当前位置： SCI文献检索 > ACADEMIC RADIOLOGY期刊下所有文献 > Comparison of T1 Mapping and T1rho Values with Conventional Diffusion-weighted Imaging to Assess Fibrosis in a Rat Model of Unilateral Ureteral Obstruction.

Comparison of T1 Mapping and T1rho Values with Conventional Diffusion-weighted Imaging to Assess Fibrosis in a Rat Model of Unilateral Ureteral Obstruction.

Abstract：

RATIONALE AND OBJECTIVES:The aim of this study was to investigate the potential of magnetic resonance imaging (MRI) T1 mapping and T1 relaxation time in the rotating frame (T1rho) for assessment of renal fibrosis in a rat model of unilateral ureteral obstruction (UUO). MATERIALS AND METHODS:UUO was created in 36 rats. Six rats were scanned at each of the six time points (on days 0, 1, 3, 5, 10, and 15 after UUO). The contralateral kidneys were examined as controls. Hematoxylin-eosin, Masson's trichrome, and alpha-smooth muscle actin (α-SMA) antibody staining assays were performed. MRI data obtained with a 3.0T scanner were analyzed with α-SMA expression and Masson's staining. RESULTS:The T1 relaxation times and T1rho values increased, and the mean apparent diffusion coefficient (ADC) values decreased with time after UUO. Simple regression analysis indicated that the mean ADCs, T1 relaxation times, and T1rho values had strong correlations with the α-SMA expression levels (R2 = 0.34, R2 = 0.66, R2 = 0.71, respectively; P< .001) and positive Masson's staining (R2 = 0.38, R2 = 0.67, R2 = 0.65, respectively; P< .001). CONCLUSIONS:The T1 mapping and T1rho parameters had better correlations with α-SMA expression and Masson's staining than ADC values.

journal_name

Acad Radiol

journal_title

Academic radiology

authors

Hu G,Liang W,Wu M,Lai C,Mei Y,Li Y,Xu J,Luo L,Quan X

doi

10.1016/j.acra.2018.03.023

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

22-29

issue

1

eissn

1076-6332

issn

1878-4046

pii

S1076-6332(18)30136-3

journal_volume

26

pub_type

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