Abstract:
BACKGROUND:Coronary artery disease (CAD) is a leading cause of death and disability. Conventional non-invasive diagnostic modalities for the detection of stable CAD at rest are subject to significant limitations: low sensitivity, and personal expertise. We aimed to develop a reliable and time-cost efficient screening tool for the detection of coronary ischemia using machine learning. METHODS:We developed a supervised artificial intelligence algorithm combined with a five lead vectorcardiography (VCG) approach (i.e. Cardisiography, CSG) for the diagnosis of CAD. Using vectorcardiography, the excitation process of the heart can be described as a three-dimensional signal. A diagnosis can be received, by first, calculating specific physical parameters from the signal, and subsequently, analyzing them with a machine learning algorithm containing neuronal networks. In this multi-center analysis, the primary evaluated outcome was the accuracy of the CSG Diagnosis System, validated by a five-fold nested cross-validation in comparison to angiographic findings as the gold standard. Individuals with 1, 2, or 3- vessel disease were defined as being affected. RESULTS:Of the 595 patients, 62·0% (n = 369) had 1, 2 or 3- vessel disease identified by coronary angiography. CSG identified a CAD at rest with a sensitivity of 90·2 ± 4·2% for female patients (male: 97·2 ± 3·1%), specificity of 74·4 ± 9·8% (male: 76·1 ± 8·5%), and overall accuracy of 82·5 ± 6·4% (male: 90·7 ± 3·3%). CONCLUSION:These findings demonstrate that supervised artificial intelligence-enabled vectorcardiography can overcome limitations of conventional non-invasive diagnostic modalities for the detection of coronary ischemia at rest and is capable as a highly valid screening tool.
journal_name
J Electrocardioljournal_title
Journal of electrocardiologyauthors
Braun T,Spiliopoulos S,Veltman C,Hergesell V,Passow A,Tenderich G,Borggrefe M,Koerner MMdoi
10.1016/j.jelectrocard.2019.12.018subject
Has Abstractpub_date
2020-01-01 00:00:00pages
100-105eissn
0022-0736issn
1532-8430pii
S0022-0736(19)30695-8journal_volume
59pub_type
杂志文章abstract:AIM:The aim of this study was to investigate whether interventricular asynchrony (IVA) can be measured by electrocardiography. METHODS:Sixty-two patients (New York Heart Association heart failure functional class III: age, mean +/- SD: 64 +/- 9 years; ejection fraction, mean +/- SD: 24% +/- 8%; dilative cardiomyopathy...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2009.12.006
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:The ventricular repolarization (VR) response to short-lasting coronary occlusion has been characterized by 3-dimensional vectorcardiography during angioplasty in humans; the T-vector loop becomes distorted (increased T(avplan)) and more circular (decreased T(eigenvalue)), but these changes have not been rela...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2008.11.001
更新日期:2009-05-01 00:00:00
abstract::A graph consisting of small squares of equal size preprinted on a transparent plastic chart can be used for a quick and accurate calculation of the VCG loop area in each quadrant of the three conventional planes. ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(79)80013-8
更新日期:1979-10-01 00:00:00
abstract::In treating atrial fibrillation (AF) the goal of ventricular rate reduction is still not determined. An animal model of AF was developed in which the relationship between ventricular rate and the parameters of cardiac function in AF can be studied. To simulate AF, complete heart block was chemically produced on open-c...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(05)80100-1
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The appearance of a discrete upward deflection of the ST segment, termed the ST hump sign during exercise testing has been associated with resting hypertension and exaggerated blood pressure response to exercise. OBJECTIVE:We investigated the correlation between the presence of hump sign during exercise tes...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2009.09.001
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Most patients presenting with suspected acute coronary syndrome (ACS) are admitted to telemetry units. While telemetry is an appropriate level of care, acute complications requiring a higher level of care in the intensive care unit (ICU) occur. PURPOSE:Among patients admitted to telemetry for suspected ACS,...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2016.08.010
更新日期:2016-01-01 00:00:00
abstract::Inferior paraseptal accessory pathways (APs) have a wide distribution and prediction of AP location before radiofrequency ablation is very important in such pathways. We aimed to estimate successful ablation site based on electrocardiogram in 137 patients (mean age: 25.8±9.0; 126 males) with single manifest inferior p...
journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章
doi:10.1016/j.jelectrocard.2015.12.017
更新日期:2016-03-01 00:00:00
abstract::Body surface potential mapping assessed mean cardiac electrical activation times displayed by isochronal maps in the right ventricle (RV; right ventricle mean activation time [mRV]), anterior septal area (anterior septal area mean activation time [mAS]), and left ventricle (left ventricle mean activation time [mLV]) o...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2005.07.004
更新日期:2006-01-01 00:00:00
abstract::We hypothesized that if the right atrial circuit during isthmus dependent atrial flutter provides the dominant contribution to the surface electrocardiogram (ECG), the three-dimensional vector loop of the flutter waves would primarily be in a plane approximately parallel to the tricuspid ring. Twenty vectorcardiograms...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2003.09.055
更新日期:2003-01-01 00:00:00
abstract::Methods currently exist for the precise measurement of local three-dimensional myocardial motion noninvasivly with magnetic resonace imaging tagging. From these motion estimates, strain images representing the local deformation of the myocardium can be formed to show local myocardial contraction. These images clearly ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1054/jelc.2002.37156
更新日期:2002-01-01 00:00:00
abstract::Cardiac gap junctions are responsible for normal conduction properties of the ventricles. Alteration in gap junction distribution (remodeling) in ischemic heart disease is likely to be an important cause of life threatening ventricular arrhythmias. ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1054/jelc.2001.28834
更新日期:2001-01-01 00:00:00
abstract::New developments in instrumentation, in clinical application, as well as in data analysis and visualization have provided new momentum to magnetocardiography (MCG). On one hand robust, easy to use and budget-priced MCG-systems entered the market and are applied to a multi-centred clinical study. On the other hand high...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2004.08.035
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:This study aims to develop a noninvasive atrial remodeling index (RI) to separate patients presenting paroxysmal atrial fibrillation (ParAF) from those with sustained persistent atrial fibrillation (PerAF), that is, AF episodes interrupted 7 days or more after the onset. METHODS:Signal-averaged P-wave duration...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2011.08.005
更新日期:2012-03-01 00:00:00
abstract::This study described the linear relationship of the myocardial infarct size, measured postmortem, to the integral of the sequential vector spatial magnitudes analyzed at 400 samples per second during the initial period of abnormal depolarization (IAD) in 25 patients with myocardial infarction (MI) and ten controls. Th...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(82)81002-9
更新日期:1982-10-01 00:00:00
abstract::A prolonged QT interval is an important prognostic indicator for cardiac arrhythmias and sudden death. The conventional QT interval measurement, however, includes in its measure the cardiac depolarization (QRS) as well as the cardiac repolarization (JT) intervals. To evaluate the relative contribution of the depolariz...
journal_title:Journal of electrocardiology
pub_type: 临床试验,杂志文章
doi:10.1016/0022-0736(90)90150-z
更新日期:1990-01-01 00:00:00
abstract::Precordial electrocardiographic leads V1, V2, V5, V6, and limb leads I and II were recorded simultaneously utilizing radio transparent electrodes and wire leads during coronary angiography in 35 patients with obstructive coronary disease and in 17 subjects with normal coronary angiograms. The pattern of electrocardiog...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(76)80047-7
更新日期:1976-01-01 00:00:00
abstract::To assess the effect of pacing drive cycle length on induction of sustained monomorphic ventricular tachycardia, 40 patients were prospectively studied in the drug-free state. Ventricular extrastimuli were sequentially delivered at the same coupling interval at each of three drive cycle lengths (600, 500, and 400 ms) ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(92)90127-l
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Ventricular arrhythmias and sudden cardiac deaths are the most common cause of mortality in patients with end-stage renal disease (ESRD). Index of cardiac-electrophysiological balance (iCEB) (QT/QRS) may predict malignant ventricular arrhythmias. In this study, we investigated whether iCEB value is increased...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.03.011
更新日期:2019-01-01 00:00:00
abstract::Effects of pirmenol hydrochloride and lidocaine hydrochloride on intraventricular conduction were examined in the infarcted heart of anesthetized dogs. The effects of the drugs on the excitation induced by ventricular stimulations were determined with coupling intervals between 150 and 1,000 ms. Effects of the drugs o...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/0022-0736(91)90020-m
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND AND AIM:Acute ST-elevation myocardial infarction (STEMI) is associated with fatal and non-fatal ventricular arrhythmic events (VAE). Although primary percutaneous intervention (PCI) is first-line treatment in STEMI, fibrinolytic therapy (FT) is still widely used in many countries. Tp-Te interval; Tp-Te/QT ra...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.07.004
更新日期:2019-01-01 00:00:00
abstract::The purpose of this experiment is to study the possibility of intra-QRS high-frequency electrocardiographic (HFECG) changes for the evaluation of and recovery from myocardial ischemia in both the time-domain and spectral-turbulence analyses on the signal-averaged ECG using the Holter ECG monitoring (Holter SAECG) syst...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(95)80064-6
更新日期:1995-01-01 00:00:00
abstract::The importance of plasma electrolytes and pH levels in determining heart rate is not yet well grounded. Hemodynamic and biochemical data were collected during 8 purely diffusive hemodialysis, which allowed changes in extracellular fluid to be achieved without eliciting notable changes in the autonomic control of heart...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1054/jelc.2002.31819
更新日期:2002-04-01 00:00:00
abstract::Two cases of transient hemiblock occurring during the course of acute myocardial infarction are reported. The transient manifestation permits the accurate evaluation of the diagnostic features of the hemiblocks as modified by acute infarction. One case reflects the development of left bundle branch block due to bilate...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(78)80109-5
更新日期:1978-04-01 00:00:00
abstract::The case of a patient with complete atrioventricular block with capability of rapid ventriculoatrial conduction with unusual behavior is presented. Potential mechanisms are discussed. ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2012.03.005
更新日期:2012-07-01 00:00:00
abstract:BACKGROUND:We aimed to evaluate possible association between QRS duration (QRSD), R wave peak time (RWPT), and coronary artery disease severity identified using the SYNTAX score (SS) in patients with unstable angina pectoris (USAP) or non-ST segment elevation myocardial infarction (NSTEMI). METHOD:A total of 176 USAP/...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2017.09.009
更新日期:2018-01-01 00:00:00
abstract::The long QT syndrome is an inherited arrhythmogenic disease characterized by prolongation of QT interval, syncope, and sudden cardiac death because of ventricular tachycardia, mainly in the form of Torsades de Pointes. We present an unusual case of prolonged QT interval and cardiac arrest caused by Torsades de Pointes...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2010.12.001
更新日期:2011-05-01 00:00:00
abstract::A 53-year-old patient had a complex ventricular arrhythmia, which most likely was an intermittent pure (nonmodulated) parasystole, due to protection limited to the first part of the cycle coexisting with exit block. However, other interpretations of the observations were possible. Foremost among these was modulated pa...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(97)80046-5
更新日期:1997-10-01 00:00:00
abstract::From a population of 304 patients who were operated on for atrial septal defects, 25 patients with primum defects and 78 patients with secundum defects were studied with regard to the ability of various quantitative axial lead vectorcardiographic (VCG) data to predict the anatomical type of defect. The patients includ...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/s0022-0736(75)80023-9
更新日期:1975-01-01 00:00:00
abstract:INTRODUCTION:The mechanisms of torsade de pointes tachycardia (TdP) are incompletely understood. We aimed to investigate the mechanisms underlying TdP tachycardia in patients with spontaneous high-degree atrioventricular block (AVB). METHODS AND RESULTS:This retrospective study reviewed old TdP recordings after ventri...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2019.05.007
更新日期:2019-01-01 00:00:00
abstract:INTRODUCTION:Structural right atrial abnormalities have been described in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). However, little is known about electrocardiographic signs of atrial involvement in ARVC because no systematic studies have been conducted. METHODS:P-wave-triggered signal-aver...
journal_title:Journal of electrocardiology
pub_type: 杂志文章
doi:10.1016/j.jelectrocard.2010.08.008
更新日期:2011-03-01 00:00:00