Abstract:
RATIONALE AND OBJECTIVES:The aim of this study was to investigate the effects of exogenous endothelial progenitor cells (EPCs) on the growth and invasiveness of glioma in vivo to provide an experimental basis for the value and safety of using magnetically labeled EPCs as target vectors to detect early infiltration of glioma. MATERIALS AND METHODS:EPCs were collected from the spleens of healthy Sprague-Dawley rats, made EPCs conditioned medium after identification. Four models of Sprague-Dawley rat glioma (60 rats in total) were established as a control and three experimental groups (group A, B, and C). In the control group, orthotopic transplantation of C6 glioma cells was performed. Compared to the control group, EPCs conditioned medium was added in group A and P7228-labeled EPCs were added in group B. In group C, P7228-labeled EPCs were transplanted via the tail vein. Magnetic resonance imaging and perfusion-weighted imaging were performed on several days. Tumor microvascular density and vascular endothelial growth factor expression were determined through immunohistochemistry. RESULTS:In group C, hypointense areas were detected at the periphery of the tumor on the first day after transplantation of EPCs, and more hypointense areas were found inside the tumor over time. Tumor size in all four groups developed significantly with increasing time (P < .01), but there was no marked difference among these groups at the same time (P > .05). No remarkable differences in microvascular density and cells positive for vascular endothelial growth factor were found at the same time among the four groups (P > .05). CONCLUSIONS:Both magnetic resonance imaging and immunohistochemical findings confirmed that exogenous EPCs could not affect the biologic behavior of C6 glioma cells in vivo through a paracrine effect or by direct cellular interaction. Therefore, exogenous EPCs could not exert significant promoting effects on glioma growth.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Fang J,Wang S,Chen J,Zhang Y,Zhang B,Liang H,Zhang Wdoi
10.1016/j.acra.2011.02.017subject
Has Abstractpub_date
2011-07-01 00:00:00pages
892-901issue
7eissn
1076-6332issn
1878-4046pii
S1076-6332(11)00155-3journal_volume
18pub_type
杂志文章abstract:RATIONALE AND OBJECTIVES:To investigate the correlation between prevalence and degree of coronary artery calcification (CAC) and extracoronary calcifications (ECCs), scored quantitatively according to Agatston and semiquantitatively by visual analysis, in chest computed tomography (CT) studies obtained for lung cancer ...
journal_title:Academic radiology
pub_type: 杂志文章,评审
doi:10.1016/j.acra.2015.03.005
更新日期:2015-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to investigate the effect of perfusion computed tomography (PCT) with acetazolamide (ACZ) challenge and compare it to 10% carbon dioxide (CO(2)) challenge in rat C6 glioma. MATERIALS AND METHODS:PCT was performed on 32 rats, including 20 with orthotopically implanted ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.09.017
更新日期:2012-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:A method is presented to track guide wires during endovascular interventions under X-ray fluoroscopy. Accurate guide wire tracking can be used to improve guide wire visualization in the low quality fluoroscopic images, and to estimate the position of the guide wire in world coordinates for navi...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)00539-7
更新日期:2003-12-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Radiology faces a severe and growing shortage of radiologic technologists. One way of redressing this problem is to improve the quality of education provided to radiologic technology students. Yet growing clinical demands increasingly erode faculty time for teaching. This study examined whether ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(03)80029-6
更新日期:2003-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Current approaches to receiver operating characteristic (ROC) analysis use the MRMC (multiple-reader, multiple-case) paradigm in which several readers read each case and their ratings (or scores) are used to construct an estimate of the area under the ROC curve or some other ROC-related paramet...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.07.016
更新日期:2006-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Distinguishing recurrent glial tumor from radiation necrosis can be challenging. The purpose of this pilot study was to preliminarily compare unenhanced arterial spin-labeled (ASL) imaging, dynamic susceptibility contrast-enhanced cerebral blood volume (DSCE-CBV) magnetic resonance imaging, and...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2009.10.024
更新日期:2010-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors evaluated the coordination of swallowing and respiration in dysphagic patients. MATERIALS AND METHODS:Video fluoroscopy and respirometry were performed simultaneously during 98 swallows in 33 patients (18 women, 15 men) with a median age of 70 years (interquartile range, 52-78 year...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80237-1
更新日期:1997-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Four-dimensional (4D) computed tomography (CT) can be used in radiation treatment planning to account for respiratory motion. Current 4D CT techniques have limitations in either spatial or temporal resolution. In addition, most of these techniques rely on auxiliary surrogates to relate the time...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.05.004
更新日期:2006-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this study was to test the effectiveness of resident-prepared, independent learning cases in teaching residents chest radiology. MATERIALS AND METHODS:Three 2nd-year residents (one each from the University of Wisconsin, the Oregon Health Sciences University, and the University o...
journal_title:Academic radiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s1076-6332(99)80059-2
更新日期:1999-01-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To investigate residents' knowledge of adverse effects of ionizing radiation, frequency of their education on radiation safety, and their use of radioprotective equipment. MATERIALS AND METHODS:Residents from 15/16 residency programs at Emory University were asked to complete a resident radiat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2014.01.016
更新日期:2014-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study aimed to test high temporal resolution dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). Determine whether the addition of ultrafast DCE-MRI improves the perform...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.10.004
更新日期:2018-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:To document the frequency of normal and anomalous drainage patterns of the pulmonary veins, and to establish normal values for pulmonary vein ostial diameters, and distance to first bifurcation using multidetector computed tomography, as pertinent to ablation procedures for atrial fibrillation....
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2006.11.004
更新日期:2007-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVE:Today, the exchange of medical images and clinical information is well defined by the digital imaging and communications in medicine (DICOM) and Health Level Seven (ie, HL7) standards. The interoperability among information systems is specified by the integration profiles of IHE (Integrating the...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2004.11.015
更新日期:2005-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:This study's aims were to depict changes in cartilage quality after surgical intervention using magnetic resonance (MR) examination and in content of glycosaminoglycans chains (GAGs) after two types of surgeries - chondral defect treatment by microfractures and scaffold implantation in combinat...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2020.05.030
更新日期:2020-06-30 00:00:00
abstract:RATIONALE AND OBJECTIVES:Extraprostatic extension of disease (EPE) has a major role in risk stratification of prostate cancer patients. Currently, pretreatment local staging is performed with MRI, while the gold standard is represented by histopathological analysis after radical prostatectomy. Texture analysis (TA) is ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2018.12.025
更新日期:2019-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Because it is imperative for understanding the performance of dual-energy computed tomography scanner to determine clinical diagnosis, we aimed to assess the accuracy of quantitative measurements using dual-energy computed tomography with fast kilovoltage switching. MATERIALS AND METHODS:Quant...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.11.002
更新日期:2018-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:We systematically characterized the information provided by chest radiography reports on a nationally representative sample of 822 elderly patients hospitalized in 297 acute-care hospitals in five states who had an admission diagnosis of congestive heart failure, acute myocardial infarction, or...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(96)80407-7
更新日期:1996-09-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Intravenous thrombolysis decision-making and obtaining of consent would be assisted by an individualized risk-benefit ratio. Deep learning (DL) models may be able to assist with this patient selection. MATERIALS AND METHODS:Clinical data regarding consecutive patients who received intravenous ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2019.03.015
更新日期:2020-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:In our earlier studies, we reported an evidence-based computer-assisted decision (CAD) system for location-specific interrogation of mammograms. A content-based image retrieval framework with information theoretic (IT) similarity measures serves as the foundation for this system. Specifically, ...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2007.12.013
更新日期:2008-05-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Inguinal lymph nodes can be the first or the only clinical signs of tumor metastases. The aim of the study was to evaluate the role of contrast-enhanced high-resolution magnetic resonance (MR) lymphangiography in diagnosis of inguinal lymph node metastases. MATERIALS AND METHODS:The study enro...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.09.014
更新日期:2013-02-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Malignancy provokes regional changes to vessel shape. Characteristic vessel tortuosity abnormalities appear early during tumor development, affect initially healthy vessels, spread beyond the confines of tumor margins, and do not simply mirror tissue perfusion. The ability to detect and quantif...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2005.05.027
更新日期:2005-10-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:Despite recent advances in the treatment of high-grade gliomas, overall survival (OS) remains poor, which underlines the importance of searching for and determining prognostic imaging biomarkers. The purpose of our retrospective study was to correlate patient survival with relative cerebral blo...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.11.011
更新日期:2013-04-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to compare the performance of various image-based metrics computed from thoracic high-resolution computed tomography (HRCT) with data from pulmonary function testing (PFT) in characterizing interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2012.03.007
更新日期:2012-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The addition of digital breast tomosynthesis (DBT) to digital screening mammography (DM) has been shown to decrease recall rates and improve cancer detection rates, but there is a lack of data regarding the impact of DBT on rates of short-term follow-up. We assessed possible changes in performa...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2016.10.001
更新日期:2017-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The study aimed to determine if intrathoracic fat volumes are associated with the presence and severity of systemic sclerosis (SSc), defined by the presence of pulmonary arterial hypertension (PAH). MATERIALS AND METHODS:A total of 265 patients were included in the study, 202 of whom had SSc (...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2017.07.003
更新日期:2017-12-01 00:00:00
abstract::The National Cancer Institute organized a workshop entitled "Image Archive Management" that was presented on August 28 and 29, 2000, at the Natcher Conference Center on the National Institutes of Health (NIH) campus. The purpose of this workshop was to solicit expert input for the planned development of an archival sy...
journal_title:Academic radiology
pub_type:
doi:10.1016/S1076-6332(03)80699-2
更新日期:2001-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:When pituitary adenoma, craniopharyngioma, and Rathke's cleft cyst grow in the sellar and suprasellar region, it is often difficult to differentiate among these three lesions on magnetic resonance (MR) images. The purpose of this study was to apply an artificial neural network (ANN) for differe...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2008.09.015
更新日期:2009-03-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The aim of this study was to compare different sequences for olfactory bulb volumetry using 3-T magnetic resonance imaging, evaluating reproducibility, repeatability, and systematic biases. MATERIALS AND METHODS:Twenty-two volunteers underwent 3-T magnetic resonance imaging of the frontal skul...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/j.acra.2011.02.018
更新日期:2011-07-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The purpose of this prospective randomized study was to compare the long-term instructional effectiveness of a computer-based radiology multimedia textbook (MMTB) with that of a traditional lecture. METHODS:Volunteer faculty/fellows and residents were randomly assigned to either a computer-bas...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(05)80731-7
更新日期:1994-11-01 00:00:00
abstract:RATIONALE AND OBJECTIVES:The authors studied the role of the endothelium and associated endothelial pathways in contrast material-induced renal vasoconstriction. MATERIALS AND METHODS:Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine an...
journal_title:Academic radiology
pub_type: 杂志文章
doi:10.1016/s1076-6332(97)80254-1
更新日期:1997-12-01 00:00:00