Abstract:
BACKGROUND:Brugada syndrome (BrS) is an inherited ion channelopathy that may predispose affected individuals to atrial cardiomyopathy. We tested the hypothesis that BrS patients have higher degrees of atrial electrophysiological abnormalities compared to controls, and these can be reflected by changes in P-wave parameters determined on the electrocardiogram (ECG). METHODS:This was a single-center retrospective study comparing BrS patients to age- and gender-matched control subjects. Mean P-wave duration (PWDmean), maximum PWD (PWDmax) and minimum PWD (PWDmin), P-wave dispersion (PWDmax - PWDmin), and P-wave terminal force in V1 (PTFV1) were measured. PWDmax ≥ 120 ms, in the presence and absence of biphasic P-waves in the inferior leads, were termed advanced and partial inter-atrial block (IAB), respectively. RESULTS:The proportion of IAB was significantly higher in BrS patients (28/51; 55%) than in control subjects (14/51; 27%; Fisher's Exact test; P < 0.01). Advanced IAB was observed in two BrS patients but none of the control subjects (P = 0.50). Compared to controls, BrS patients showed higher PWDmean (107 [98-113] vs. 97 [90-108] ms; KWANOVA, P < 0.01), PWDmax (123 [110-132] vs. 113 [107-121] ms; P < 0.001) but statistically indistinguishable PWDmin (82 [72-92] vs. 77 [69-85]; P = 0.09), and P-wave dispersion (38 [26-52] vs. 37 [23-45] ms; P = 0.14). PTFV1 was significantly higher in BrS patients than in control subjects (24 [0-40] vs. 0 [0-27] mm.ms; P < 0.05). CONCLUSION:Atrial conduction abnormalities are frequently observed in BrS. These patients may require monitoring for future development of atrial fibrillation and stroke.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Tse G,Reddy S,Chopra J,Lee S,Liu T,Bazoukis G,Haseeb S,Lee APW,Letsas KP,Li KHCdoi
10.1016/j.jelectrocard.2019.05.005subject
Has Abstractpub_date
2019-01-01 00:00:00pages
102-106eissn
0022-0736issn
1532-8430pii
S0022-0736(19)30118-9journal_volume
55pub_type
杂志文章abstract:BACKGROUND AND PURPOSE:Descriptions of the significance of ST segment or QRS abnormalities in myocarditis are limited because documentation of the diagnosis has previously required myocardial biopsy. Late gadolinium enhancement (LGE) and T2 weighted imaging in the midventricular wall on cardiac magnetic resonance imagi...
journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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pub_type: 杂志文章,随机对照试验
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journal_title:Journal of electrocardiology
pub_type: 杂志文章,评审
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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pub_type: 杂志文章
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更新日期:2001-04-01 00:00:00
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
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journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2006.09.001
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journal_title:Journal of electrocardiology
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journal_title:Journal of electrocardiology
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pub_type: 杂志文章
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abstract:BACKGROUND:Reducing time to reperfusion treatment for patients with ST-segment elevation myocardial infarction (STEMI) improves patient outcomes. Few medical systems consistently meet current benchmarks regarding timely access to treatment. Studies have widely demonstrated that prehospital 12-lead electrocardiography c...
journal_title:Journal of electrocardiology
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