Abstract:
RATIONALE AND OBJECTIVES:The capability of wavelet transforms to separate signals into frequency bands is the basis for its use in image compression and storage, data management and transmission, and, recently, extraction of latent images of tissue components from noisy medical images. Analysis of temporal variations of radiofrequency backscatter of intravascular ultrasound with one-dimensional wavelets can detect lipid-laden plaque in coronary arteries with a sensitivity and specificity of >80%. In this study we evaluate the capability of a novel, 3-dimensional isotropic wavelet analysis to perform high resolution, non-directionally biased, statistically reliable, non-invasive discrimination between components of human coronary atherosclerotic plaques in micro-CT. MATERIALS AND METHODS:Coronary artery segments (5-15 mm) were excised at necropsy from 18 individuals with advanced coronary atherosclerosis. Specimens were imaged using a GE Locus SP ex vivo micro-CT scanner and processed for histological correlation (833 sections). The isotropic wavelet constructs were applied to the entire volume of CT data of each arterial segment to distinguish tissue textures of varying scales and intensities. Voxels were classified and plaque characterization achieved by comparing the relative magnitudes of these wavelet constituents to that of several reference plaque tissue components. RESULTS:Processing of micro-CT images via these isotropic wavelet algorithms permitted 3-D, color-coded, high resolution, digital discrimination between lumen, calcific deposits, lipid-rich deposits, and fibromuscular tissue providing detail not possible with conventional thresholding based on Hounsfield intensity units. Using the isotropic wavelets (with histology as the gold standard), lipid-rich pools approaching the size of the filter for the isotropic wavelet algorithm (0.25 mm [250 microns] in length) were identified with 81% sensitivity and 86% specificity. Calcific deposits, fibromuscular tissue, and lumen equal to or larger than the wavelet filter size were detected without error (100% sensitivity and specificity). CONCLUSION:Isotropic wavelet analysis permits high resolution, multi-dimensional identification of coronary atherosclerotic plaque components in micro-CT with sensitivity and specificity similar to that achieved with data obtained invasively (from IVUS in vivo) using one-dimensional wavelets. Further studies are necessary to test the applicability of this technology to clinical, multi-detector scanners.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Gertz SD,Bodmann BG,Vela D,Papadakis M,Aboshady I,Cherukuri P,Alexander S,Kouri DJ,Baid S,Gittens AA,Gladish GW,Conyers JL,Cody DD,Gavish L,Mazraeshahi RM,Wilner WT,Frazier L,Madjid M,Zarrabi A,Lukovenkov S,Ahmeddoi
10.1016/j.acra.2007.06.018subject
Has Abstractpub_date
2007-12-01 00:00:00pages
1509-19issue
12eissn
1076-6332issn
1878-4046pii
S1076-6332(07)00341-8journal_volume
14pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:Our purpose in this study was to develop an automated computer-aided volumetry (CAV) scheme for quantifying pneumothorax in multidetector computed tomography (MDCT) images for pediatric patients and to investigate the imaging parameters that may affect its accuracy. MATERIALS AND METHODS:Fifty...
journal_title:Academic radiology
pub_type: 杂志文章
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abstract:RATIONALE AND OBJECTIVES:A novel ventilation imaging method based on four-dimensional (4D) computed tomography (CT) has been applied to the field of radiation oncology. Understanding its reproducibility is a prerequisite for clinical applications. The purpose of this study was to quantify the reproducibility of 4D CT v...
journal_title:Academic radiology
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abstract:RATIONALE AND OBJECTIVES:We investigated the influence of muscular activity and regional body temperature changes on the accumulation of intravenously (i.v.) administered, dextran-coated superparamagnetic iron oxide (SPIO) particles in the lymph nodes of rats. METHODS:Four groups of rats (N = 21) were used. Five rats ...
journal_title:Academic radiology
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abstract::This case study chronicles the impact of Hurricane Katrina on the Department of Radiology at the Louisiana State University School of Medicine in New Orleans and the department's subsequent efforts to recover and re-dedicate itself to providing quality patient care and resident education. Hurricane Katrina damaged the...
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pub_type: 临床试验,杂志文章
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