Abstract:
RATIONALE AND OBJECTIVES:Tumor grading of nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) determines the choice of clinical treatment and management. The pathological grade of pancreatic neuroendocrine tumors is usually assessed on postoperative specimens. The goal of our study is to establish a tumor grade (G) prediction model for preoperative G1/2 NF-pNETs using radiomics for multislice spiral CT image analysis. MATERIALS AND METHODS:This retrospective study included a primary cohort of 59 patients and an independent validation cohort of 40 consecutive patients; their multislice spiral CT images were collected from October 2012 to October 2016 and October 2016 to June 2018, respectively. All 99 patients were diagnosed with clinicopathologically confirmed NF-pNETs. Most significant radiomic features were selected using the minimum redundancy and maximum relevance algorithm. Support vector machine classifier with a radial basis function-based predictive model was subsequently developed for clinical use. RESULTS:A total of 585 radiomics features were extracted from every phase for each patient. Six of these radiomics features were identified as most discriminant features for G1 and G2 tumors and used to construct the tumor grade prediction model. The prediction model resulted in the area under the curve values of 0.968 (95% CI: 0.900-0.991) and 0.876 (95% CI: 0.700-0.963) for the training cohort and validation cohort, respectively. Sensitivity and specificity were 96.4% and 83.9%, and 90.9% and 88.9% for the training and validation cohorts, respectively. The decision curves indicated that if the threshold probability is above 0.1, using the rad-score in the current study on G1/2 NF-pNETs is more beneficial than the treat-all-patients scheme or the treat-none scheme. CONCLUSION:Radiomics developed with a combination of nonenhanced and portal venous phases can achieve favorable predictive accuracy for histological grade for G1/G2 NF-pNETs.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Zhao Z,Bian Y,Jiang H,Fang X,Li J,Cao K,Ma C,Wang L,Zheng J,Yue X,Zhang H,Wang X,Madabhushi A,Xu J,Jin G,Lu Jdoi
10.1016/j.acra.2020.01.002subject
Has Abstractpub_date
2020-12-01 00:00:00pages
e272-e281issue
12eissn
1076-6332issn
1878-4046pii
S1076-6332(20)30020-9journal_volume
27pub_type
杂志文章abstract:RATIONALE AND OBJECTIVE:We sought to establish medical students' perspectives of a set of curriculum topics for radiology teaching. MATERIALS AND METHODS:A multicenter study was conducted in New Zealand. A modified Delphi method was adopted. Students enrolled in two New Zealand Universities received a questionnaire. E...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acra.2006.02.034
更新日期:2006-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To evaluate the ex vivo ablation zones created in hepatic tissue using monopolar and bipolar gas- and water-cooled radiofrequency (RF) applicators. MATERIALS AND METHODS:RF ablations were performed on ex vivo bovine liver tissue using closed circuit water-cooled and closed circuit cryogenicall...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.02.004
更新日期:2014-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to evaluate the American College of Radiology (ACR) accreditation phantom for assessing image quality in digital mammography. MATERIALS AND METHODS:Digital images were obtained of an ACR accreditation phantom at varying mAs (constant kVp) and varying kVp (constant...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80345-8
更新日期:2002-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Inguinal lymph nodes can be the first or the only clinical signs of tumor metastases. The aim of the study was to evaluate the role of contrast-enhanced high-resolution magnetic resonance (MR) lymphangiography in diagnosis of inguinal lymph node metastases. MATERIALS AND METHODS:The study enro...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.09.014
更新日期:2013-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied the role of the endothelium and associated endothelial pathways in contrast material-induced renal vasoconstriction. MATERIALS AND METHODS:Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine an...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80254-1
更新日期:1997-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine graduating medical students' perceptions of radiology and to document changes in their perceptions since they entered medical school. MATERIALS AND METHODS:A survey questionnaire was distributed to 213 graduating students. Questions were similar to those answered by the same group...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80211-5
更新日期:1997-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors' purpose was to search the inversion time (TI) values that enable the best differentiation of fine structures in gray matter (gray-gray differentiation). MATERIALS AND METHODS:Seven healthy adult volunteers with no history of neurologic disease or head trauma were recruited and gav...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80789-4
更新日期:2003-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Designed to provide broad-based training in all aspects of imaging, the diagnostic radiology residency program must provide educational experiences that not only provide technical training, but also meet accreditation standards. With the breadth of material to cover during training, carefully o...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.12.022
更新日期:2021-01-21 00:00:00
abstract:RATIONALE AND OBJECTIVES:A survey was administered to fourth-year radiology residents after receiving their results from the first American Board of Radiology (ABR) Core examination in 2013. The purpose was to gather information regarding resources and study strategies to share with program directors and future residen...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.07.026
更新日期:2015-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to test high temporal resolution dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). Determine whether the addition of ultrafast DCE-MRI improves the perform...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.10.004
更新日期:2018-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Mammographic breast density is an important and widely accepted risk factor for breast cancer. A statement about breast density in the mammographic report is becoming a requirement in many States. However, there is significant inter-observer variation between radiologists in their interpretatio...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.07.011
更新日期:2011-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of ordering an imaging test for headache, which is one of the most common reasons for patient consultation with a primary care physician (PCP), include medical indications as well as patient anxiety and medico-legal concerns. The impact of nonclinical factors on PCPs' ordering patte...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.03.050
更新日期:2004-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to present and evaluate a fully automated system for emphysema quantification on low-dose computed tomographic images. The platform standardizes emphysema measurements against changes in the reconstruction algorithm and slice thickness. MATERIALS AND METHODS:Emphysema...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.06.015
更新日期:2011-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Dual-energy computed tomography (DECT) and ultrasound are both used to assess gouty arthritis. The present study was designed to compare the diagnostic accuracy of DECT and ultrasound in detecting monosodium urate (MSU) crystal deposition in various joints. MATERIALS AND METHODS:This study enr...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.010
更新日期:2015-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study was performed to evaluate the feasibility of using a joystick-controlled robotic needle driver to place a 22-gauge needle for nerve and facet blocks. MATERIALS AND METHODS:Biplane fluoroscopy and a robotic needle driver were used to place 12 needles into the lumbar paraspinal region...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80356-2
更新日期:2002-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Diffusion tensor tractography (DTT) for neural fibers of the head-and-neck region at 3T has not been reported. The purpose of this study was to evaluate the feasibility of using DTT for visualizing neural fibers in the head-and-neck region at 3T and to explore the use of this method in patients...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.01.019
更新日期:2009-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Needle biopsy is currently the only way to confirm prostate cancer. To increase prostate cancer diagnostic rate, needles are expected to be deployed at suspicious cancer locations. High-contrast magnetic resonance (MR) imaging provides a powerful tool for detecting suspicious cancerous tissues....
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.07.018
更新日期:2007-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To analyze the statistical biases in the studies used to derive cardiac magnetic resonance-based major and minor criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). MATERIALS AND METHODS:ARVC is a rare disorder of the heart that can lead to sudden death in you...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.04.009
更新日期:2015-08-01 00:00:00
abstract::Quantitative imaging (QI) is increasingly applied in modern radiology practice, assisting in the clinical assessment of many patients and providing a source of biomarkers for a spectrum of diseases. QI is commonly used to inform patient diagnosis or prognosis, determine the choice of therapy, or monitor therapy respon...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2014.08.011
更新日期:2015-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To estimate the gain in signal-to-noise ratio (SNR) in first-pass contrast-enhanced (CE) abdominal magnetic resonance angiography (MRA) at 3.0 T compared with 1.5 T. MATERIALS AND METHODS:Three protocols were simulated using six contrast agents: gadopentetate dimeglumine (Magnevist, Berlex, Wa...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.03.007
更新日期:2007-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Lymphangiomatosis is a rare disease characterized by the widespread presence of lymphangiomas in any part of the body. In previous studies, lymphatic vessel abnormalities in lymphangiomatosis have only rarely been mentioned. The objective of this paper is to discuss the imaging features of lymp...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.03.024
更新日期:2020-02-01 00:00:00
abstract::The authors describe the establishment of a radiology residency research track at their institution. Based on growing biomedical technology needs and the tremendous increase in imaging-based research, the importance of training and cultivating future clinical investigators continues to grow. Within the framework of a ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.08.011
更新日期:2013-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate residents' knowledge of adverse effects of ionizing radiation, frequency of their education on radiation safety, and their use of radioprotective equipment. MATERIALS AND METHODS:Residents from 15/16 residency programs at Emory University were asked to complete a resident radiat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.01.016
更新日期:2014-07-01 00:00:00
abstract::The three missions of academic radiology compete with one another for time and funding. Revenue for the clinical mission often subsidizes education and research. Given the internal and external drivers/pressures on health care and, more particularly, on academic health centers, the current model is unsustainable. Tren...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2013.04.003
更新日期:2013-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluated two Bayesian regression models for receiver operating characteristic (ROC) curve analysis of continuous diagnostic outcome data with covariates. MATERIALS AND METHODS:Full and partial Bayesian regression models were applied to data from two studies (n = 180 and 100, respe...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80578-0
更新日期:2001-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Since the initial description of an intralobar attenuation gradient by Webb et al, it has been suggested that departure from the intralobar attenuation gradient could indicate early lung diseases. However, its significance has not been determined in detail. We aimed to quantify the anteroposter...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.10.025
更新日期:2006-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To describe the application of time maximum intensity projection CTA (t-MIP CTA) in acute ischemic stroke and compare t-MIP CTA and single-phase CTA (sCTA) in assessing collateral circulation and predicting prognosis. MATERIALS AND METHODS:Twenty-nine acute ischemic stroke patients who underwe...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.06.013
更新日期:2020-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Today, the exchange of medical images and clinical information is well defined by the digital imaging and communications in medicine (DICOM) and Health Level Seven (ie, HL7) standards. The interoperability among information systems is specified by the integration profiles of IHE (Integrating the...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.11.015
更新日期:2005-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Rotator cuff disorders are prevalent and can cause pain and reduced range of motion and strength. Accurate, noninvasive diagnosis of rotator cuff disorders is therefore important. In this work, we study the relationship between several three-dimensional (3D) shape measurements of the supraspina...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.06.014
更新日期:2007-10-01 00:00:00
abstract::Feedback is an essential component of education. It is designed to influence, reinforce, and change behaviors, concepts, and attitudes in learners. Although providing constructive feedback can be challenging, it is a learnable skill. The negative consequences of destructive feedback or lack of feedback all together ar...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.11.023
更新日期:2017-06-01 00:00:00