Abstract：
:Despite the widespread belief that advanced imaging should be very helpful in guiding oncology treatment decision and improving efficiency and success rates in treatment clinical trials, its acceptance has been slow. Part of this is likely attributable to gaps in study design and statistical methodology for these imaging studies. Also, results supporting the performance of the imaging in these roles have largely been insufficient to justify their use within the design of a clinical trial or in treatment decision making. Statistically significant correlations between the imaging results and clinical outcomes are often incorrectly taken as evidence of adequate performance. Assessments of whether the imaging can outperform standard techniques or meaningfully supplement them are also frequently neglected. This paper provides guidance on study designs and statistical analyses for evaluating the performance of advanced imaging in the various roles in treatment decision guidance and clinical trial conduct. Relevant methodology from the imaging literature is reviewed; gaps in the literature are addressed using related concepts from the more extensive genomic and in vitro biomarker literature.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Huang EP,Lin FI,Shankar LKdoi
10.1016/j.acra.2017.03.002subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1036-1049issue
8eissn
1076-6332issn
1878-4046pii
S1076-6332(17)30120-4journal_volume
24pub_type
杂志文章,评审abstract：RATIONALE AND OBJECTIVES:Skeletal muscle mass measurement is the most important element for diagnosing sarcopenia. MRI has an excellent soft-tissue contrast, which can non-invasively assess abdominal skeletal muscle area (SMA) as well as CT. This study aimed to assess the validity and reliability of abdominal SMA measu...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.09.013
更新日期：2020-10-28 00:00:00
abstract：RATIONALE AND OBJECTIVES:A national needs assessment of radiology program directors was performed to characterize grand rounds (GR) programs, assess the perceived educational value of GR programs, and determine the impact of the recent economic downturn on GR. MATERIALS AND METHODS:A 28-question survey was developed q...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2011.08.015
更新日期：2011-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:In percutaneous ethanol injection therapy, uncontrolled spread of ethanol sometimes causes complications. This study tested the accuracy of ultrasonography in showing the spread of ethanol during injection in normal postmortem pig livers. METHODS:Methylene blue-stained 96% (vol) ethanol (0.5-2...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(05)80778-0
更新日期：1994-09-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to evaluate the American College of Radiology (ACR) accreditation phantom for assessing image quality in digital mammography. MATERIALS AND METHODS:Digital images were obtained of an ACR accreditation phantom at varying mAs (constant kVp) and varying kVp (constant...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(03)80345-8
更新日期：2002-07-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To estimate the gain in signal-to-noise ratio (SNR) in first-pass contrast-enhanced (CE) abdominal magnetic resonance angiography (MRA) at 3.0 T compared with 1.5 T. MATERIALS AND METHODS:Three protocols were simulated using six contrast agents: gadopentetate dimeglumine (Magnevist, Berlex, Wa...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2007.03.007
更新日期：2007-07-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Estimation of regional lung function parameters from hyperpolarized gas magnetic resonance images can be very sensitive to presence of noise. Clustering pixels and averaging over the resulting groups is an effective method for reducing the effects of noise in these images, commonly performed by...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2008.03.002
更新日期：2008-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The aim of this study was to evaluate the intratumoral residence time of microbubbles (MBs) targeted to alpha(v)beta(3) integrin expressed in the endothelial cells of mice during the process of tumor angiogenesis. MATERIALS AND METHODS:For the preparation of MBs, decafluorobutane gas was sonic...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2009.07.017
更新日期：2010-01-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The addition of digital breast tomosynthesis (DBT) to digital screening mammography (DM) has been shown to decrease recall rates and improve cancer detection rates, but there is a lack of data regarding the impact of DBT on rates of short-term follow-up. We assessed possible changes in performa...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2016.10.001
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:There is compelling evidence that neurochemical changes measured by proton magnetic resonance spectroscopy (1H-MRS) occur at different phases of Alzheimer's disease (AD). However, the extent to which these neurochemical changes are associated with validated AD biomarkers and/or apolipoprotein (APOE) ε4 is ye...
journal_title：Academic radiology
pub_type： 杂志文章,评审
doi：10.1016/j.acra.2020.06.006
更新日期：2020-07-07 00:00:00
abstract：RATIONALE AND OBJECTIVES:To evaluate the sensitivity of high-resolution breast-specific gamma imaging (BSGI) for the detection of ductal carcinoma in situ (DCIS) based on histopathology and to compare the sensitivity of BSGI with mammography and magnetic resonance imaging (MRI) for the detection of DCIS. MATERIALS AND...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2007.04.004
更新日期：2007-08-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Total kidney volume is an important biomarker for the evaluation of autosomal dominant polycystic kidney disease progression. In this study, we present a novel approach for automated segmentation of polycystic kidneys from non-contrast-enhanced computed tomography (CT) images. MATERIALS AND ME...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2017.11.015
更新日期：2018-07-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Evidence is inconsistent about whether radiologists' interpretive performance on a screening mammography test set reflects their performance in clinical practice. This study aimed to estimate the correlation between test set and clinical performance and determine if the correlation is influence...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2017.03.016
更新日期：2017-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We analyzed multi-institutional data to determine if Step 3 performance tiers can identify radiology residents with increased risk of Core examination failure and submean performance. MATERIALS AND METHODS:We collected Step 3 scores (USMLE Step 3 or COMLEX Level 3) and American Board of Radiol...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.06.032
更新日期：2020-08-06 00:00:00
abstract：RATIONALE AND OBJECTIVES:Morphologic changes of the human brain during healthy aging provide useful reference knowledge for age-related brain disorders. The aim of this study was to explore age-related global and regional morphological changes of healthy adult brains. MATERIALS AND METHODS:T1-weighted magnetic resonan...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2012.03.006
更新日期：2012-07-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to determine the electronic requirements for supporting evidence-based radiology in today's medical environment. MATERIALS AND METHODS:A software engineering technique, use case modeling, was performed for several clinical settings to determine the use of imaging ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(03)80311-2
更新日期：2002-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We evaluated the inter- and intraobserver reproducibility of measuring five morphologic parameters of the anorectum in defecography (evacuation proctography). METHODS:Measurements from 42 defecographic studies were statistically analyzed. The parameters measured during resting, squeezing, and ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(05)80719-6
更新日期：1994-11-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Electron beam angiography is a minimally invasive imaging technique. Adequate vascular opacification throughout the study remains a critical issue for image quality. We hypothesized that vascular image opacification and uniformity of vascular enhancement between slices can be improved using mul...
journal_title：Academic radiology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.acra.2005.09.087
更新日期：2006-02-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To describe the application of time maximum intensity projection CTA (t-MIP CTA) in acute ischemic stroke and compare t-MIP CTA and single-phase CTA (sCTA) in assessing collateral circulation and predicting prognosis. MATERIALS AND METHODS:Twenty-nine acute ischemic stroke patients who underwe...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2019.06.013
更新日期：2020-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We investigated the influence of muscular activity and regional body temperature changes on the accumulation of intravenously (i.v.) administered, dextran-coated superparamagnetic iron oxide (SPIO) particles in the lymph nodes of rats. METHODS:Four groups of rats (N = 21) were used. Five rats ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(96)80193-0
更新日期：1996-08-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:This study was undertaken to develop a standard that can be used to assess new high-resolution collateral zone imaging methods. MATERIALS AND METHODS:The authors performed ex vivo helical CT in seven pig hearts after microsphere studies of blood flow and coronary angiography. They compared the...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(97)80139-0
更新日期：1997-10-01 00:00:00
abstract：:This review article presents the current evidence of the importance of integrating radiology and anatomy in medical education in the UK, a recommendation by a number of key anatomy, education, and radiology organizations. Current evidence highlights that on average only 5% of total teaching time in medical education i...
journal_title：Academic radiology
pub_type： 杂志文章,评审
doi：10.1016/j.acra.2015.12.010
更新日期：2016-04-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Tumor grading of nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) determines the choice of clinical treatment and management. The pathological grade of pancreatic neuroendocrine tumors is usually assessed on postoperative specimens. The goal of our study is to establish a tumor grade (...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2020.01.002
更新日期：2020-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The authors evaluated changes of lung attenuation in pigs, with special attention to the mosaic pattern of low attenuation, at thin-section computed tomography (CT) after obstruction of the proximal pulmonary artery with a detachable balloon. MATERIALS AND METHODS:In seven pigs, nine sites of ...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(98)80241-9
更新日期：1998-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Rotator cuff disorders are prevalent and can cause pain and reduced range of motion and strength. Accurate, noninvasive diagnosis of rotator cuff disorders is therefore important. In this work, we study the relationship between several three-dimensional (3D) shape measurements of the supraspina...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2007.06.014
更新日期：2007-10-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The aim of this study was to determine the optimal arterial phase delay for computed tomography imaging of hepatocellular carcinoma (HCC) before and after transarterial chemoembolization (TACE) using a low iodine dose protocol. MATERIALS AND METHODS:A total of 39 patients with known HCC were i...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2015.08.021
更新日期：2015-12-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:We studied preparatory strategies for high-resolution human eye in vivo imaging with commercially available magnets and coils. MATERIALS AND METHODS:We imaged normal volunteers on 1.5T systems by Philips, GE, and Siemens, using commercial approximately 9 cm temporomandibular joint receive coil...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2005.10.023
更新日期：2006-03-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The development of curriculum guidelines for radiology residency has been found to be favored by 80% of program directors (PDs) nationwide. I surveyed PDs to develop a consensus of opinion concerning minimum training requirements in the subspecialty rotations. METHODS:A survey developed by mem...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/s1076-6332(96)80013-4
更新日期：1996-06-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The aim of this study was to assess similarities and differences between methods of performance comparisons under binary (yes or no) and receiver-operating characteristic (ROC)-type pseudocontinuous (0-100) rating data ascertained during an observer performance study of interpretation of full-f...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2009.12.012
更新日期：2010-05-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:To quantify the relationship between dose of contrast administered and contrast kinetics of malignant breast lesions. MATERIALS AND METHODS:A total of 108 patients with 120 malignant lesions were selected for an institutional review board-approved review. Dynamic magnetic resonance protocol: o...
journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2009.06.015
更新日期：2010-01-01 00:00:00
abstract：:The National Cancer Institute organized a workshop entitled "Image Archive Management" that was presented on August 28 and 29, 2000, at the Natcher Conference Center on the National Institutes of Health (NIH) campus. The purpose of this workshop was to solicit expert input for the planned development of an archival sy...
journal_title：Academic radiology
pub_type：
doi：10.1016/S1076-6332(03)80699-2
更新日期：2001-07-01 00:00:00
