Abstract:
BACKGROUND:Presence of severe autonomic failure (SAF), defined as coincidence of abnormal heart rate turbulence and abnormal deceleration capacity, identifies a group of patients with very poor prognosis among post-infarction patients with diabetes mellitus. However, factors contributing to development of SAF are entirely unknown. Here, we aimed to identify clinical, biochemical, and hemodynamic factors predicting SAF in a consecutive cohort of diabetic patients with coronary artery disease (CAD). METHODS:Between January 2010 and July 2011, we prospectively enrolled 97 patients with insulin-dependent type 2 diabetes mellitus and stable CAD in sinus rhythm. Heart rate turbulence (as marker of autonomic reflex activity) and deceleration capacity (as marker of autonomic tonic activity) were calculated from 24-hour Holter recordings. Uni- and multivariable logistic regression analysis included duration of diabetes mellitus, diabetic neuropathy, retinopathy, nephropathy, level of HbA(1c), left ventricular ejection fraction (LVEF), brain natriuretic peptide, presence of multivessel disease, and history of myocardial infarction. RESULTS:Ten (10.3%) of the 97 patients exhibited signs of SAF. Patients with SAF were characterized by longer duration of diabetes (25 years vs 15 years), higher prevalence of diabetic neuropathy (70% vs. 36%), retinopathy (80% vs 45%) and nephropathy (90% vs 55%), significantly higher levels of HbA(1c) (9.0% vs 7.4%; P = .002) and a lower LVEF (30% vs.55%; P = .001). On multivariable analysis, LVEF ≤ 35% and HbA(1c) >8% were the only factors which were independently associated with SAF (odds ratios of 23.1 [95% CI, 1.8-287.0]; P = .015 and 6.6 [1.1-40.1]; P = .043). DISCUSSION:In patients with insulin-dependent type 2 diabetes mellitus and CAD, presence of SAF correlates with both glycemic control and diabetic complications. Impaired LVEF and increased level of HbA(1c) were independently associated with SAF.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Zuern CS,Rizas K,Eick C,Sterz K,Gawaz M,Bauer Adoi
10.1016/j.jelectrocard.2012.07.010subject
Has Abstractpub_date
2012-11-01 00:00:00pages
774-9issue
6eissn
0022-0736issn
1532-8430pii
S0022-0736(12)00238-5journal_volume
45pub_type
杂志文章abstract::In a patient with the sick sinus syndrome and near syncope a prolonged sinus pause was documented and reproduced thereafter during sustained deep inspiration. Administration of intravenous atropine abolished this phenomenon, most probably indicating a hyperresponsiveness of the sinus node and AV junction to a vagotoni...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(86)80012-7
更新日期:1986-01-01 00:00:00
abstract::Postoperative atrial fibrillation is common after cardiac surgery. Prediction of which patients will develop postoperative atrial fibrillation would be clinically useful. Increased P-wave duration, suggesting atrial conduction delay and measured from preoperative electrocardiograms, predicts postoperative atrial fibri...
journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jelectrocard.2004.01.003
更新日期:2004-04-01 00:00:00
abstract::Computer analysis of electrocardiograms (ECGs) provides a large amount of ECG measurement data, which may be used for diagnostic classification and storage in ECG databases. Until now, neither error limits for ECG measurements have been specified nor has their influence on diagnostic statements been systematically inv...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(96)80022-7
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Several studies have documented the prognostic significance of the signal-averaged electrocardiogram (SAECG) both after myocardial infarction and nonischemic cardiomyopathy. However, whether the SAECG can identify patients with implantable cardioverter-defibrillator (ICD) who receive appropriate therapy has ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2005.08.009
更新日期:2006-04-01 00:00:00
abstract::Many electrocardiographic criteria have been proposed for the differentiation of ventricular extrasystole and supraventricular conduction with aberrancy in atrial fibrillation but the validity of these have not been confirmed by intracardiac studies. We recorded His bundle electrograms in nineteen patients (eleven men...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(85)80033-9
更新日期:1985-01-01 00:00:00
abstract::Extensive experience has been obtained with Medtronic pacemakers, in Glasgow where over 400 patients have received their primary implant. In this review, which covers a period of seven and a half years ending December 31, 1973, the technical reliability of electrode-leads is considered in terms of failed implant lifet...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(75)80030-6
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:Brugada syndrome (BrS) is an inherited ion channelopathy that may predispose affected individuals to atrial cardiomyopathy. We tested the hypothesis that BrS patients have higher degrees of atrial electrophysiological abnormalities compared to controls, and these can be reflected by changes in P-wave paramet...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.05.005
更新日期:2019-01-01 00:00:00
abstract::Isolated occlusion of the septal perforating branch of the left anterior descending coronary artery is extremely rare. As a result, little is known about its electrocardiographic manifestations compared with those of an anteroseptal myocardial infarction. We present the case of an isolated septal myocardial infarction...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2011.07.013
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) is a leading cause of death and disability. Conventional non-invasive diagnostic modalities for the detection of stable CAD at rest are subject to significant limitations: low sensitivity, and personal expertise. We aimed to develop a reliable and time-cost efficient screening t...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.12.018
更新日期:2020-01-01 00:00:00
abstract::An academic 12-lead electrocardiogram (ECG) core laboratory aims to provide the highest possible quality ECG recording, measurement, and storage to aid clinicians in research into important cardiovascular outcomes and to maximize the credibility of scientific results based solely, or in part, on ECG data. This positio...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1054/jelc.2001.22028
更新日期:2001-01-01 00:00:00
abstract::The paper electrocardiogram (ECG) has been widely used for cardiac assessment for well over a century. ECGs can be obtained quickly and cheaply. For this reason, an ever-growing amount of paper ECG records continue to accumulate, some of which are stored into a paper-only format. Converting paper ECGs into digital for...
journal_title:Journal of electrocardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jelectrocard.2016.09.007
更新日期:2017-01-01 00:00:00
abstract::Pulmonary vein isolation (PVI) using cryoballoon (CB) technique and cavotricuspid isthmus (CTI) ablation using radiofrequency (RF) are established interventions for drug-resistant atrial fibrillation (AF) and typical atrial flutter (AFL). Twelve patients with a mean age of 62 ± 12 years underwent simultaneous delivery...
journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.jelectrocard.2015.03.013
更新日期:2015-07-01 00:00:00
abstract::Precise recording of the standard 12-lead electrocardiogram (ECG) is technically time consuming. Placing limb leads on the torso has the major advantages of ease of use, increased speed of application, and decreased artifact. This modified ECG frequently substitutes for the standard 12-lead ECG in intensive care units...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2007.11.004
更新日期:2008-05-01 00:00:00
abstract::The myocardial electrical conduction is significantly influenced by the sympathetic and parasympathetic nervous systems. Hypervagotonia refers to increased vagal tone leading to sinus bradycardia, sinus pause, or any degree of atrioventricular (AV) block. There are many clinical, electrocardiographic, and electrophysi...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2009.07.018
更新日期:2009-11-01 00:00:00
abstract::The purpose of the present study is to assess QT-interval measurements from the EASI 12-lead electrocardiogram (ECG) as compared with the standard 12-lead ECG. The QT interval was automatically determined in simultaneously recorded standard and EASI 12-lead ECGs, using a validated wavelet-based delineator. The agreeme...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2006.08.089
更新日期:2007-04-01 00:00:00
abstract::In patients presenting with signs and symptoms of an acute coronary syndrome (ACS) the combination of multilead ST depression and ST elevation in lead aVR, the electrocardiographic "aVR sign," has been associated with severe left main coronary artery stenosis or diffuse coronary artery disease and a high risk of death...
journal_title:Journal of electrocardiology
pub_type: 杂志文章,评审
doi:10.1016/j.jelectrocard.2019.07.014
更新日期:2019-01-01 00:00:00
abstract::The vectorcardiographic basis of indeterminate QRS axis has not been elucidated. Accordingly, Frank lead VCGs were obtained on ten consecutive subjects with biphasic QRS complexes in the six extremity leads. The frontal plane vector in each case showed a very narrow loop inscribed in a symmetrical fashion around the E...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(82)80022-8
更新日期:1982-01-01 00:00:00
abstract::Thoracic electromaps were recorded before and after sublingual nitroglycerin (NG) in 26 subjects 15 and 30 days after acute myocardial infarction (MI), in order to evaluate the effect of the drug on injury potentials. Ten patients with documented left ventricular aneurysm were also studied 5 to 46 months after acute M...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(81)81007-2
更新日期:1981-10-01 00:00:00
abstract::The authors investigated 244 consecutive patients with suspected coronary artery disease by coronary angiography and quantitative left ventriculography to compare the Minnesota Q/QS code (MC) with clinical electrocardiographic (ECG) interpretation. Patients who were suspected to have wall motion abnormalities for reas...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(93)90006-y
更新日期:1993-04-01 00:00:00
abstract::The electrocardiographic criteria for isolated left anterior fascicular block are reviewed and illustrated. Left anterior fascicular block decreases the voltage in the chest leads and increases the voltage in the limb leads. The usual voltage criteria of left ventricular hypertrophy must be modified appropriately. Cha...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(83)80024-7
更新日期:1983-04-01 00:00:00
abstract::The electrocardiographic transient display of left ventricular hypertrophy (LVH), during rapid heart rates, in the setting of sinus/supraventricular tachycardias and atrial fibrillation, is illustrated via 3 case reports. This common occurrence is expressed by an increase in the S-waves in leads V2-V5, during tachycar...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2021.01.001
更新日期:2021-01-09 00:00:00
abstract:BACKGROUND:Cardiac magnetic resonance (CMR) is currently considered the reference standard for in vivo assessment of myocardial infarction (MI). There is, however, no international consensus on how MI quantification from CMR should be performed. The aim of this study was to test how previously published manual quantifi...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2011.06.007
更新日期:2011-09-01 00:00:00
abstract::In treating atrial fibrillation (AF) the goal of ventricular rate reduction is still not determined. An animal model of AF was developed in which the relationship between ventricular rate and the parameters of cardiac function in AF can be studied. To simulate AF, complete heart block was chemically produced on open-c...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(05)80100-1
更新日期:1994-04-01 00:00:00
abstract::Serial electrocardiograms (ECGs) of 49 patients receiving adriamycin were analyzed for the development of persistent changes. The ECG changes were compared with those of a control group of 20 patients receiving other chemotherapeutic drugs, which were comparable to the additional chemotherapy received by the adriamyci...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(78)80122-8
更新日期:1978-07-01 00:00:00
abstract::Body surface isopotential maps around early ventricular activation were investigated in 30 normal subjects by the use of the authors' signal-averaged body surface mapping system. The number of beats averaged was 96-154 (mean, 127). Two distinct patterns were recognized in the appearance of a maximum at the onset of ve...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(91)90025-h
更新日期:1991-07-01 00:00:00
abstract::This contribution discusses the dominant T wave, a concept providing an overall view on the repolarization currents of the ventricular myocardium. The dominant T wave is a weighted mean of the T waves on the body surface. It can be estimated from the matrix of sampled observed potentials. The timing of its peak reveal...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2004.08.056
更新日期:2004-01-01 00:00:00
abstract::The Electrocardiogram has extensively been used for evaluation and triage of patients with acute chest pain. The clinician admitting a patient with ST elevation acute myocardial infarction should be able to estimate the size and location of the ischemic area at risk, how much of the ischemic myocardium has already und...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2005.01.003
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The prevalence and determinants of QRS transition zones are not well established. METHODS:We examined the distributions of Normal, clockwise (CW) and counterclockwise (CCW)) QRS transition zones and their relations to disease, body size and demographics in 4624 black and white men and women free of cardiova...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2017.10.004
更新日期:2018-01-01 00:00:00
abstract::The widespread clinical application of implantable electrical defibrillation devices has engendered considerable interest into the mechanism of action of such devices. In addition, better means of rapid detection of postshock efficacy have been sought. The authors performed this study to test the following hypotheses:...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(90)90073-b
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Periodic repolarization dynamics (PRD) refers to low-frequency oscillations of cardiac repolarization, most likely related to phasic sympathetic activation. Increased PRD is a validated predictor of mortality after myocardial infarction and in ischemic heart disease, but has not been tested in aortic valve s...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2017.08.004
更新日期:2017-01-01 00:00:00