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Imaging evidence for renomegaly in patients with POEMS syndrome.

Abstract：

RATIONALE AND OBJECTIVES:Organomegaly in POEMS syndrome generally refers to the liver, spleen, and lymph nodes. This study investigates whether there is a significant difference in kidney sizes in patients with POEMS compared to normal controls. MATERIALS AND METHODS:Calculated kidney volumes from 77 patients with POEMS syndrome who had undergone imaging by computed tomography or magnetic resonance imaging were compared to frequency-matched controls. For the POEMS patients and the controls, the volume of each kidney was obtained from a three-dimensional segmentation algorithm. Univariate and multiple variable linear regression models were used to identify any differences in kidney size between normal and POEMS patients. RESULTS:There was a univariate statistically significant association between disease state and the difference in kidney volume; having POEMS was associated with 16.3 cm(3) greater kidney volume difference compared to control patients, P < .001. Using a multiple variable model and after adjusting for age, sex, and the smaller kidney size, there was a statistically significant association between disease state and the difference in kidney volume; having POEMS was associated with 16.8 cm(3) greater kidney volume compared to control patients, P < .001. There was not an independent statistically significant association between age, sex, or volume of the smaller kidney and the difference in kidney volume. CONCLUSION:This confirms what is known or suspected clinically, that organomegaly in POEMS includes renomegaly.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Clapp AJ,Lee CU,Wood-Wentz CM,Leung N,Dispenzieri A

doi

10.1016/j.acra.2011.05.008

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

1241-4

issue

10

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(11)00256-X

journal_volume

18

pub_type

历史文章,杂志文章

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