当前位置： SCI文献检索 > ACADEMIC RADIOLOGY期刊下所有文献 > Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study.

Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study.

Abstract：

RATIONALE AND OBJECTIVES:To characterize the lipidic profile of bone marrow in the calcaneus and femoral neck of healthy, osteopenic, and osteoporotic women, by using magnetic resonance spectroscopy (MRS) at 3T. The final goal was to identify specific metabolites with the potential ability to discriminate between healthy, osteopenic, and osteoporotic subjects. MATERIALS AND METHODS:Sixty-two and thirty three postmenopausal women recruited to investigate calcaneus and femoral neck, respectively, underwent a bone mineral density (BMD) measurement to be classified as healthy subjects (n = 22), osteopenic (n = 45), or osteoporotic (n = 28) patients. MRS spectra were used to quantify and compare bone marrow fat resonances between the three BMD groups. Between-group differences were tested using a Welch analysis of variance. Multiple comparisons were made with the Games-Howell correction. Relationships between pairs of variables were assessed with linear correlation analysis. Reproducibility analysis was performed for all the lipid resonances in both sites. RESULTS:The reproducibility was satisfactory. In femoral neck, methylene (L13), glycerol (L41, L43), and total lipid resonances were significantly lower in healthy as compared to osteoporotic subjects. On the other hand, in calcaneus, L13/glycerol significantly discriminated between osteopenic and osteoporotic subjects whereas L13/(unsaturated lipid) discriminated between healthy and osteopenic group. However, the reproducibility of both unsaturated lipid and glycerol resonances were less optimal. CONCLUSIONS:MRS of bone marrow lipid profiles from peripheral skeletal sites may be a promising tool for screening of large population to identify individuals with or at risk for developing osteoporosis. Moreover, it provides information about the metabolic changes occurring in bone marrow with the development of osteoporosis, which are skeletal site dependent.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Di Pietro G,Capuani S,Manenti G,Vinicola V,Fusco A,Baldi J,Scimeca M,Hagberg G,Bozzali M,Simonetti G,Tarantino U

doi

10.1016/j.acra.2015.11.009

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

273-83

issue

3

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(15)00521-8

journal_volume

23

pub_type

杂志文章

相关文献

ACADEMIC RADIOLOGY文献大全
  • CT-guided Drainage of Deep Pelvic Abscesses via a Percutaneous Presacral Space Approach: A Clinical Report and Review of the Literature.

    abstract：RATIONALE AND OBJECTIVES:Some deep pelvic abscesses are not accessible through anterior or lateral approaches because of the presence of organs and structures. The objective of this study was to assess the feasibility, safety, tolerability, and efficacy of a percutaneous presacral space approach by reviewing our clinic...

    journal_title：Academic radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.acra.2016.06.009

    authors： Peng T,Dong L,Zhu Z,Cui J,Li Q,Li X,Wu H,Wang C,Yang Z

    更新日期：2016-12-01 00:00:00

  • Effects of Patient Size and Radiation Dose on Iodine Quantification in Dual-Source Dual-Energy CT.

    abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to investigate the potential effects of patient size and radiation dose on the accuracy of iodine quantification using dual-source dual-energy computed tomography (CT). MATERIALS AND METHODS:Three phantoms representing different patient sizes were constructed, con...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2019.12.027

    authors： Jiang X,Yang X,Hintenlang DE,White RD

    更新日期：2021-01-01 00:00:00

  • Radiolabeled L-lysine for tumor imaging.

    abstract：RATIONALE AND OBJECTIVES:The aims of this study were to label the versatile amino acid l-lysine with (99m)Tc using 2,3-dimercapto-succinic acid (DMSA) as a chelator, and to assess its tumor imaging feasibility under in vivo and in vitro conditions, and finally to determine the subcellular biodistribution of this radiop...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2006.03.022

    authors： Karacalioglu AO,Yang DJ,Azhdarinia A,Mendez R,Oh C,Kohanim S,Chanda M,Greenwell AC,Yu DF,Kim EE

    更新日期：2006-11-01 00:00:00

  • Interobserver and intraobserver variability in the assessment of pulmonary nodule size on CT using film and computer display methods.

    abstract：RATIONALE AND OBJECTIVES:A critical element in determining biologic behavior of pulmonary nodules is volume and temporal volume change. We evaluate variability in nodule volume among readers and measuring methods. MATERIALS AND METHODS:55 small (<2 cm) lung nodules were measured in long- and short-axis dimensions inde...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2005.04.009

    authors： Bogot NR,Kazerooni EA,Kelly AM,Quint LE,Desjardins B,Nan B

    更新日期：2005-08-01 00:00:00

  • Seventy-Peak Kilovoltage High-Pitch Thoracic Aortic CT Angiography without ECG Gating: Evaluation of Image Quality and Radiation Dose.

    abstract：RATIONALE AND OBJECTIVES:To assess the feasibility of 70-kVp high-pitch non-ECG-gated thoracic aortic computed tomography angiography (CTA) with 40-mL contrast agent compared to 100-kVp standard-pitch CTA with 60-mL contrast agent. MATERIALS AND METHODS:Sixty-seven patients (51 men and 16 women; mean age, 55 ± 14 year...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2015.03.007

    authors： Zhang LJ,Zhao YE,Schoepf UJ,Mangold S,Felmly LM,Li X,Tang CX,Zhou CS,Qi L,Lu GM

    更新日期：2015-07-01 00:00:00

  • Disorders of lymph flow.

    abstract：:Disturbances in blood capillary exchange of fluid, macromolecules, and cells across intact and abnormal microvessels and deranged lymphatic transport are integral, interacting components in disorders of tissue swelling. Lymphedema or low-output failure of the lymph circulation is often indolent for many years before l...

    journal_title：Academic radiology

    pub_type： 杂志文章,评审

    doi：10.1016/s1076-6332(05)80193-x

    authors： Witte CL,Witte MH

    更新日期：1995-04-01 00:00:00

  • Evaluation of hardware-related geometrical distortion in structural MRI at 7 Tesla for image-guided applications in neurosurgery.

    abstract：RATIONALE AND OBJECTIVES:Geometrical distortion is a well-known problem in structural magnetic resonance imaging (MRI), leading to pixel shifts with variations up to several millimeters. Because the main factors of geometrical distortion are proportional to B(0), MRI spatial encoding distortions tend to increase with h...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2011.02.011

    authors： Dammann P,Kraff O,Wrede KH,Özkan N,Orzada S,Mueller OM,Sandalcioglu IE,Sure U,Gizewski ER,Ladd ME,Gasser T

    更新日期：2011-07-01 00:00:00

  • Tumor angiography using high-resolution, three-dimensional magnetic resonance imaging: comparison of gadopentetate dimeglumine and a macromolecular blood-pool contrast agent.

    abstract：RATIONALE AND OBJECTIVES:We compared the peritumoral vascular definition in rats using either a paramagnetic extracellular or a macromolecular contrast medium in combination with high-resolution magnetic resonance (MR) imaging. METHODS:High-resolution, three-dimensional spoiled gradient-refocused acquisition in a stea...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(05)80059-5

    authors： Schwickert HC,Stiskal M,van Dijke CF,Roberts TP,Mann JS,Demsar F,Brasch RC

    更新日期：1995-10-01 00:00:00

  • Independent evaluation of computer classification of malignant and benign calcifications in full-field digital mammograms.

    abstract：RATIONALE AND OBJECTIVES:To evaluate whether a computer-aided diagnosis (CADx) technique can accurately classify breast calcifications in full-field digital mammograms (FFDMs) as malignant or benign. The computer technique was developed previously on screen-film mammograms (SFMs) in which individual calcifications were...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2006.12.012

    authors： Rana RS,Jiang Y,Schmidt RA,Nishikawa RM,Liu B

    更新日期：2007-03-01 00:00:00

  • Radiology residency eCurriculum developed in-house: evaluation of benefits and weaknesses.

    abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to evaluate residents' use of a radiology curriculum CD-ROM designed to provide ready access to the department's curricula, study materials, and Internet resources. MATERIALS AND METHODS:A survey questionnaire eliciting feedback about the usability and value of th...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(03)80085-5

    authors： Bartlett ES,Maley JE,Fajardo LL

    更新日期：2003-06-01 00:00:00

  • Parents of Pediatric Radiology Patients Prefer Timely Reporting and Discussing Results with Referring Providers.

    abstract：RATIONALE AND OBJECTIVES:With the introduction of new communication channels, such as encrypted messaging and online electronic medical record patient portals, there are ever-increasing ways for patients and their families to access their medical information. While patient preferences regarding how they receive the res...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2019.07.010

    authors： Edwards EA,Cote A,Phelps AS,Naeger DM

    更新日期：2020-05-01 00:00:00

  • Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images.

    abstract：RATIONALE AND OBJECTIVES:The authors evaluated whether fast spectroscopic imaging of water and fat resonances can produce high-quality anatomic magnetic resonance (MR) images of rodent tumors and human breast. MATERIALS AND METHODS:Fast MR spectroscopic images of eight rats with mammary tumors were acquired by using a...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(98)80226-2

    authors： Kovar DA,Al-Hallaq HA,Zamora MA,River JN,Karczmar GS

    更新日期：1998-04-01 00:00:00

  • The use of flat panel volumetric computed tomography (fpVCT) in osteoporosis research.

    abstract：RATIONALE AND OBJECTIVES:Improvements in imaging technology have led to the increased use of computed tomography (CT). For example, micro-CT and quantitative CT (QCT) are now often used in osteoporosis research, in which micro-CT is able to analyze small bones or bone samples with high spatial resolution. In contrast, ...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2008.09.017

    authors： Sehmisch S,Dullin C,Zaroban A,Tezval M,Rack T,Schmelz U,Seidlova-Wuttke D,Dunkelberg H,Wuttke W,Marten K,Stuermer KM,Stuermer EK

    更新日期：2009-04-01 00:00:00

  • Coregistration of head CT comparison studies: assessment of clinical utility.

    abstract：RATIONALE AND OBJECTIVES:The authors evaluated the clinical utility of image coregistration in the interpretation of follow-up computed tomographic (CT) studies of the head. MATERIALS AND METHODS:Fourteen patients with 34 intracranial lesions underwent follow-up head CT. The images were coregistered automatically with...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(03)80097-1

    authors： Schellingerhout D,Lev MH,Bagga RJ,Rincon S,Berdichevsky D,Thangaraj V,Gonzalez RG,Alpert NM

    更新日期：2003-03-01 00:00:00

  • Nephrogenic systemic fibrosis and management of high-risk patients.

    abstract：:The purpose of this work is to provide current information on the rapidly evolving subject of nephrogenic systemic fibrosis (NSF), to establish the radiologic approach to the management of high-risk patients for NSF, and to assess the probabilistic risk of NSF compared to contrast induced nephropathy (CIN), as encount...

    journal_title：Academic radiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.acra.2009.01.001

    authors： Altun E,Semelka RC,Cakit C

    更新日期：2009-07-01 00:00:00

  • T1-weighted MRI imaging features of pathologically proven non-pedal osteomyelitis.

    abstract：RATIONALE AND OBJECTIVES:The objective of our study was to determine if the T1-weighted magnetic resonance imaging (MRI) features associated with diabetic pedal osteomyelitis are present in histopathologically proven cases of non-pedal osteomyelitis. MATERIALS AND METHODS:Seventy-five patients with a histopathological...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2012.07.015

    authors： Howe BM,Wenger DE,Mandrekar J,Collins MS

    更新日期：2013-01-01 00:00:00

  • Texture Analysis Based on Preoperative Magnetic Resonance Imaging (MRI) and Conventional MRI Features for Predicting the Early Recurrence of Single Hepatocellular Carcinoma after Hepatectomy.

    abstract：RATIONALE AND OBJECTIVES:To investigate the value of texture analysis and conventional magnetic resonance imaging (MRI) features for predicting the early recurrence (ER) of single hepatocellular carcinoma (HCC) after hepatectomy. MATERIALS AND METHODS:A total of 100 HCC patients were first divided into group A (tumor ...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2018.10.011

    authors： Zhang J,Liu X,Zhang H,He X,Liu Y,Zhou J,Guo D

    更新日期：2019-09-01 00:00:00

  • Magnetic resonance imaging of mesenchymal stem cells labeled with dual (MR and fluorescence) agents in rat spinal cord injury.

    abstract：RATIONALE AND OBJECTIVES:In vivo tracking cells using gadolinium-based contrast agents have the important advantage of providing a positive contrast on T1-weighted images, which is less likely to be confused with artifacts because of postoperative local signal voids such as metal, hemorrhage, or air. The aim of this st...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2009.03.016

    authors： Shen J,Zhong XM,Duan XH,Cheng LN,Hong GB,Bi XB,Liu Y

    更新日期：2009-09-01 00:00:00

  • Automatic Breast and Fibroglandular Tissue Segmentation in Breast MRI Using Deep Learning by a Fully-Convolutional Residual Neural Network U-Net.

    abstract：RATIONALE AND OBJECTIVES:Breast segmentation using the U-net architecture was implemented and tested in independent validation datasets to quantify fibroglandular tissue volume in breast MRI. MATERIALS AND METHODS:Two datasets were used. The training set was MRI of 286 patients with unilateral breast cancer. The segme...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2019.01.012

    authors： Zhang Y,Chen JH,Chang KT,Park VY,Kim MJ,Chan S,Chang P,Chow D,Luk A,Kwong T,Su MY

    更新日期：2019-11-01 00:00:00

  • Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation.

    abstract：RATIONALE AND OBJECTIVES:Pulmonary vascular alteration is one of the characteristic features of chronic obstructive pulmonary disease (COPD). Recent studies suggest that vascular alteration is closely related to endothelial dysfunction and may be further influenced by emphysema. However, the relationship between morpho...

    journal_title：Academic radiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.acra.2009.07.022

    authors： Matsuoka S,Washko GR,Dransfield MT,Yamashiro T,San Jose Estepar R,Diaz A,Silverman EK,Patz S,Hatabu H

    更新日期：2010-01-01 00:00:00

  • Comparison of image acquisition and radiologist interpretation times in a diagnostic mammography center.

    abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to determine the acquisition and interpretation times of screen-film mammography and soft-copy digital mammography in a diagnostic mammography center. MATERIALS AND METHODS:The study was conducted in three phases for patients presenting for clinical diagnostic wor...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2010.04.018

    authors： Kuzmiak CM,Cole E,Zeng D,Kim E,Koomen M,Lee Y,Pavic D,Pisano ED

    更新日期：2010-09-01 00:00:00

  • Attenuation of contrast material-induced renal artery vasoconstriction by nitric oxide donors.

    abstract：RATIONALE AND OBJECTIVES:The authors studied the role of the endothelium and associated endothelial pathways in contrast material-induced renal vasoconstriction. MATERIALS AND METHODS:Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine an...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(97)80254-1

    authors： Drescher P,Madsen PO

    更新日期：1997-12-01 00:00:00

  • Automated segmentation of the liver from 3D CT images using probabilistic atlas and multilevel statistical shape model.

    abstract：RATIONALE AND OBJECTIVES:An atlas-based automated liver segmentation method from three-dimensional computed tomographic (3D CT) images has been developed. The method uses two types of atlases, a probabilistic atlas (PA) and a statistical shape model (SSM). MATERIALS AND METHODS:Voxel-based segmentation with a PA is fi...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2008.07.008

    authors： Okada T,Shimada R,Hori M,Nakamoto M,Chen YW,Nakamura H,Sato Y

    更新日期：2008-11-01 00:00:00

  • Continuous arterial spin-labeling perfusion magnetic resonance imaging of the human testis.

    abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to determine if continuous arterial spin-labeling perfusion magnetic resonance imaging could be used to detect testicular perfusion in human subjects. MATERIALS AND METHODS:Continuous arterial spin-labeling magnetic resonance perfusion imaging was performed in sev...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(03)00576-2

    authors： Pretorius ES,Roberts DA

    更新日期：2004-01-01 00:00:00

  • Computerized delineation and analysis of costophrenic angles in digital chest radiographs.

    abstract：RATIONALE AND OBJECTIVES:The authors developed a computerized method for delineating the costophrenic angles in digital posteroanterior chest radiographs to derive quantitative information that allows for detection of abnormal blunting of the costophrenic angle. MATERIALS AND METHODS:An automated lung-segmentation sch...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(98)80151-7

    authors： Armato SG 3rd,Giger ML,MacMahon H

    更新日期：1998-05-01 00:00:00

  • Determining optimal acquisition parameters for computed tomography coronary angiography: evaluation of a software-assisted, breathhold exam simulation.

    abstract：RATIONALE AND OBJECTIVES:Scanning parameters used in multislice computed tomographic (MSCT) coronary angiography should be adapted to patients' heart rates. The aim of this study was to evaluate the rate of success of a software-assisted scan simulation to determine optimal gantry rotation time prior to MSCT coronary a...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2008.08.016

    authors： Engelken FJ,Lembcke A,Hamm B,Dewey M

    更新日期：2009-02-01 00:00:00

  • Evaluation of the effect of computer-aided classification of benign and malignant lesions on reader performance in automated three-dimensional breast ultrasound.

    abstract：RATIONALE AND OBJECTIVES:To investigate the effect of a newly developed computer-aided diagnosis (CAD) system on reader interpretation of breast lesions in automated three-dimensional (3D) breast ultrasound. MATERIALS AND METHODS:A CAD system was developed to differentiate malignant lesions from benign lesions includi...

    journal_title：Academic radiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.acra.2013.07.013

    authors： Tan T,Platel B,Twellmann T,van Schie G,Mus R,Grivegnée A,Mann RM,Karssemeijer N

    更新日期：2013-11-01 00:00:00

  • 3D shape analysis of the supraspinatus muscle: a clinical study of the relationship between shape and pathology.

    abstract：RATIONALE AND OBJECTIVES:Rotator cuff disorders are prevalent and can cause pain and reduced range of motion and strength. Accurate, noninvasive diagnosis of rotator cuff disorders is therefore important. In this work, we study the relationship between several three-dimensional (3D) shape measurements of the supraspina...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/j.acra.2007.06.014

    authors： Ward AD,Hamarneh G,Ashry R,Schweitzer ME

    更新日期：2007-10-01 00:00:00

  • Accuracy of Computed Tomographic Enterography for Obscure Gastrointestinal Bleeding: A Diagnostic Meta-analysis.

    abstract：RATIONALE AND OBJECTIVES:Obscure gastrointestinal bleeding (OGIB) is the bleeding from the gastrointestinal tract without definite source that persists and recurs after a negative endoscopic evaluation. The study aimed to systematically evaluate the diagnostic accuracy of computed tomography enterography on OGIB detect...

    journal_title：Academic radiology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.acra.2017.09.001

    authors： He B,Yang J,Xiao J,Gu J,Chen F,Wang L,Qian J,Gong S

    更新日期：2018-02-01 00:00:00

  • Percutaneous implantation of non-small-cell lung carcinoma: technique and observations.

    abstract：RATIONALE AND OBJECTIVES:The authors performed this study to determine whether intrathoracic inoculation of non-small-cell lung carcinoma with fluoroscopic guidance would provide for more accurate implantation. MATERIALS AND METHODS:A tumor cell inoculum (2 x 10(6) cells per 0.15 mL) was injected percutaneously under ...

    journal_title：Academic radiology

    pub_type： 杂志文章

    doi：10.1016/s1076-6332(05)80267-3

    authors： Hamide JP,Qian Z,Xu H,Diethelm L,Skrepnik N,Castaneda-Zuniga WR,Hunt JD

    更新日期：1997-09-01 00:00:00