the conventional subtraction CC...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.04.012
更新日期:2016-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:In percutaneous ethanol injection therapy, uncontrolled spread of ethanol sometimes causes complications. This study tested the accuracy of ultrasonography in showing the spread of ethanol during injection in normal postmortem pig livers. METHODS:Methylene blue-stained 96% (vol) ethanol (0.5-2...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80778-0
更新日期:1994-09-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to perform a quantitative assessment of the prostate anatomy with a focus on the relation of prostatic urethral anatomic variation to urinary symptoms. METHODS:This retrospective study involved patients undergoing magnetic resonance imaging for prostate cancer who were also asses...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.03.017
更新日期:2020-04-16 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the value of texture analysis on preoperative magnetic resonance imaging (MRI) for identifying nonfunctional pancreatic neuroendocrine neoplasms (NF-PNENs) and solid pseudopapillary neoplasms (SPNs). MATERIALS AND METHODS:This retrospective study included 119 patients who underwent...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.07.012
更新日期:2020-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:In vivo tracking cells using gadolinium-based contrast agents have the important advantage of providing a positive contrast on T1-weighted images, which is less likely to be confused with artifacts because of postoperative local signal voids such as metal, hemorrhage, or air. The aim of this st...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.03.016
更新日期:2009-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:An automated method for identification and segmentation of acute/subacute ischemic stroke, using the inherent bi-fold symmetry in brain images, is presented. An accurate and automated method for localization of acute ischemic stroke could provide physicians with a mechanism for early detection ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.03.013
更新日期:2008-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The goal of this study is to demonstrate how the teaching of radiology physics can be enhanced with the use of interactive scientific notebook software. METHODS:We used the scientific notebook software known as Project Jupyter, which is free, open-source, and available for the Macintosh, Windo...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.11.024
更新日期:2018-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A critical element in determining biologic behavior of pulmonary nodules is volume and temporal volume change. We evaluate variability in nodule volume among readers and measuring methods. MATERIALS AND METHODS:55 small (<2 cm) lung nodules were measured in long- and short-axis dimensions inde...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.04.009
更新日期:2005-08-01 00:00:00
abstract::In medicine, an eponym is a word-typically referring to an anatomic structure, disease, or syndrome-that is derived from a person's name. Medical eponyms are ubiquitous and numerous. They are also at times controversial. Eponyms reflect medicine's rich and colorful history and can be useful for concisely conveying com...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2016.04.011
更新日期:2016-10-01 00:00:00
abstract::Response Evaluation Criteria in Solid Tumors (RECIST) is a standardized methodology for determining therapeutic response to anticancer therapy using changes in lesion appearance on imaging studies. Many radiologists are now using RECIST in their routine clinical workflow, as part of consultative arrangements, or withi...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2015.01.015
更新日期:2015-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:I developed a volume estimation technique for the crescentic volume of the right ventricle (RV) of the heart. A geometric model was desired to avoid the lengthy data collection and reduction required by Simpson's rule. METHODS:An ellipsoidal shell model was developed that requires only simple ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(12)80006-7
更新日期:1994-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Burnout is a psychological syndrome composed of emotional exhaustion, depersonalization, and sense of lack of personal accomplishment, as a result of prolonged occupational stress. The purpose of our study was to determine the prevalence of burnout among current musculoskeletal radiology fellow...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.12.024
更新日期:2017-06-01 00:00:00