Abstract:
RATIONALE AND OBJECTIVES:A number of studies have reported decreases in fractional anistropy (FA) in amyotrophic lateral sclerosis using diffusion tensor imaging (DTI). The purpose of this study was to perform a meta-analysis in order to estimate the diagnostic test accuracy measures of DTI for the diagnosis of amyotrophic lateral sclerosis (ALS). MATERIALS AND METHODS:We searched MEDLINE (1966-April 2011), EMBASE (1999-April 2011), CINAHL (1999-April 2011), and Cochrane (2005-April 2011) databases to identify studies that measured FA in ALS subjects. Human, single-center studies using a DTI region of interest (ROI) or tractography techniques were used to compare FA values along the brain corticospinal tracts between ALS subjects and healthy controls. There were no language restrictions. Independent extraction of articles by 2 authors using predefined data fields including study quality indicators. We identified 30 case-control studies that used region of interest or tractography DTI techniques. We applied binormal receiver operative characteristic (ROC) curve analysis to assign specificity and sensitivity for each study. We applied the bivariate mixed-effects regression model using the Markov Chain Monte Carlo Simulation to calculate summary estimates for the sensitivity and specificity. We used the metan module in Stata, version 11.0, to calculate the area under the ROC curve, diagnostic odds ratio and the test effectiveness summary estimates. RESULTS:The pooled sensitivity was 0.65 (95% CI 0.61-0.69); the pooled specificity, 0.67 (95% CI 0.63-0.72); the pooled diagnostic odds ratio, 1.88 (95% CI 1.46-2.30); the pooled test effectiveness, 1.04 (95% CI 0.81-1.27); and the pooled area under the ROC curve, 0.76 (95% CI 0.71-0.81). Subanalyses comparing magnetic resonance imaging (MRI) field strength (1.5T vs. 3.0T) and brain location (corticospinal tract average vs. internal capsule) revealed no significant differences in the test accuracy measures. Reference standard used for the diagnosis of ALS was the El Escorial criteria. There was at least moderate heterogeneity between the studies. True study quality is uncertain. CONCLUSION:The discriminatory capability of DTI to make a diagnosis of ALS is only modest. There were no significant differences in the diagnostic test accuracy summary estimates with respect to MRI field strength or brain location.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Foerster BR,Dwamena BA,Petrou M,Carlos RC,Callaghan BC,Pomper MGdoi
10.1016/j.acra.2012.04.012subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1075-86issue
9eissn
1076-6332issn
1878-4046pii
S1076-6332(12)00232-2journal_volume
19pub_type
杂志文章,meta分析abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to develop and test new assistive devices to aid in the performance of safe, easy, and accurate microwave thermocoagulation therapy guided by magnetic resonance (MR) imaging. MATERIALS AND METHODS:An open-configuration MR imager with an optical tracking system for...
journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors' purpose was to search the inversion time (TI) values that enable the best differentiation of fine structures in gray matter (gray-gray differentiation). MATERIALS AND METHODS:Seven healthy adult volunteers with no history of neurologic disease or head trauma were recruited and gav...
journal_title:Academic radiology
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abstract:RATIONALE AND OBJECTIVES:To quantify the use of Diagnostic Certainty Phrases (DCP) in radiology reports, including DCPs with good agreement (including "diagnostic of," "unlikely" and "represents") in connoting degree of certainty between providers based on previous studies; and to assess whether modality, presence of a...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.10.017
更新日期:2019-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Coronary CT angiography (CCTA) is a noninvasive reliable cardiovascular imaging technology to assess coronary atherosclerosis progression. However, there is limited data available to investigate the relationship between the atherosclerosis progression and cardiovascular events in patients with ...
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abstract:RATIONALE AND OBJECTIVES:Engaging medical students during a radiology course can be challenging. We sought a way to actively engage students with live cases, allow them to interact with the picture archiving and communication system workstation, and experience what it is like to be a radiologist. MATERIALS AND METHODS...
journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to determine whether uterine leiomyoma can be distinguished from uterine leiomyosarcoma on ultrasound (US), computed tomography (CT), and/or magnetic resonance imaging (MRI) without diffusion-weighted imaging. MATERIALS AND METHODS:Institutional review board approval was obtai...
journal_title:Academic radiology
pub_type: 杂志文章
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abstract:RATIONALE AND OBJECTIVES:The aim of this study was to develop a pulmonary nodule viewing system to visualize and retrieve data from the Lung Image Database Consortium. MATERIALS AND METHODS:The pulmonary nodule viewing system, developed using Microsoft C++ and the .NET 2.0 Framework, is composed of a clinical informat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.04.006
更新日期:2011-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Magnetic resonance (MR) imaging is used to assess brain tumor response to therapies, and a MR quality assurance (QA) program is necessary for multicenter clinical trials employing imaging. This study was performed to determine overall variability of quantitative imaging metrics measured with th...
journal_title:Academic radiology
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acra.2008.04.004
更新日期:2008-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study was performed to determine physical characteristics of areas on chest radiographs that are suspicious but not definitive for the presence of a pulmonary nodule and the characteristics of areas that contain an obvious nodule. MATERIALS AND METHODS:Two groups of patients were identifi...
journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:1998-09-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2016-03-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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更新日期:2020-10-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
abstract::Breast density has been shown to be a strong, independent risk factor for breast cancer. Unfortunately, mammography is less accurate on dense breast tissue compared to fattier breast tissue. Multiple studies suggest a solution to this by demonstrating the ability of supplemental screening ultrasound to detect addition...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2016.05.017
更新日期:2016-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Studies of medical school clerkship websites have reported efficient time management, resource utilization, and hands-on activities. We built a website devoted to medical student education in radiology to address student, educator, and school curricular needs and surveyed students to assess the...
journal_title:Academic radiology
pub_type: 杂志文章
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:1998-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To analyze the statistical biases in the studies used to derive cardiac magnetic resonance-based major and minor criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). MATERIALS AND METHODS:ARVC is a rare disorder of the heart that can lead to sudden death in you...
journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2015-08-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.05.018
更新日期:2007-09-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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abstract:RATIONALE AND OBJECTIVES:To assess the diagnostic performance of magnetic resonance imaging (MRI) for targeting prostate cancer in patients with previous negative biopsies and elevated prostate-specific antigen (PSA) levels. MATERIALS AND METHODS:Pubmed, Scopus, and Cochrane Library databases were searched to identify...
journal_title:Academic radiology
pub_type: 杂志文章,meta分析,评审
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journal_title:Academic radiology
pub_type: 杂志文章
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更新日期:2009-06-01 00:00:00
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journal_title:Academic radiology
pub_type: 杂志文章
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abstract:RATIONALE AND OBJECTIVES:Although inflammatory breast carcinoma (IBC) accounts for 1%-4% of all breast cancer cases, the appearance of this highly malignant tumor in magnetic resonance imaging (MRI) is still not well characterized. The aim of this study was to identify typical imaging features of IBC in comparison with...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.09.011
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