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Increased manganese concentration in the liver after oral intake.

Abstract：

RATIONALE AND OBJECTIVES:Manganese is a well-known liver-specific agent used in magnetic resonance imaging. For this purpose, manganese is now administered intravenously. In theory it should be possible to increase the gastrointestinal uptake of manganese through the use of nutritional products as promoters. Such an agent has now been formulated. As part of a primary pharmacologic investigation, the uptake of manganese in the kidney, heart, and liver was studied. MATERIALS AND METHODS:One hundred two female Sprague Dawley rats fasted for 18 hours before the agent (CMC-001) was given orally by gavage. One hundred micromol/kg BW was given to all rats except six, who served as controls. Various concentrations of the promoters (vitamin D3 and the amino acid alanine) were also given. Three hours after administration the rats were killed and the heart, the liver and kidneys were removed. The manganese content was determined by atomic absorption. RESULTS:No systematic increased concentration of manganese was found in either the kidneys or the heart; whereas the manganese content of the liver (approximately 100%) increased significantly compared with the controls and the group receiving pure manganese. No side effects were observed. CONCLUSION:It is possible to increase the gastrointestinal uptake of manganese in fasting rats and thereby increase the concentration in the liver.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Thomsen HS,Svendsen O,Klastrup S

doi

10.1016/s1076-6332(03)00571-3

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

38-44

issue

1

eissn

1076-6332

issn

1878-4046

journal_volume

11

pub_type

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