Abstract:
RATIONALE AND OBJECTIVES:Morphologic changes of the human brain during healthy aging provide useful reference knowledge for age-related brain disorders. The aim of this study was to explore age-related global and regional morphological changes of healthy adult brains. MATERIALS AND METHODS:T1-weighted magnetic resonance images covering the entire brain were acquired for 314 subjects. Image processing of registration, segmentation, and surface construction were performed to calculate the volumes of the cerebrum, cerebellum, brain stem, lateral ventricle, and subcortical nuclei, as well as the surface area, mean curvature index, cortical thickness of the cerebral cortex, and subjacent white matter volume using FreeSurfer software. Mean values of each morphologic index were calculated and plotted against age group for sectional analysis. Regression analysis was conducted using SPSS to investigate the age effects on global and regional volumes of human brain. RESULTS:Overall global and regional volume loss was observed for the entire brain during healthy aging. Moderate atrophy was observed in subcortical gray matter structures, including the thalamus (R(2) = 0.476, P < .001), nucleus accumbens (R(2) = 0.525, P < .001), pallidum (R(2) = 0.461, P < .001), and putamen (R(2) = 0.533, P < .001). The volume of hippocampus showed a slight increase by 40 years of age, followed by a relatively faster decline after the age of 50 years (R(2) = 0.486, P < .001). Surface area and mean curvature were less affected by aging relative to cortical thickness and subjacent white matter volume. Significant cortical thinning was mainly found in the parietal (R(2) = 0.553, P < .001) and insula regions (R(2) = 0.405, P < .001). CONCLUSIONS:Morphologic alterations of human brain manifested regional heterogeneity in the scenario of general volume loss during healthy aging. The age effect on the hippocampus demonstrated a unique evolution. These findings provide informative reference knowledge that may help in identifying and differentiating pathologic aging and other neurologic disorders.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Long X,Liao W,Jiang C,Liang D,Qiu B,Zhang Ldoi
10.1016/j.acra.2012.03.006subject
Has Abstractpub_date
2012-07-01 00:00:00pages
785-93issue
7eissn
1076-6332issn
1878-4046pii
S1076-6332(12)00148-1journal_volume
19pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:Primary dilated cardiomyopathy is a disease of unknown etiology, and it leads to severe heart failure. Abnormalities of the cardiac metabolism can play an important role in prognosis and influence the symptomatology in this group. The aim of this study was to assess cardiac metabolism using pro...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00104-1
更新日期:2003-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Evidence is inconsistent about whether radiologists' interpretive performance on a screening mammography test set reflects their performance in clinical practice. This study aimed to estimate the correlation between test set and clinical performance and determine if the correlation is influence...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.03.016
更新日期:2017-10-01 00:00:00
abstract::The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China in December 2019 and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency. ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.02.003
更新日期:2020-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Previous cross-sectional studies have demonstrated that airway wall thickness and air trapping are greater in subjects with severe asthma than in those with mild-to-moderate asthma. However, a better understanding of how airway remodeling and lung density change over time is needed. This study ...
journal_title:Academic radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.acra.2014.05.001
更新日期:2014-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Comprehensive training in cardiac imaging during radiology residency is imperative if radiologists are to maintain a significant role in this rapidly growing field. In this study, radiology chief residents were surveyed to assess the current status of cardiac imaging training in radiology resid...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.02.002
更新日期:2010-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to evaluate the intratumoral residence time of microbubbles (MBs) targeted to alpha(v)beta(3) integrin expressed in the endothelial cells of mice during the process of tumor angiogenesis. MATERIALS AND METHODS:For the preparation of MBs, decafluorobutane gas was sonic...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.07.017
更新日期:2010-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We surveyed radiology residents to understand which information sources residents use to learn radiology. MATERIALS AND METHODS:A 15-question survey on learning resources was given to radiology residents at one institution. The survey queried residents about their preferences for sources when ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.06.002
更新日期:2007-09-01 00:00:00
abstract::The three missions of academic radiology compete with one another for time and funding. Revenue for the clinical mission often subsidizes education and research. Given the internal and external drivers/pressures on health care and, more particularly, on academic health centers, the current model is unsustainable. Tren...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2013.04.003
更新日期:2013-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of our study was to evaluate magnetic resonance (MR) artifacts related to breast tissue markers in breast imaging procedures. MATERIALS AND METHODS:In this bicentric prospective ex vivo study 10 different commercially available markers were measured in self-made breast phantoms. Br...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.12.006
更新日期:2021-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study compares the performance of T2 maps in the detection of prostate cancer (PCa) in comparison to T2-weighted (T2W) magnetic resonance images. MATERIALS AND METHODS:The prospective study was institutional review board approved. Consenting patients (n = 45) with histologic confirmed PCa...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.04.005
更新日期:2019-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To establish the range of normal for quantitative computed tomography (CT)-based measures of lung structure and function, we seek to develop methods for matching pulmonary structures across individuals and establishing a normative human lung atlas. MATERIALS AND METHODS:In our previous work, w...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.04.025
更新日期:2012-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Cardiovascular (CV) disease is predominately influenced by CV risk factors and coronary computed tomography angiography (CTA) is capable of detecting early-stage coronary artery disease. We sought to determine the influence of CV risk factors on the prevalence of nonobstructive atherosclerosis ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.12.005
更新日期:2017-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to identify clinically useful tumor/normal brain apparent diffusion coefficient (ADC) ratios for distinguishing common pediatric cerebellar tumors. MATERIALS AND METHODS:Review of medical records revealed 79 patients with cerebellar tumors who underwent preoperative m...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.03.004
更新日期:2012-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate clinical and imaging features associated with adequacy of the hepatocyte phase (HP) in gadoxetate disodium-enhanced liver magnetic resonance imaging (MRI) in patients without chronic liver disease (CLD). MATERIALS AND METHODS:This was a retrospective institutional review board-appr...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.02.005
更新日期:2014-06-01 00:00:00
abstract:RATIONAL AND OBJECTIVES:Computer-aided detection (CAD) systems are intended to improve performance. This study investigates how CAD might actually interfere with a visual search task. This is a laboratory study with implications for clinical use of CAD. METHODS:Forty-seven naive observers in two studies were asked to ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.05.013
更新日期:2012-10-01 00:00:00
abstract::Imaging screening examinations are growing in their indications and volume to identify conditions at an early, treatable stage. The Radiology Research Alliance's 'Role of Imaging in Health Screening' Task Force provides a review of imaging-based screening rationale, economics, and describes established guidelines by v...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.03.038
更新日期:2020-05-11 00:00:00
abstract:RATIONALE AND OBJECTIVES:Because it is imperative for understanding the performance of dual-energy computed tomography scanner to determine clinical diagnosis, we aimed to assess the accuracy of quantitative measurements using dual-energy computed tomography with fast kilovoltage switching. MATERIALS AND METHODS:Quant...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.11.002
更新日期:2018-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Manganese is a well-known liver-specific agent used in magnetic resonance imaging. For this purpose, manganese is now administered intravenously. In theory it should be possible to increase the gastrointestinal uptake of manganese through the use of nutritional products as promoters. Such an ag...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00571-3
更新日期:2004-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aims of this study were to quantify resident anxiety when beginning independent call and to assess whether an apprenticeship experience (buddy call) can lessen anxiety and improve confidence. MATERIALS AND METHODS:A prospective cohort comparison of two groups of radiology residents beginni...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.04.015
更新日期:2011-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:In assessing diagnostic accuracy it is often essential to determine the reader's ability both to detect and to correctly locate multiple abnormalities per patient. The authors developed a new approach for the detection and localization of multiple abnormalities and compared it with other approa...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(00)80324-4
更新日期:2000-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine computed tomography (CT) radiological features and texture features that are rewarding in differentiating nonhypervascular pancreatic neuroendocrine neoplasms (PNENs) from pancreatic ductal adenocarcinomas (PDACs). MATERIALS AND METHODS:We compared patients to pathologically prove...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.06.012
更新日期:2020-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aims of this study were to label the versatile amino acid l-lysine with (99m)Tc using 2,3-dimercapto-succinic acid (DMSA) as a chelator, and to assess its tumor imaging feasibility under in vivo and in vitro conditions, and finally to determine the subcellular biodistribution of this radiop...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.03.022
更新日期:2006-11-01 00:00:00
abstract::This review article presents the current evidence of the importance of integrating radiology and anatomy in medical education in the UK, a recommendation by a number of key anatomy, education, and radiology organizations. Current evidence highlights that on average only 5% of total teaching time in medical education i...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2015.12.010
更新日期:2016-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We studied preparatory strategies for high-resolution human eye in vivo imaging with commercially available magnets and coils. MATERIALS AND METHODS:We imaged normal volunteers on 1.5T systems by Philips, GE, and Siemens, using commercial approximately 9 cm temporomandibular joint receive coil...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.10.023
更新日期:2006-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the capability of delta-radiomics to predict pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). MATERIALS AND METHODS:This retrospective study enrolled 165 consecutive patients with LARC (traini...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.10.026
更新日期:2020-11-11 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate the performance of diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI) in discriminating benign tissue, low- and high-grade prostate adenocarcinoma (PCa). MATERIALS AND METHODS:Forty-eight patients with biopsy-proven PCa of different Gleason grade (GG), who provi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.11.015
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:This study was to investigate the CT quantification of COVID-19 pneumonia and its impacts on the assessment of disease severity and the prediction of clinical outcomes in the management of COVID-19 patients. MATERIALS METHODS:Ninety-nine COVID-19 patients who were confirmed by positive nucleic acid test (NAT...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.09.004
更新日期:2020-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:SYNTAX score is a useful metric determined at the time of invasive coronary angiography (ICA) to assess the complexity of coronary artery disease, and improves prediction of complications at the time of percutaneous complex intervention (PCI). We aimed to determine whether SYNTAX score can be r...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.07.003
更新日期:2016-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A survey of chief residents of academic radiology programs is conducted annually on behalf of the American Association of Academic Chief Residents in Radiology (A3CR2). Data are obtained to improve the training of diagnostic radiology residents and to increase the understanding of radiologists ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80835-9
更新日期:1994-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Radiology faces a severe and growing shortage of radiologic technologists. One way of redressing this problem is to improve the quality of education provided to radiologic technology students. Yet growing clinical demands increasingly erode faculty time for teaching. This study examined whether ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80029-6
更新日期:2003-04-01 00:00:00