Abstract:
RATIONALE AND OBJECTIVES:The aim of this study was to identify clinically useful tumor/normal brain apparent diffusion coefficient (ADC) ratios for distinguishing common pediatric cerebellar tumors. MATERIALS AND METHODS:Review of medical records revealed 79 patients with cerebellar tumors who underwent preoperative magnetic resonance imaging, including diffusion-weighted imaging sequences, and surgery. There were 31 pilocytic astrocytomas, 27 medulloblastomas, 14 ependymomas, and seven atypical teratoid/rhabdoid tumors. ADC values were measured by placing regions of interest on the solid tumor and normal brain parenchyma by two reviewers. Tumor/normal brain ADC ratios were calculated. RESULTS:Mean ADC values of the pilocytic astrocytomas were greater than those of ependymomas, whose mean ADC values were greater than those of medulloblastomas and atypical teratoid/rhabdoid tumors. Using a tumor/normal brain ADC ratio threshold of 1.70 to distinguish pilocytic astrocytomas from ependymomas, sensitivity of 92% and specificity of 79% were achieved. A tumor/normal brain ADC ratio threshold of 1.20 enabled the sorting of ependymomas from medulloblastomas with sensitivity of 93% and specificity of 88%. CONCLUSIONS:Tumor/normal brain ADC ratios allow the distinguishing of common pediatric cerebellar tumors.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Gimi B,Cederberg K,Derinkuyu B,Gargan L,Koral KM,Bowers DC,Koral Kdoi
10.1016/j.acra.2012.03.004subject
Has Abstractpub_date
2012-07-01 00:00:00pages
794-800issue
7eissn
1076-6332issn
1878-4046pii
S1076-6332(12)00146-8journal_volume
19pub_type
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