Abstract：
RATIONALE AND OBJECTIVES:The purpose of this study was to describe a simple bootstrap approach for estimating sensitivity, specificity, and the area under the receiver operating characteristic curve for multisite test outcome data. MATERIALS AND METHODS:The performance of bootstrap estimates was evaluated and compared with that of analytic estimates by using a simulation study. Bootstrapping was demonstrated by using data from a previous study comparing two angiographic methods. RESULTS:Analytic and bootstrap estimates had similar coverage rates for 95% confidence intervals. With many sites per patient, bootstrap estimates had slightly better coverage than analytic estimates. Bootstrap percentile intervals had better coverage than asymptotic normal bootstrap intervals. CONCLUSION:Bootstrapping is a useful method of estimating confidence intervals for the area under the receiver operating characteristic curve, sensitivity, and specificity when data are correlated.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Rutter CMdoi
10.1016/s1076-6332(00)80381-5keywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
413-9issue
6eissn
1076-6332issn
1878-4046journal_volume
7pub_type
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journal_title：Academic radiology
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