Abstract：
RATIONALE AND OBJECTIVES:Photodynamic therapy (PDT) is a promising strategy for treating cancer. PDT involves three components: a photosensitizer (PS) drug, a specific wavelength of drug-activating light, and oxygen. A challenge in PDT is the unknown biodistribution of the PS in the target tissue. In this preliminary study, we report the development of a new approach to image in three dimensions the PS biodistribution in a noninvasive and fast manner. MATERIALS AND METHODS:A mesoscopic fluorescence tomography imaging platform was used to image noninvasively the biodistribution of 2-[1-hexyloxyethyl]-2 devinyl pyropheophorbide-a (HPPH) in preclinical skin cancer models. Seven tumors were imaged and optical reconstructions were compared to nonconcurrent ultrasound data. RESULTS:Successful imaging of the HPPH biodistribution was achieved on seven skin cancer tumors in preclinical models with a typical acquisition time of 1 minute. Two-dimensional fluorescence signals and estimated three-dimensional PS distributions were located within the lesions. However, HPPH distribution was highly heterogeneous with the tumors. Moreover, HPPH distribution volume and tumor volume as estimated by ultrasound did not match. CONCLUSIONS:The results of this proof-of-concept study demonstrate the potential of MFMT to image rapidly the HPPH three-dimensional biodistribution in skin cancers. In addition, these preliminary data indicate that the PS biodistribution in skin cancer tumors is heterogeneous and does not match anatomical data. Mesoscopic fluorescence molecular tomography, by imaging fluorescence signals over large areas with high spatial sampling and at fast acquisition speeds, may be a new imaging modality of choice for planning and optimizing of PDT treatment.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Ozturk MS,Rohrbach D,Sunar U,Intes Xdoi
10.1016/j.acra.2013.11.009subject
Has Abstractpub_date
2014-02-01 00:00:00pages
271-80issue
2eissn
1076-6332issn
1878-4046pii
S1076-6332(13)00542-4journal_volume
21pub_type
杂志文章,评审abstract：RATIONALE AND OBJECTIVES:The purpose of this study is to quantify the clinical impact of resident-attending discrepancies at a tertiary referral academic radiology residency program by assessing rates of intervention, discrepancy confirmation, recall rate, and management change rate; furthermore, a discrepancy categori...
journal_title：Academic radiology
pub_type： 杂志文章
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abstract：:The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China in December 2019 and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency. ...
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journal_title：Academic radiology
pub_type： 杂志文章,meta分析,评审
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更新日期：2018-02-01 00:00:00
abstract：:We discuss the benefits of maintaining an active, rigorous, and highly structured grand rounds (GR) program in an academic radiology department. These benefits include education for faculty (continuing medical education), fellows, and residents and a venue for building collaboration and camaraderie within the departme...
journal_title：Academic radiology
pub_type： 杂志文章
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abstract：RATIONALE AND OBJECTIVES:Amphiphilic biocompatible polyoxyethylene (PEO)-based polymers form particles (micelles) that are 10-50 nm in diameter. In the current research, we successfully incorporated amphiphilic indium-111 (111In) and gadolinium chelates into these particles and used them as particulate contrast media i...
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abstract：RATIONALE AND OBJECTIVE:Radiology faces a severe and growing shortage of radiologic technologists. One way of redressing this problem is to improve the quality of education provided to radiologic technology students. Yet growing clinical demands increasingly erode faculty time for teaching. This study examined whether ...
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journal_title：Academic radiology
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doi：10.1016/j.acra.2009.03.016
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pub_type： 杂志文章,多中心研究
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更新日期：2018-07-01 00:00:00
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journal_title：Academic radiology
pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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journal_title：Academic radiology
pub_type： 杂志文章
doi：10.1016/j.acra.2007.06.002
更新日期：2007-09-01 00:00:00
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journal_title：Academic radiology
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更新日期：2020-02-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:Studies of medical school clerkship websites have reported efficient time management, resource utilization, and hands-on activities. We built a website devoted to medical student education in radiology to address student, educator, and school curricular needs and surveyed students to assess the...
journal_title：Academic radiology
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doi：10.1016/j.acra.2020.08.021
更新日期：2020-09-21 00:00:00
abstract：RATIONALE AND OBJECTIVES:To investigate a multimodality computer-aided diagnosis (CAD) scheme that combines image information from full-field digital mammography (FFDM) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for computerized breast cancer classification. MATERIALS AND METHODS:From a retrosp...
journal_title：Academic radiology
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更新日期：2010-09-01 00:00:00
abstract：RATIONALE AND OBJECTIVES:The purpose of this study was to compare the efficacy of dual-energy computed tomography (DECT), time-resolved magnetic resonance (MR) imaging (MRI) perfusion measurements, and high-resolution MR angiography (MRA) for the detection of pulmonary embolism (PE) in a rabbit model. MATERIALS AND ME...
journal_title：Academic radiology
pub_type： 杂志文章
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journal_title：Academic radiology
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abstract：RATIONALE AND OBJECTIVES:Three-dimensional (3D) printing is attracting increasing attention in the medical field. This study aimed to apply 3D printing to the production of hollow splenic artery aneurysm models for use in the simulation of endovascular treatment, and to evaluate the precision and accuracy of the simula...
journal_title：Academic radiology
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更新日期：2017-05-01 00:00:00
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journal_title：Academic radiology
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abstract：RATIONALE AND OBJECTIVES:We evaluated the inter- and intraobserver reproducibility of measuring five morphologic parameters of the anorectum in defecography (evacuation proctography). METHODS:Measurements from 42 defecographic studies were statistically analyzed. The parameters measured during resting, squeezing, and ...
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pub_type： 杂志文章
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abstract：RATIONALE AND OBJECTIVES:It was hypothesized that perfusion computed tomography (CT), blood flow (BF), blood volume (BV), and vascular permeability surface area (PS) product parameters would be predictive of therapeutic anticancer agent uptake in pancreatic cancer, facilitating image-guided interpretation of human trea...
journal_title：Academic radiology
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abstract：RATIONALE AND OBJECTIVES:Extraprostatic extension of disease (EPE) has a major role in risk stratification of prostate cancer patients. Currently, pretreatment local staging is performed with MRI, while the gold standard is represented by histopathological analysis after radical prostatectomy. Texture analysis (TA) is ...
journal_title：Academic radiology
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abstract：RATIONALE AND OBJECTIVES:Several methods have been proposed for estimating the standard error (SE) of the area under the curve (AUC) in receiver operating characteristic analysis. The authors examined the validity of three methods--the LABROC procedure, exponential approximation, and the method of DeLong et al (purely ...
journal_title：Academic radiology
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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