Abstract:
RATIONALE AND OBJECTIVES:The authors studied the role of the endothelium and associated endothelial pathways in contrast material-induced renal vasoconstriction. MATERIALS AND METHODS:Isometric contractions in human and rabbit renal artery rings with intact and denuded endothelium were stimulated with phenylephrine and increasing concentrations of the ionic contrast material diatrizoate, the nonionic contrast materials iopamidol and iomeprol, and the dimeric contrast material iodixanol in a tissue perfusion bath. Rings with intact endothelium were incubated with endothelium-stimulating compounds such as the NO synthetase inhibitor Ng nitro-L-arginine methyl ester (L-NAME) to study the endothelium-mediated vasomotor regulation and the NO-liberating substances molsidomine (SIN-1) and nitroprusside (NPR) to study the endothelial-mediated vasorelaxation before being stimulated with contrast material. RESULTS:Contrast material-induced, dose-dependent, reversible renal artery contractions are dependent on the type of contrast material. No differences in the contractions were found between intact and denuded rings. L-NAME had no effect on contrast material-induced contractions. Contractions were inhibited by the NO donors SIN-1 and NPR. SIN-1 was the most potent inhibitor. CONCLUSION:Contrast material-induced renal vasoconstriction is endothelium-independent. Selective pharmacologic stimulation of the endothelium by NO donors, however, may still be useful in the prophylaxis of contrast material-induced renal vasoconstriction and, thus, potentially nephrotoxicity.
journal_name
Acad Radioljournal_title
Academic radiologyauthors
Drescher P,Madsen POdoi
10.1016/s1076-6332(97)80254-1subject
Has Abstractpub_date
1997-12-01 00:00:00pages
788-94issue
12eissn
1076-6332issn
1878-4046journal_volume
4pub_type
杂志文章abstract::Radiology articles are primarily designed to be read on paper or a screen. Audio versions let users hear this material during activities when reading is not practical. Currently, there are relatively few radiology materials in audio format. However, inexpensive text-to-speech software can easily produce spoken-word ve...
journal_title:Academic radiology
pub_type: 杂志文章
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