Abstract：
RATIONALE AND OBJECTIVES:To evaluate, in a group of candidates for liver donation, the role of unenhanced computed tomography (CT) and magnetic resonance (MR) as noninvasive means to measure hepatic steatosis (HS). MATERIALS AND METHODS:Sixty-one consecutive candidates underwent CT and MR evaluation for liver donation within 3 weeks of liver biopsy. On CT, three methods of HS quantification were evaluated: the measurement of hepatic attenuation (CT L), the ratio of hepatic attenuation to splenic attenuation (CT L/S), and the difference between the hepatic and splenic attenuation (CT L-S). On MR, HS was reported in terms of fat signal fraction (FSF) using in-phase/opposed-phase and fat/non-fat- saturated images, with and without normalization with the spleen (T1W IP/OP FSF, T1W IP/OP FSF spleen and T2W ± FS FSF, TW2 ± FS FSF spleen). The accuracy of each imaging index in the diagnosis of HS, according to various thresholds, was assessed using receiver operating characteristic analysis. RESULTS:On biopsy, 35 donors showed no significant HS (<5%); the remaining 26 showed HS ranging from 5% to 40%. With all CT and MR indices, there was a trend toward increasing diagnostic accuracy as the threshold levels of HS increased. When comparing all the indices, TW2 ± FS FSF(spl) showed higher accuracy at threshold levels of 5% and 10% of steatosis but without reaching statistical significance. CONCLUSIONS:In candidates for living donation, MR and CT indices are similar in estimating liver-fat content; however, MR with T2W ± FS FSF(spl) sequences shows higher accuracy when low threshold levels of steatosis (≤5% and ≤10% HS) are selected.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Maruzzelli L,Parr AJ,Miraglia R,Tuzzolino F,Luca Adoi
10.1016/j.acra.2014.01.007subject
Has Abstractpub_date
2014-04-01 00:00:00pages
507-13issue
4eissn
1076-6332issn
1878-4046pii
S1076-6332(14)00010-5journal_volume
21pub_type
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