Abstract:
RATIONALE AND OBJECTIVE:Emphysema is characterized by airspace dilation, inflammation, and irregular deposition of elastin and collagen in the interstitium. Computed tomographic studies have reported that lung mass (LM) may be increased in smokers, a finding attributed to inflammatory and parenchymal remodeling processes observed on histopathology. We sought to examine the epidemiologic and clinical associations of LM in smokers. MATERIALS AND METHODS:Baseline epidemiologic, clinical, and computed tomography (CT) data (n = 8156) from smokers enrolled into the COPDGene Study were analyzed. LM was calculated from the CT scan. Changes in lung function at 5 years' follow-up were available from 1623 subjects. Regression analysis was performed to assess for associations of LM with forced expiratory volume in 1 second (FEV1) and FEV1 decline. RESULTS:Subjects with Global Initiative for Chronic Obstructive Lung Disease (GOLD) 1 chronic obstructive pulmonary disease had greater LM than either smokers with normal lung function or those with GOLD 2-4 chronic obstructive pulmonary disease (P < 0.001 for both comparisons). LM was predictive of the rate of the decline in FEV1 (decline per 100 g, -4.7 ± 1.7 mL/y, P = 0.006). CONCLUSIONS:Our cross-sectional data suggest the presence of a biphasic radiological remodeling process in smokers: the presence of such nonlinearity must be accounted for in longitudinal computed tomographic studies. Baseline LM predicts the decline in lung function.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Washko GR,Kinney GL,Ross JC,San José Estépar R,Han MK,Dransfield MT,Kim V,Hatabu H,Come CE,Bowler RP,Silverman EK,Crapo J,Lynch DA,Hokanson J,Diaz AA,COPDGene Investigators.doi
10.1016/j.acra.2016.10.011subject
Has Abstractpub_date
2017-04-01 00:00:00pages
386-392issue
4eissn
1076-6332issn
1878-4046pii
S1076-6332(16)30389-0journal_volume
24pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:To evaluate if incidental abdominopelvic calcified atherosclerosis (ACA) in patients under 50 years of age correlates with cardiovascular disease (CVD) risk factors. Most studies evaluating calcific atherosclerosis and associated increased risk of CVD have concentrated on middle age and older p...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.10.013
更新日期:2020-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Q-space analysis using high b-value diffusion-weighted magnetic resonance (MR) data provides information on tissue microstructure in contrast to conventional MR imaging (MRI) based on low b-value diffusion-weighted imaging (DWI). The purpose of this study was to evaluate the use of mean displac...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.005
更新日期:2011-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of ordering an imaging test for headache, which is one of the most common reasons for patient consultation with a primary care physician (PCP), include medical indications as well as patient anxiety and medico-legal concerns. The impact of nonclinical factors on PCPs' ordering patte...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.03.050
更新日期:2004-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Cellulitis is a common cause for emergency department (ED) presentation and subsequent hospital admission. Underlying fracture, osteomyelitis, or foreign body is often considered in the clinical evaluation of these patients. Accordingly, plain radiographs (XRs) of the affected extremity are oft...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.002
更新日期:2015-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to determine the acquisition and interpretation times of screen-film mammography and soft-copy digital mammography in a diagnostic mammography center. MATERIALS AND METHODS:The study was conducted in three phases for patients presenting for clinical diagnostic wor...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2010.04.018
更新日期:2010-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to determine the optimal arterial phase delay for computed tomography imaging of hepatocellular carcinoma (HCC) before and after transarterial chemoembolization (TACE) using a low iodine dose protocol. MATERIALS AND METHODS:A total of 39 patients with known HCC were i...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.021
更新日期:2015-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To determine the differences in the psychosocial effects and future mammography screening behavior between women who had an abnormal mammogram followed either by percutaneous or open surgical breast biopsy or cyst aspiration, or by short-term follow-up mammography to provide insight to radiolog...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00382-9
更新日期:2003-11-01 00:00:00
abstract::The three missions of academic radiology compete with one another for time and funding. Revenue for the clinical mission often subsidizes education and research. Given the internal and external drivers/pressures on health care and, more particularly, on academic health centers, the current model is unsustainable. Tren...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2013.04.003
更新日期:2013-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this report is to investigate the magnetic field dependence of the signal-to-noise ratio (SNR) for carotid vessel wall magnetic resonance imaging using phased-array (PA) surface coils by comparing images obtained at 1.5 and 3 Tesla (T) and determine the extent to which the improved S...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.08.009
更新日期:2005-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to compare different sequences for olfactory bulb volumetry using 3-T magnetic resonance imaging, evaluating reproducibility, repeatability, and systematic biases. MATERIALS AND METHODS:Twenty-two volunteers underwent 3-T magnetic resonance imaging of the frontal skul...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.018
更新日期:2011-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to compare magnetic resonance (MR) venography and conventional venography in the diagnosis of deep venous thrombosis (DVT) in the calf after sonography. MATERIALS AND METHODS:Sonography was performed in 595 patients who were suspected of having lower-extremity ...
journal_title:Academic radiology
pub_type: 临床试验,杂志文章
doi:10.1016/s1076-6332(03)80764-x
更新日期:2001-09-01 00:00:00
abstract:PURPOSE:To determine whether coronary artery anomalies can be detected on noncontrast computed tomography (CT) coronary artery calcium scoring (CCS) studies. MATERIALS AND METHODS:A total of 126 patients (mean age 62 years; 35 women) underwent noncontrast CCS and contrast enhanced coronary CT angiography (cCTA). Thirt...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.12.006
更新日期:2013-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Dual-energy computed tomography (DECT) and ultrasound are both used to assess gouty arthritis. The present study was designed to compare the diagnostic accuracy of DECT and ultrasound in detecting monosodium urate (MSU) crystal deposition in various joints. MATERIALS AND METHODS:This study enr...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2015.08.010
更新日期:2015-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Coronary CT angiography (CCTA) is a noninvasive reliable cardiovascular imaging technology to assess coronary atherosclerosis progression. However, there is limited data available to investigate the relationship between the atherosclerosis progression and cardiovascular events in patients with ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.06.038
更新日期:2020-10-22 00:00:00
abstract:RATIONALE AND OBJECTIVES:Balloon dilatation is a mechanical form of controlled injury used to alleviate vascular stenoses. Several factors influence successful angioplasty. Few mechanical models exist to illustrate the physical principles of balloon dilatation. METHODS:We used mechanical analysis of membrane stresses,...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80340-x
更新日期:1995-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Extraintestinal abnormalities visible without contrast material on abdominal radiographs are reported less frequently when contrast examinations are performed. Gaze dwell time was used to determine whether this difference is due to failure by observers to scan plain-film regions of contrast stu...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80271-6
更新日期:1996-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluated changes of lung attenuation in pigs, with special attention to the mosaic pattern of low attenuation, at thin-section computed tomography (CT) after obstruction of the proximal pulmonary artery with a detachable balloon. MATERIALS AND METHODS:In seven pigs, nine sites of ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(98)80241-9
更新日期:1998-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Efforts to decrease radiation exposure during pediatric high-resolution thoracic computed tomography (HRCT), while maintaining diagnostic image quality, are imperative. The objective of this investigation was to compare organ doses and scan performance for pediatric HRCT using volume, helical, ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2013.05.013
更新日期:2013-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to develop a computer-aided diagnosis (CAD) system in assessing the sonographic morphologic and texture features of soft-tissue tumors. MATERIALS AND METHODS:The retrospective study involved 114 pathology proven cases including 73 benign and 41 malignant soft-tissue t...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.07.024
更新日期:2009-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To retrospectively analyze the chest imaging findings in patients with coronavirus disease 2019 (COVID-19) on thin-section CT. MATERIALS AND METHODS:Fifty-three patients with confirmed COVID-19 infection underwent thin-section CT examination. Two chest radiologists independently evaluated the ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.03.002
更新日期:2020-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate changes in lung microstructure in healthy adult subjects with no smoking history using diffusion-weighted 3He MRI. MATERIALS AND METHODS:Diffusion magnetic resonance imaging using hyperpolarized helium 3 (3He) was applied to healthy volunteers to explore the dependence of lung m...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.08.005
更新日期:2005-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate residents' knowledge of adverse effects of ionizing radiation, frequency of their education on radiation safety, and their use of radioprotective equipment. MATERIALS AND METHODS:Residents from 15/16 residency programs at Emory University were asked to complete a resident radiat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.01.016
更新日期:2014-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors performed this study to determine the feasibility of using quantitative 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) to monitor the response of breast cancer bone metastases to therapy. MATERIALS AND METHODS:Twenty-four women with stage IV bone-d...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80461-0
更新日期:2002-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We investigated the influence of muscular activity and regional body temperature changes on the accumulation of intravenously (i.v.) administered, dextran-coated superparamagnetic iron oxide (SPIO) particles in the lymph nodes of rats. METHODS:Four groups of rats (N = 21) were used. Five rats ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80193-0
更新日期:1996-08-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors hypothesized that electrocardiographic triggering near end systole could minimize motion artifacts in electron-beam computed tomography (CT) of the coronary artery. MATERIALS AND METHODS:The study included 2,660 patients who underwent coronary artery calcium scanning with electron-...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/S1076-6332(03)80722-5
更新日期:2001-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We evaluated the effect of gravity on intrahepatic perfusion (IHP) in patients with a port-catheter system (PCS) implanted for hepatic arterial infusion chemotherapy (HAIC). Using fused single photon-emission computed tomographic (SPECT)/computed tomographic (CT) images, we compared IHP after t...
journal_title:Academic radiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.acra.2008.12.004
更新日期:2009-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Some deep pelvic abscesses are not accessible through anterior or lateral approaches because of the presence of organs and structures. The objective of this study was to assess the feasibility, safety, tolerability, and efficacy of a percutaneous presacral space approach by reviewing our clinic...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2016.06.009
更新日期:2016-12-01 00:00:00
abstract:PURPOSE:This investigation is part of a prospective National Institutes of Health-funded study evaluating three different methods for estimating the optimal length for placement of a new nasogastric (NG) tube. Abdomen radiographs were required to determine the location of the tube tip. Our objective was to analyze diff...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.02.007
更新日期:2012-06-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Nephrosclerosis occurs with aging and is characterized by increased kidney subcapsular surface irregularities at autopsy. Assessments of cortical roughness in vivo could provide an important measure of nephrosclerosis. The purpose of this study was to develop and validate an image-processing al...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.05.014
更新日期:2014-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Electronic learning (e-learning) may provide a means to enhance learning efficacy. However, introduction of e-learning often fails. We describe a strategy of how an e-learning curriculum was successfully implemented. MATERIALS AND METHODS:The curriculum was designed based on published evidence...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.12.006
更新日期:2006-03-01 00:00:00