Estimation of volumes of distribution and intratumoral ethanol concentrations by computed tomography scanning after percutaneous ethanol injection.

Abstract:

RATIONALE AND OBJECTIVES:We developed a technique for estimating the volumes of distribution and intratumoral ethanol concentrations using computed tomography (CT) scanning in patients undergoing percutaneous ethanol injection (PEI) treatment of malignant hepatic tumors. METHODS:A phantom containing anhydrous ethanol diluted with deionized distilled water to concentrations of 0-100% ethanol was scanned by CT. Thirty-seven treatment sessions were performed on eight patients with malignant hepatic tumors undergoing PEI under CT guidance. The patients were scanned pre- and post-PEI, and a region of interest containing the treated hepatic tissue was selected for pixels between -250 and 15 Hounsfield units (H). The mean density of the pixels in this range was computed and the concentration of ethanol estimated. Volumes of distribution of ethanol and intratumoral concentration were then correlated with volume of ethanol injected during PEI. The ratios of volumes of distribution of ethanol to ethanol injected (adjusted in-range [IR]/volume injected) were compared for responders (n = 4) and nonresponders (n = 4). RESULTS:CT numbers in the phantom scaled linearly with ethanol concentration; 100% ethanol measured -234 H. On CT scans after PEI, the volume of distribution of ethanol correlated positively with the volume injected. Calculated intratumoral ethanol concentrations ranged from 4% to 31%. The adjusted IR/volume injected was significantly higher for responders than nonresponders (p < .5). CONCLUSION:CT density data can be used to estimate volume of ethanol distribution in tissue; a larger relative intratumoral distribution of alcohol appears to correlate with a favorable response to PEI. However, CT measurement of intratumoral ethanol concentrations may require more complex computational techniques.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Alexander DG,Unger EC,Seeger SJ,Karmann S,Krupinski EA

doi

10.1016/S1076-6332(96)80333-3

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

49-56

issue

1

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(96)80333-3

journal_volume

3

pub_type

杂志文章
  • MRI-based delta-radiomics are predictive of pathological complete response after neoadjuvant chemoradiotherapy in locally advanced rectal cancer.

    abstract:RATIONALE AND OBJECTIVES:To investigate the capability of delta-radiomics to predict pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS:This retrospective study enrolled 165 consecutive patients with LARC (traini...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2020.10.026

    authors: Wan L,Peng W,Zou S,Ye F,Geng Y,Ouyang H,Zhao X,Zhang H

    更新日期:2020-11-11 00:00:00

  • Data analysis for detection and localization of multiple abnormalities with application to mammography.

    abstract:RATIONALE AND OBJECTIVES:In assessing diagnostic accuracy it is often essential to determine the reader's ability both to detect and to correctly locate multiple abnormalities per patient. The authors developed a new approach for the detection and localization of multiple abnormalities and compared it with other approa...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(00)80324-4

    authors: Obuchowski NA,Lieber ML,Powell KA

    更新日期:2000-07-01 00:00:00

  • ABR Core examination preparation: results of a survey of fourth-year radiology residents who took the 2013 examination.

    abstract:RATIONALE AND OBJECTIVES:A survey was administered to fourth-year radiology residents after receiving their results from the first American Board of Radiology (ABR) Core examination in 2013. The purpose was to gather information regarding resources and study strategies to share with program directors and future residen...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2014.07.026

    authors: Shetty AS,Grajo JR,Decker S,Heitkamp DE,DeStigter KK,Mezwa DG,Deitte L

    更新日期:2015-01-01 00:00:00

  • Do telephone call interruptions have an impact on radiology resident diagnostic accuracy?

    abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to measure the effect of distractions, in the form of telephone call interruptions, on radiology resident diagnostic accuracy. MATERIALS AND METHODS:Radiology resident discrepancy reports and reading room telephone logs at an academic tertiary care pediatric hospi...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2014.08.001

    authors: Balint BJ,Steenburg SD,Lin H,Shen C,Steele JL,Gunderman RB

    更新日期:2014-12-01 00:00:00

  • Can Occult Invasive Disease in Ductal Carcinoma In Situ Be Predicted Using Computer-extracted Mammographic Features?

    abstract:RATIONALE AND OBJECTIVES:This study aimed to determine whether mammographic features assessed by radiologists and using computer algorithms are prognostic of occult invasive disease for patients showing ductal carcinoma in situ (DCIS) only in core biopsy. MATERIALS AND METHODS:In this retrospective study, we analyzed ...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2017.03.013

    authors: Shi B,Grimm LJ,Mazurowski MA,Baker JA,Marks JR,King LM,Maley CC,Hwang ES,Lo JY

    更新日期:2017-09-01 00:00:00

  • Investigation of misfiled cases in the PACS environment and a solution to prevent filing errors for chest radiographs.

    abstract:RATIONALE AND OBJECTIVE:The aim of the study was to survey misfiled cases in a picture archiving and communication system environment at two hospitals and to demonstrate the potential usefulness of an automated patient recognition method for posteroanterior chest radiographs based on a template-matching technique desig...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2004.11.008

    authors: Morishita J,Watanabe H,Katsuragawa S,Oda N,Sukenobu Y,Okazaki H,Nakata H,Doi K

    更新日期:2005-01-01 00:00:00

  • Effect of radiologic contrast media on cell volume regulation in rabbit proximal renal tubules.

    abstract:RATIONALE AND OBJECTIVES:Most radiographic contrast media are hyperosmotic and able to shrink cells with which they are in contact. The authors studied cell volume control in rabbit proximal renal tubules after incubation with three contrast media: iohexol, ioxaglate, and iodixanol. MATERIALS AND METHODS:Proximal rena...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/S1076-6332(03)80547-0

    authors: Galtung HK,Løken M,Sakariassen KS

    更新日期:2001-05-01 00:00:00

  • Results of the 1993 survey of the American Association of Academic Chief Residents in Radiology.

    abstract:RATIONALE AND OBJECTIVES:A survey of chief residents of academic radiology programs is conducted annually on behalf of the American Association of Academic Chief Residents in Radiology (A3CR2). Data are obtained to improve the training of diagnostic radiology residents and to increase the understanding of radiologists ...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(05)80835-9

    authors: Oser AB,Baker SM,Wilson AJ,Evens RG

    更新日期:1994-10-01 00:00:00

  • Isotropic reconstruction of SPECT data using OSEM3D: correlation with CT.

    abstract:RATIONALE AND OBJECTIVES:A statistical based iterative single-photon emission-computed tomography (SPECT) reconstruction algorithm (OSEM) modeling the depth-dependent collimator response in three dimensions has recently been introduced (OSEM3D). The aim of this study was to evaluate the axial shape fidelity of OSEM3D i...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2005.12.004

    authors: Römer W,Reichel N,Vija HA,Nickel I,Hornegger J,Bautz W,Kuwert T

    更新日期:2006-04-01 00:00:00

  • Added Value of Bone Subtraction in Dual-energy Digital Radiography in the Detection of Pneumothorax: Impact of Reader Expertise and Medical Specialty.

    abstract:RATIONALE AND OBJECTIVES:This study aimed to determine the value of dual-energy thoracic radiography in the diagnosis of pneumothorax considering the reader's experience. MATERIALS AND METHODS:Forty patients with a suspected pneumothorax, imaged with dual-energy chest radiographs, were divided into two groups: those w...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2017.06.015

    authors: Urbaneja A,Dodin G,Hossu G,Bakour O,Kechidi R,Gondim Teixeira P,Blum A

    更新日期:2018-01-01 00:00:00

  • Quality of communication: different patterns of reporting the location of the tip of a nasogastric tube.

    abstract:PURPOSE:This investigation is part of a prospective National Institutes of Health-funded study evaluating three different methods for estimating the optimal length for placement of a new nasogastric (NG) tube. Abdomen radiographs were required to determine the location of the tube tip. Our objective was to analyze diff...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2012.02.007

    authors: Cohen MD,Ellett M

    更新日期:2012-06-01 00:00:00

  • Identification of noncalcified plaque in young persons with diabetes: an opportunity for early primary prevention of coronary artery disease identified with low-dose coronary computed tomographic angiography.

    abstract:PURPOSE:Coronary computed tomographic angiography (CTA) is a valuable tool for assessing coronary artery disease (CAD). Although statin use is widely recommended for persons with diabetes older than age 40, little is known about the presence and severity of CAD in younger patients with diabetes mellitus (DM). We evalua...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2012.03.013

    authors: Madaj PM,Budoff MJ,Li D,Tayek JA,Karlsberg RP,Karpman HL

    更新日期:2012-07-01 00:00:00

  • Inflammatory breast carcinoma in magnetic resonance imaging: a comparison with locally advanced breast cancer.

    abstract:RATIONALE AND OBJECTIVES:Although inflammatory breast carcinoma (IBC) accounts for 1%-4% of all breast cancer cases, the appearance of this highly malignant tumor in magnetic resonance imaging (MRI) is still not well characterized. The aim of this study was to identify typical imaging features of IBC in comparison with...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2007.09.011

    authors: Renz DM,Baltzer PA,Böttcher J,Thaher F,Gajda M,Camara O,Runnebaum IB,Kaiser WA

    更新日期:2008-02-01 00:00:00

  • Pseudostenosis in vessels adjacent to intracranial aneurysms on volume-rendered 3D angiograms: a phantom study.

    abstract:RATIONALE AND OBJECTIVE:Among artifacts on three-dimensional (3D) angiograms, pseudostenosis in vessels adjacent to intracranial aneurysms has not been described. By using a phantom, artifacts seen in vessels adjacent to intracranial aneurysms on volume-rendered 3D angiograms were assessed. MATERIALS AND METHODS:Using...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2004.12.003

    authors: Yamura M,Hirai T,Korogi Y,Ikushima I,Yamashita Y,Oishi S

    更新日期:2005-03-01 00:00:00

  • Moving Radiology Workflow to the Electronic Health Record: Quantitative and Qualitative Experience From a Large Academic Medical Center.

    abstract:RATIONALE AND OBJECTIVES:To objectively and subjectively evaluate a large, academic radiology department's transition to electronic health record (EHR) centered workflow. MATERIALS AND METHODS:Multiple metrics were compared from before and after the move to EHR-driven workflow. Examination ordering and reading priorit...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2019.02.006

    authors: Wildman-Tobriner B,Thorpe MP,Said N,Ehieli WL,Roth CJ,Jaffe TA

    更新日期:2020-02-01 00:00:00

  • Preoperative Prediction of Ki-67 Status in Breast Cancer with Multiparametric MRI Using Transfer Learning.

    abstract:RATIONALE AND OBJECTIVES:Ki-67 is one of the most important biomarkers of breast cancer traditionally measured invasively via immunohistochemistry. In this study, deep learning based radiomics models were established for preoperative prediction of Ki-67 status using multiparametric magnetic resonance imaging (mp-MRI). ...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2020.02.006

    authors: Liu W,Cheng Y,Liu Z,Liu C,Cattell R,Xie X,Wang Y,Yang X,Ye W,Liang C,Li J,Gao Y,Huang C,Liang C

    更新日期:2021-02-01 00:00:00

  • Corona Virus International Public Health Emergencies: Implications for Radiology Management.

    abstract::The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China in December 2019 and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency. ...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2020.02.003

    authors: Zhang HW,Yu J,Xu HJ,Lei Y,Pu ZH,Dai WC,Lin F,Wang YL,Wu XL,Liu LH,Li M,Mo YQ,Zhang H,Luo SP,Chen H,Lyu GW,Zhou ZG,Liu WM,Liu XL,Song HY,Chen FZ,Zeng L,Zhong H,Guo TT,Hu YQ,Yang XX,Liu PN,Li DF

    更新日期:2020-04-01 00:00:00

  • High-resolution MR imaging of the human eye 2005.

    abstract:RATIONALE AND OBJECTIVES:We studied preparatory strategies for high-resolution human eye in vivo imaging with commercially available magnets and coils. MATERIALS AND METHODS:We imaged normal volunteers on 1.5T systems by Philips, GE, and Siemens, using commercial approximately 9 cm temporomandibular joint receive coil...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2005.10.023

    authors: Bert RJ,Patz S,Ossiani M,Caruthers SD,Jara H,Krejza J,Freddo T

    更新日期:2006-03-01 00:00:00

  • Disorders of lymph flow.

    abstract::Disturbances in blood capillary exchange of fluid, macromolecules, and cells across intact and abnormal microvessels and deranged lymphatic transport are integral, interacting components in disorders of tissue swelling. Lymphedema or low-output failure of the lymph circulation is often indolent for many years before l...

    journal_title:Academic radiology

    pub_type: 杂志文章,评审

    doi:10.1016/s1076-6332(05)80193-x

    authors: Witte CL,Witte MH

    更新日期:1995-04-01 00:00:00

  • Evaluation of Intracranial Vascular Status in Patients with Acute Ischemic Stroke by Time Maximum Intensity Projection CT Angiography: A Preliminary Study.

    abstract:RATIONALE AND OBJECTIVES:To describe the application of time maximum intensity projection CTA (t-MIP CTA) in acute ischemic stroke and compare t-MIP CTA and single-phase CTA (sCTA) in assessing collateral circulation and predicting prognosis. MATERIALS AND METHODS:Twenty-nine acute ischemic stroke patients who underwe...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2019.06.013

    authors: Cao R,Jiang Y,Lu J,Wu G,Zhang L,Chen J

    更新日期:2020-05-01 00:00:00

  • Iohexol: effects on uptake of radioactive iodine in the thyroid and on thyroid function.

    abstract:RATIONALE AND OBJECTIVES:The authors attempted to determine whether the use of nonionic contrast media causes uptake of iodine by the thyroid to be blocked and whether use of these agents could cause iodine-induced hyperthyroidism. MATERIALS AND METHODS:Twenty-eight persons, including 22 with thyroid disease, were inc...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(98)80026-3

    authors: Nygaard B,Nygaard T,Jensen LI,Court-Payen M,Søe-Jensen P,Nielsen KG,Fugl M,Hansen JM

    更新日期:1998-06-01 00:00:00

  • Automated assessment of renal cortical surface roughness from computerized tomography images and its association with age.

    abstract:RATIONALE AND OBJECTIVES:Nephrosclerosis occurs with aging and is characterized by increased kidney subcapsular surface irregularities at autopsy. Assessments of cortical roughness in vivo could provide an important measure of nephrosclerosis. The purpose of this study was to develop and validate an image-processing al...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2014.05.014

    authors: Duan X,Rule AD,Elsherbiny H,Vrtiska TJ,Avula RT,Alexander MP,Lerman LO,McCollough CH

    更新日期:2014-11-01 00:00:00

  • Software-annotated, digitally photographed, and printed MR images: suitability for publication.

    abstract:RATIONALE AND OBJECTIVES:The authors performed this study to evaluate whether digitally photographed, computer-annotated MR images produced by clinical radiologists and printed with an inexpensive photo printer are suitable for publication. MATERIALS AND METHODS:Laser prints of 20 magnetic resonance images of the brai...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(03)80378-1

    authors: Caruso RD,Postel GC,McDonald CS,Aronson BA,Christensen JD

    更新日期:2002-03-01 00:00:00

  • Evaluation of Simulated Lesions as Surrogates to Clinical Lesions for Thoracic CT Volumetry: The Results of an International Challenge.

    abstract:RATIONALE AND OBJECTIVES:To evaluate a new approach to establish compliance of segmentation tools with the computed tomography volumetry profile of the Quantitative Imaging Biomarker Alliance (QIBA); and determine the statistical exchangeability between real and simulated lesions through an international challenge. MA...

    journal_title:Academic radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.acra.2018.07.022

    authors: Robins M,Kalpathy-Cramer J,Obuchowski NA,Buckler A,Athelogou M,Jarecha R,Petrick N,Pezeshk A,Sahiner B,Samei E

    更新日期:2019-07-01 00:00:00

  • Continuous arterial spin-labeling perfusion magnetic resonance imaging of the human testis.

    abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to determine if continuous arterial spin-labeling perfusion magnetic resonance imaging could be used to detect testicular perfusion in human subjects. MATERIALS AND METHODS:Continuous arterial spin-labeling magnetic resonance perfusion imaging was performed in sev...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(03)00576-2

    authors: Pretorius ES,Roberts DA

    更新日期:2004-01-01 00:00:00

  • Semi-automatic segmentation software for quantitative clinical brain glioblastoma evaluation.

    abstract:RATIONALE AND OBJECTIVES:Quantitative measurement provides essential information about disease progression and treatment response in patients with glioblastoma multiforme (GBM). The goal of this article is to present and validate a software pipeline for semi-automatic GBM segmentation, called AFINITI (Assisted Follow-u...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2012.03.026

    authors: Zhu Y,Young GS,Xue Z,Huang RY,You H,Setayesh K,Hatabu H,Cao F,Wong ST

    更新日期:2012-08-01 00:00:00

  • Clinical Outcomes of Patients with Porcelain Gallbladder Diagnosed on CT.

    abstract:PURPOSE:To evaluate diagnostic accuracy and clinical outcomes of patients with porcelain gallbladder (GB) diagnosed on CT. MATERIALS AND METHODS:In this IRB-approved, HIPAA-compliant study, consecutive patients with porcelain gallbladder reported on CT between December 1, 2000 and August 31, 2017 in a tertiary academi...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2020.07.006

    authors: Appel E,Dommaraju S,Siewert B,Gonzalez RS,Camacho A,Park Y,Brook OR

    更新日期:2020-08-04 00:00:00

  • Multi-reader ROC studies with split-plot designs: a comparison of statistical methods.

    abstract:RATIONALE AND OBJECTIVES:Multireader imaging trials often use a factorial design, in which study patients undergo testing with all imaging modalities and readers interpret the results of all tests for all patients. A drawback of this design is the large number of interpretations required of each reader. Split-plot desi...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2012.09.012

    authors: Obuchowski NA,Gallas BD,Hillis SL

    更新日期:2012-12-01 00:00:00

  • Experimentally induced pulmonary arterial occlusion with detachable balloon in pigs: thin-section CT findings.

    abstract:RATIONALE AND OBJECTIVES:The authors evaluated changes of lung attenuation in pigs, with special attention to the mosaic pattern of low attenuation, at thin-section computed tomography (CT) after obstruction of the proximal pulmonary artery with a detachable balloon. MATERIALS AND METHODS:In seven pigs, nine sites of ...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/s1076-6332(98)80241-9

    authors: Kim TK,Im JG,Kim SH,Won HJ,Seo JB,Yeon KM,Han MC

    更新日期:1998-12-01 00:00:00

  • What characterizes academic radiology departments that secure large amounts of external funding for research?

    abstract:RATIONALE AND OBJECTIVES:We sought to identify factors associated with high levels of external research funding in order to provide departments with information that may help them increase their external research funding. MATERIALS AND METHODS:National Institutes of Health (NIH) data on grants were analyzed to identif...

    journal_title:Academic radiology

    pub_type: 杂志文章

    doi:10.1016/j.acra.2006.09.052

    authors: Jonisch AI,Kligerman S,Nagy E,Bhargavan M,Forman HP,Sunshine J

    更新日期:2006-12-01 00:00:00